Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder / William E. DECOTEAU in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2414-2429 Titre : Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder Type de document : texte imprimé Auteurs : William E. DECOTEAU, Auteur ; Adam E. FOX, Auteur Article en page(s) : p.2414-2429 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Delay discounting  Rats  Time perception  Timing  Valproic Acid Index. décimale : PER Périodiques Résumé : Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-021-05129-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder [texte imprimé] / William E. DECOTEAU, Auteur ; Adam E. FOX, Auteur . - p.2414-2429. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2414-2429 Mots-clés : Autism spectrum disorder (ASD)  Delay discounting  Rats  Time perception  Timing  Valproic Acid Index. décimale : PER Périodiques Résumé : Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-021-05129-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

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