Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples / Lisa D. WIGGINS in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.539-550 Titre : Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples Type de document : Texte imprimé et/ou numérique Auteurs : Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Eric RUBENSTEIN, Auteur ; Laura A. SCHIEVE, Auteur ; Julie L. DANIELS, Auteur ; Karen PAZOL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Brian BARGER, Auteur ; Eric MOODY, Auteur ; Steven ROSENBERG, Auteur ; Chyrise BRADLEY, Auteur ; Melanie HSU, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Deborah CHRISTENSEN, Auteur ; Tessa CRUME, Auteur ; Juhi PANDEY, Auteur ; Susan E. LEVY, Auteur Article en page(s) : p.539-550 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2?5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite case?control study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research. En ligne : https://doi.org/10.1002/aur.2663 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples [Texte imprimé et/ou numérique] / Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Eric RUBENSTEIN, Auteur ; Laura A. SCHIEVE, Auteur ; Julie L. DANIELS, Auteur ; Karen PAZOL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Brian BARGER, Auteur ; Eric MOODY, Auteur ; Steven ROSENBERG, Auteur ; Chyrise BRADLEY, Auteur ; Melanie HSU, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Deborah CHRISTENSEN, Auteur ; Tessa CRUME, Auteur ; Juhi PANDEY, Auteur ; Susan E. LEVY, Auteur . - p.539-550. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.539-550 Index. décimale : PER Périodiques Résumé : Abstract The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2?5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite case?control study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research. En ligne : https://doi.org/10.1002/aur.2663 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Racial and ethnic disparities in the co-occurrence of intellectual disability and autism: Impact of incorporating measures of adaptive functioning / Sarah M. FURNIER in Autism Research, 17-3 (March 2024)  

Public ISBD [article]  inAutism Research > 17-3 (March 2024) . - p.650-667 Titre : Racial and ethnic disparities in the co-occurrence of intellectual disability and autism: Impact of incorporating measures of adaptive functioning Type de document : Texte imprimé et/ou numérique Auteurs : Sarah M. FURNIER, Auteur ; Ronald GANGNON, Auteur ; Julie L. DANIELS, Auteur ; Susan ELLIS WEISMER, Auteur ; Cy NADLER, Auteur ; Karen PAZOL, Auteur ; Nuri M. REYES, Auteur ; Steven ROSENBERG, Auteur ; Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Maureen S. DURKIN, Auteur Article en page(s) : p.650-667 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Intellectual disability (ID) commonly co-occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population-based estimates of the frequency of co-occurring ID in children with autism-including studies of racial and ethnic disparities in co-occurring autism and ID-base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co-occurring ID in a well-characterized sample of 2- to 5-year-old children with autism. Participants included 3264 children with research or community diagnoses of autism enrolled in the population-based Study to Explore Early Development (SEED) phases 1-3. Based only on Mullen Scales of Early Learning (MSEL) composite cognitive scores, 62.9% (95% confidence interval [CI]: 61.1, 64.7%) of children with autism were estimated to have co-occurring ID. After incorporating Vineland Adaptive Behavior Scales, Second Edition (VABS-II) composite or domains criteria, co-occurring ID estimates were reduced to 38.0% (95% CI: 36.2, 39.8%) and 45.0% (95% CI: 43.1, 46.9%), respectively. The increased odds of meeting ID criteria observed for non-Hispanic (NH) Black and Hispanic children relative to NH White children when only MSEL criteria were used were substantially reduced, though not eliminated, after incorporating VABS-II criteria and adjusting for selected socioeconomic variables. This study provides evidence for the importance of considering adaptive behavior as well as socioeconomic disadvantage when describing racial and ethnic disparities in co-occurring ID in epidemiologic studies of autism. En ligne : https://doi.org/10.1002/aur.3107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525 [article] Racial and ethnic disparities in the co-occurrence of intellectual disability and autism: Impact of incorporating measures of adaptive functioning [Texte imprimé et/ou numérique] / Sarah M. FURNIER, Auteur ; Ronald GANGNON, Auteur ; Julie L. DANIELS, Auteur ; Susan ELLIS WEISMER, Auteur ; Cy NADLER, Auteur ; Karen PAZOL, Auteur ; Nuri M. REYES, Auteur ; Steven ROSENBERG, Auteur ; Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Maureen S. DURKIN, Auteur . - p.650-667. Langues : Anglais (eng) in Autism Research > 17-3 (March 2024) . - p.650-667 Index. décimale : PER Périodiques Résumé : Abstract Intellectual disability (ID) commonly co-occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population-based estimates of the frequency of co-occurring ID in children with autism-including studies of racial and ethnic disparities in co-occurring autism and ID-base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co-occurring ID in a well-characterized sample of 2- to 5-year-old children with autism. Participants included 3264 children with research or community diagnoses of autism enrolled in the population-based Study to Explore Early Development (SEED) phases 1-3. Based only on Mullen Scales of Early Learning (MSEL) composite cognitive scores, 62.9% (95% confidence interval [CI]: 61.1, 64.7%) of children with autism were estimated to have co-occurring ID. After incorporating Vineland Adaptive Behavior Scales, Second Edition (VABS-II) composite or domains criteria, co-occurring ID estimates were reduced to 38.0% (95% CI: 36.2, 39.8%) and 45.0% (95% CI: 43.1, 46.9%), respectively. The increased odds of meeting ID criteria observed for non-Hispanic (NH) Black and Hispanic children relative to NH White children when only MSEL criteria were used were substantially reduced, though not eliminated, after incorporating VABS-II criteria and adjusting for selected socioeconomic variables. This study provides evidence for the importance of considering adaptive behavior as well as socioeconomic disadvantage when describing racial and ethnic disparities in co-occurring ID in epidemiologic studies of autism. En ligne : https://doi.org/10.1002/aur.3107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525

