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Auteur Susan ELLIS WEISMER |
Documents disponibles écrits par cet auteur (22)
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Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children / Olivia SURGENT in Molecular Autism, 13 (2022)
[article]
Titre : Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Humans Child White Matter Brain Quality of Life Autistic Disorder Brain Stem Autism Brainstem Dti Sensory features Voxel-based analysis White matter TherVoyant). While both companies are involved in developing MRI-based surgery techniques, neither are associated with any current areas of his research, including the present publication. All other authors report no biomedical financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11Â years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 48 p.[article] Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children [Texte imprimé et/ou numérique] / Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur . - 48 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 48 p.
Mots-clés : Humans Child White Matter Brain Quality of Life Autistic Disorder Brain Stem Autism Brainstem Dti Sensory features Voxel-based analysis White matter TherVoyant). While both companies are involved in developing MRI-based surgery techniques, neither are associated with any current areas of his research, including the present publication. All other authors report no biomedical financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11Â years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder / Sara T. KOVER in Journal of Autism and Developmental Disorders, 46-7 (July 2016)
[article]
Titre : Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sara T. KOVER, Auteur ; Sarah R. EDMUNDS, Auteur ; Susan ELLIS WEISMER, Auteur Article en page(s) : p.2501-2507 Langues : Anglais (eng) Mots-clés : First words Trajectories Language development Index. décimale : PER Périodiques Résumé : Recognizing early risk markers in young children with autism spectrum disorder (ASD) is critical for timely diagnosis and intervention. The purpose of this study was to extend previous findings regarding language milestones to a longitudinal design, in which ages of expressive language milestones (i.e., first words, first phrases) could serve as predictors of developmental trajectories in a heterogeneous sample of young children with ASD (N = 98; age at first assessment: M = 32 months, SD = 5). Age of first words predicted trajectories of expressive language and adaptive skills; number of words predicted each outcome examined. Because these aspects of early language show promise as potential indicators of later functional outcomes, future research on developmental processes as they relate to individual differences will be particularly informative. En ligne : http://dx.doi.org/10.1007/s10803-016-2756-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2501-2507[article] Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sara T. KOVER, Auteur ; Sarah R. EDMUNDS, Auteur ; Susan ELLIS WEISMER, Auteur . - p.2501-2507.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2501-2507
Mots-clés : First words Trajectories Language development Index. décimale : PER Périodiques Résumé : Recognizing early risk markers in young children with autism spectrum disorder (ASD) is critical for timely diagnosis and intervention. The purpose of this study was to extend previous findings regarding language milestones to a longitudinal design, in which ages of expressive language milestones (i.e., first words, first phrases) could serve as predictors of developmental trajectories in a heterogeneous sample of young children with ASD (N = 98; age at first assessment: M = 32 months, SD = 5). Age of first words predicted trajectories of expressive language and adaptive skills; number of words predicted each outcome examined. Because these aspects of early language show promise as potential indicators of later functional outcomes, future research on developmental processes as they relate to individual differences will be particularly informative. En ligne : http://dx.doi.org/10.1007/s10803-016-2756-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Brief Report: Early Lexical Comprehension in Young Children with ASD: Comparing Eye-Gaze Methodology and Parent Report / Courtney E. VENKER in Journal of Autism and Developmental Disorders, 46-6 (June 2016)
[article]
