Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder / Elizabeth S. HELLER MURRAY in Research in Autism Spectrum Disorders, 94 (June 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 94 (June 2022) . - 101955 Titre : Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth S. HELLER MURRAY, Auteur ; Jennifer SEGAWA, Auteur ; F. Isik KARAHANOGLU, Auteur ; Catherine TOCCI, Auteur ; Jason A. TOURVILLE, Auteur ; Alfonso NIETO-CASTANON, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Dara S. MANOACH, Auteur ; Frank H. GUENTHER, Auteur Article en page(s) : 101955 Langues : Anglais (eng) Mots-clés : Speech  Functional magnetic resonance imaging  Communication  Variability Index. décimale : PER Périodiques Résumé : Background Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions These findings highlight the importance of understanding intra-subject neural variability in participants with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder [Texte imprimé et/ou numérique] / Elizabeth S. HELLER MURRAY, Auteur ; Jennifer SEGAWA, Auteur ; F. Isik KARAHANOGLU, Auteur ; Catherine TOCCI, Auteur ; Jason A. TOURVILLE, Auteur ; Alfonso NIETO-CASTANON, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Dara S. MANOACH, Auteur ; Frank H. GUENTHER, Auteur . - 101955. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101955 Mots-clés : Speech  Functional magnetic resonance imaging  Communication  Variability Index. décimale : PER Périodiques Résumé : Background Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions These findings highlight the importance of understanding intra-subject neural variability in participants with ASD. En ligne : https://doi.org/10.1016/j.rasd.2022.101955 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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