Risk factors and clinical correlates of sensory dysfunction in preschool children with and without autism spectrum disorder / Katie OVERWYK ; Julie DANIELS ; Brian BARGER ; Hayley CRAIN ; Rebecca GRZADZINSKI ; Eric MOODY ; Ann REYNOLDS ; Nuri REYES ; Cordelia ROSENBERG ; Steven ROSENBERG ; Karen PAZOL in Autism Research, 17-1 (January 2024)  

Public ISBD [article]  inAutism Research > 17-1 (January 2024) . - p.162-171 Titre : Risk factors and clinical correlates of sensory dysfunction in preschool children with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katie OVERWYK, Auteur ; Julie DANIELS, Auteur ; Brian BARGER, Auteur ; Hayley CRAIN, Auteur ; Rebecca GRZADZINSKI, Auteur ; Eric MOODY, Auteur ; Ann REYNOLDS, Auteur ; Nuri REYES, Auteur ; Cordelia ROSENBERG, Auteur ; Steven ROSENBERG, Auteur ; Karen PAZOL, Auteur Article en page(s) : p.162-171 Index. décimale : PER Périodiques Résumé : Abstract Sensory dysfunction is a common feature of autism spectrum disorder (ASD). The objectives of this analysis were to examine risk factors and clinical correlates of sensory dysfunction in preschool children with and without ASD. Children aged 2?5?years were enrolled in a multi-site case?control study. Data were collected in eight areas across the United States in three phases. Caregivers completed an interview with questions on assisted delivery, maternal alcohol use, maternal anxiety during pregnancy, pregnancy weight gain, neonatal jaundice, preterm birth, and child sensory diagnosis given by a healthcare provider. Caregivers also completed an interview and questionnaires on sensory symptoms and clinical correlates of sensory dysfunction in their child. There were 2059 children classified as ASD, 3139 as other developmental delay or disability (DD), and 3249 as population comparison (POP). Caregivers reported significantly more sensory diagnoses and sensory symptoms in children classified as ASD than DD or POP (23.7%, 8.6%, and 0.8%, respectively, for a sensory diagnosis and up to 78.7% [ASD] vs. 49.6% [DD] for sensory symptoms). Maternal anxiety during pregnancy and neonatal jaundice were significantly associated with a sensory diagnosis and certain sensory symptoms in children with ASD and DD. Children's anxiety, attention deficits/hyperactivity, and sleep problems were significantly albeit subtly correlated with both a sensory diagnosis and sensory symptoms in children with ASD and DD. These findings support sensory dysfunction as a distinguishing symptom of ASD in preschool children and identify risk factors and clinical correlates to inform screening and treatment efforts in those with atypical development. En ligne : https://doi.org/10.1002/aur.3074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Risk factors and clinical correlates of sensory dysfunction in preschool children with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Katie OVERWYK, Auteur ; Julie DANIELS, Auteur ; Brian BARGER, Auteur ; Hayley CRAIN, Auteur ; Rebecca GRZADZINSKI, Auteur ; Eric MOODY, Auteur ; Ann REYNOLDS, Auteur ; Nuri REYES, Auteur ; Cordelia ROSENBERG, Auteur ; Steven ROSENBERG, Auteur ; Karen PAZOL, Auteur . - p.162-171. in Autism Research > 17-1 (January 2024) . - p.162-171 Index. décimale : PER Périodiques Résumé : Abstract Sensory dysfunction is a common feature of autism spectrum disorder (ASD). The objectives of this analysis were to examine risk factors and clinical correlates of sensory dysfunction in preschool children with and without ASD. Children aged 2?5?years were enrolled in a multi-site case?control study. Data were collected in eight areas across the United States in three phases. Caregivers completed an interview with questions on assisted delivery, maternal alcohol use, maternal anxiety during pregnancy, pregnancy weight gain, neonatal jaundice, preterm birth, and child sensory diagnosis given by a healthcare provider. Caregivers also completed an interview and questionnaires on sensory symptoms and clinical correlates of sensory dysfunction in their child. There were 2059 children classified as ASD, 3139 as other developmental delay or disability (DD), and 3249 as population comparison (POP). Caregivers reported significantly more sensory diagnoses and sensory symptoms in children classified as ASD than DD or POP (23.7%, 8.6%, and 0.8%, respectively, for a sensory diagnosis and up to 78.7% [ASD] vs. 49.6% [DD] for sensory symptoms). Maternal anxiety during pregnancy and neonatal jaundice were significantly associated with a sensory diagnosis and certain sensory symptoms in children with ASD and DD. Children's anxiety, attention deficits/hyperactivity, and sleep problems were significantly albeit subtly correlated with both a sensory diagnosis and sensory symptoms in children with ASD and DD. These findings support sensory dysfunction as a distinguishing symptom of ASD in preschool children and identify risk factors and clinical correlates to inform screening and treatment efforts in those with atypical development. En ligne : https://doi.org/10.1002/aur.3074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

---

1 (1 - 3 / 3)