Titre : Brief Report: Early Lexical Comprehension in Young Children with ASD: Comparing Eye-Gaze Methodology and Parent Report Type de document : Texte imprimé et/ou numérique Auteurs : Courtney E. VENKER, Auteur ; Eileen HAEBIG, Auteur ; Jan EDWARDS, Auteur ; Jenny SAFFRAN, Auteur ; Susan ELLIS WEISMER, Auteur Article en page(s) : p.2260-2266 Langues : Anglais (eng) Mots-clés : Assessment Receptive vocabulary Lexical comprehension Parent report Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Lexical comprehension is commonly measured by parent report, but it may be difficult for parents of children with ASD to accurately judge their child’s comprehension. We compared parent report to an eye-gaze measure of lexical comprehension in which participants observed pairs of images on a screen, along with accompanying speech that named one of the two images. Twenty-two toddlers with ASD participated. Trials were included if the target word was reported as unknown. Children spent significantly more time looking at the target after it was named than before (d = 0.66). These results provide evidence that eye-gaze measures can reveal emerging lexical knowledge in young children with ASD that may otherwise be overlooked. En ligne : http://dx.doi.org/10.1007/s10803-016-2747-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289
in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2260-2266[article] Brief Report: Early Lexical Comprehension in Young Children with ASD: Comparing Eye-Gaze Methodology and Parent Report [Texte imprimé et/ou numérique] / Courtney E. VENKER, Auteur ; Eileen HAEBIG, Auteur ; Jan EDWARDS, Auteur ; Jenny SAFFRAN, Auteur ; Susan ELLIS WEISMER, Auteur . - p.2260-2266.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2260-2266
Mots-clés : Assessment Receptive vocabulary Lexical comprehension Parent report Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Lexical comprehension is commonly measured by parent report, but it may be difficult for parents of children with ASD to accurately judge their child’s comprehension. We compared parent report to an eye-gaze measure of lexical comprehension in which participants observed pairs of images on a screen, along with accompanying speech that named one of the two images. Twenty-two toddlers with ASD participated. Trials were included if the target word was reported as unknown. Children spent significantly more time looking at the target after it was named than before (d = 0.66). These results provide evidence that eye-gaze measures can reveal emerging lexical knowledge in young children with ASD that may otherwise be overlooked. En ligne : http://dx.doi.org/10.1007/s10803-016-2747-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 Brief Report: Fast Mapping Predicts Differences in Concurrent and Later Language Abilities Among Children with ASD / Courtney E. VENKER in Journal of Autism and Developmental Disorders, 46-3 (March 2016)
[article]
Titre : Brief Report: Fast Mapping Predicts Differences in Concurrent and Later Language Abilities Among Children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Courtney E. VENKER, Auteur ; Sara T. KOVER, Auteur ; Susan ELLIS WEISMER, Auteur Article en page(s) : p.1118-1123 Langues : Anglais (eng) Mots-clés : Fast mapping Word learning Language Cognition Autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study investigated whether the ability to learn word-object associations following minimal exposure (i.e., fast mapping) was associated with concurrent and later language abilities in children with ASD. Children who were poor learners at age 3½ had significantly lower receptive language abilities than children who successfully learned the new words, both concurrently (n = 59) and 2 years later (n = 53), lending ecological validity to experimental fast-mapping tasks. Fast mapping comprehension at age 3½ was associated with better language outcomes regardless of whether children had produced the new words. These findings highlight the importance of investigating processes of language learning in children with ASD. Understanding these processes will enable the development of maximally effective strategies for supporting word learning. En ligne : http://dx.doi.org/10.1007/s10803-015-2644-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1118-1123[article] Brief Report: Fast Mapping Predicts Differences in Concurrent and Later Language Abilities Among Children with ASD [Texte imprimé et/ou numérique] / Courtney E. VENKER, Auteur ; Sara T. KOVER, Auteur ; Susan ELLIS WEISMER, Auteur . - p.1118-1123.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1118-1123
Mots-clés : Fast mapping Word learning Language Cognition Autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study investigated whether the ability to learn word-object associations following minimal exposure (i.e., fast mapping) was associated with concurrent and later language abilities in children with ASD. Children who were poor learners at age 3½ had significantly lower receptive language abilities than children who successfully learned the new words, both concurrently (n = 59) and 2 years later (n = 53), lending ecological validity to experimental fast-mapping tasks. Fast mapping comprehension at age 3½ was associated with better language outcomes regardless of whether children had produced the new words. These findings highlight the importance of investigating processes of language learning in children with ASD. Understanding these processes will enable the development of maximally effective strategies for supporting word learning. En ligne : http://dx.doi.org/10.1007/s10803-015-2644-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Brief Report: Parent Verbal Responsiveness and Language Development in Toddlers on the Autism Spectrum / Eileen HAEBIG in Journal of Autism and Developmental Disorders, 43-9 (September 2013)
[article]
Titre : Brief Report: Parent Verbal Responsiveness and Language Development in Toddlers on the Autism Spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Eileen HAEBIG, Auteur ; Andrea MCDUFFIE, Auteur ; Susan ELLIS WEISMER, Auteur Article en page(s) : p.2218-2227 Langues : Anglais (eng) Mots-clés : Autism Parent responsiveness Parent–child interactions Index. décimale : PER Périodiques Résumé : This study examined the longitudinal associations between parent verbal responsiveness and language 3 years later in 34 toddlers with a diagnosis of an autism spectrum disorder. Parent–child play samples were coded for child engagement and communication acts and for parent verbal responsiveness. Measures of responsive verbal behaviors were used to predict language gain scores 3 years later. Parent directives for language that followed into the child’s focus of attention were predictive of child receptive language gains. Parent comments that followed into the child’s focus of attention yielded differential effects depending on initial levels of child language. Children who were minimally verbal at age 2½ benefited from parent comments that followed into the their focus of attention, whereas children who were verbally fluent did not demonstrate such a benefit. En ligne : http://dx.doi.org/10.1007/s10803-013-1763-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2218-2227[article] Brief Report: Parent Verbal Responsiveness and Language Development in Toddlers on the Autism Spectrum [Texte imprimé et/ou numérique] / Eileen HAEBIG, Auteur ; Andrea MCDUFFIE, Auteur ; Susan ELLIS WEISMER, Auteur . - p.2218-2227.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2218-2227
Mots-clés : Autism Parent responsiveness Parent–child interactions Index. décimale : PER Périodiques Résumé : This study examined the longitudinal associations between parent verbal responsiveness and language 3 years later in 34 toddlers with a diagnosis of an autism spectrum disorder. Parent–child play samples were coded for child engagement and communication acts and for parent verbal responsiveness. Measures of responsive verbal behaviors were used to predict language gain scores 3 years later. Parent directives for language that followed into the child’s focus of attention were predictive of child receptive language gains. Parent comments that followed into the child’s focus of attention yielded differential effects depending on initial levels of child language. Children who were minimally verbal at age 2½ benefited from parent comments that followed into the their focus of attention, whereas children who were verbally fluent did not demonstrate such a benefit. En ligne : http://dx.doi.org/10.1007/s10803-013-1763-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 Characterization and Prediction of Early Reading Abilities in Children on the Autism Spectrum / Meghan M. DAVIDSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
PermalinkChildren with ASD and Communication Regression: Examining Pre-Loss Skills and Later Language Outcomes Through the Preschool Years / Kathryn E. PRESCOTT in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
PermalinkComparing Automatic Eye Tracking and Manual Gaze Coding Methods in Young Children with Autism Spectrum Disorder / Courtney E. VENKER in Autism Research, 13-2 (February 2020)
PermalinkA Discrepancy in Comprehension and Production in Early Language Development in ASD: Is it Clinically Relevant? / Meghan M. DAVIDSON in Journal of Autism and Developmental Disorders, 47-7 (July 2017)
PermalinkIncreasing verbal responsiveness in parents of children with autism:a pilot study / Courtney E. VENKER in Autism, 16-6 (November 2012)
PermalinkLexical Processing in School-Age Children with Autism Spectrum Disorder and Children with Specific Language Impairment: The Role of Semantics / Eileen HAEBIG in Journal of Autism and Developmental Disorders, 45-12 (December 2015)
PermalinkLexical Processing in Toddlers with ASD: Does Weak Central Coherence Play a Role? / Susan ELLIS WEISMER in Journal of Autism and Developmental Disorders, 46-12 (December 2016)
PermalinkNaturalistic parent–child reading frequency and language development in toddlers with and without autism / Janine MATHEE-SCOTT in Autism & Developmental Language Impairments, 7 (January-December 2022)
PermalinkPredictive language processing in young autistic children / Kathryn E. PRESCOTT in Autism Research, 15-5 (May 2022)
PermalinkA preliminary investigation of parent-reported fiction versus non-fiction book preferences of school-age children with autism spectrum disorder / Meghan M. DAVIDSON in Autism & Developmental Language Impairments, 3 (January-December 2018)
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