Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome / Joel STODDARD in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.76-85 Titre : Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Joel STODDARD, Auteur ; Laurel BECKETT, Auteur ; Tony J. SIMON, Auteur Article en page(s) : p.76-85 Langues : Anglais (eng) Mots-clés : Attention networks task  Chromosome 22q11.2 deletion syndrome  Cognitive control Index. décimale : PER Périodiques Résumé : Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue x flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s11689-010-9070-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome [texte imprimé] / Joel STODDARD, Auteur ; Laurel BECKETT, Auteur ; Tony J. SIMON, Auteur . - p.76-85. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.76-85 Mots-clés : Attention networks task  Chromosome 22q11.2 deletion syndrome  Cognitive control Index. décimale : PER Périodiques Résumé : Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue x flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s11689-010-9070-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

Brief Report: Methods for Acquiring Structural MRI Data in Very Young Children with Autism Without the Use of Sedation / Christine W. NORDAHL in Journal of Autism and Developmental Disorders, 38-8 (September 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-8 (September 2008) . - p.1581-1590 Titre : Brief Report: Methods for Acquiring Structural MRI Data in Very Young Children with Autism Without the Use of Sedation Type de document : texte imprimé Auteurs : Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur ; Marjorie SOLOMON, Auteur ; Tony J. SIMON, Auteur ; Cynthia ZIERHUT, Auteur ; Sally J. ROGERS, Auteur Année de publication : 2008 Article en page(s) : p.1581-1590 Langues : Anglais (eng) Mots-clés : MRI Autism Natural-sleep Sedation Children Toddlers Index. décimale : PER Périodiques Résumé : We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5–4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child’s normal bedtime. Alternatively, with some older and higher functioning children, the MRI was conducted while the child was awake and watching a video. Both strategies relied heavily on the creation of a child and family friendly MRI environment and the involvement of parents as collaborators in the project. Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases. En ligne : http://dx.doi.org/10.1007/s10803-007-0514-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Brief Report: Methods for Acquiring Structural MRI Data in Very Young Children with Autism Without the Use of Sedation [texte imprimé] / Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur ; Marjorie SOLOMON, Auteur ; Tony J. SIMON, Auteur ; Cynthia ZIERHUT, Auteur ; Sally J. ROGERS, Auteur . - 2008 . - p.1581-1590. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-8 (September 2008) . - p.1581-1590 Mots-clés : MRI Autism Natural-sleep Sedation Children Toddlers Index. décimale : PER Périodiques Résumé : We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5–4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child’s normal bedtime. Alternatively, with some older and higher functioning children, the MRI was conducted while the child was awake and watching a video. Both strategies relied heavily on the creation of a child and family friendly MRI environment and the involvement of parents as collaborators in the project. Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases. En ligne : http://dx.doi.org/10.1007/s10803-007-0514-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Chromosome 22q11.2 deletion syndrome / Kathleen ANGKUSTSIRI

Public ISBD in Autism and Other Neurodevelopmental Disorders / Robin L. HANSEN Titre : Chromosome 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Kathleen ANGKUSTSIRI, Auteur ; Tony J. SIMON, Auteur Année de publication : 2013 Importance : p.83-101 Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 in Autism and Other Neurodevelopmental Disorders / Robin L. HANSEN Chromosome 22q11.2 deletion syndrome [texte imprimé] / Kathleen ANGKUSTSIRI, Auteur ; Tony J. SIMON, Auteur . - 2013 . - p.83-101. Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

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Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes / Andrea I. QUINTERO in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.5 Titre : Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes Type de document : texte imprimé Auteurs : Andrea I. QUINTERO, Auteur ; Elliott A. BEATON, Auteur ; Danielle J. HARVEY, Auteur ; Judith L. ROSS, Auteur ; Tony J. SIMON, Auteur Article en page(s) : p.5 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention. METHODS: Girls with 22q11.2DS, FXS, or TS and typically developing (TD) girls, aged 7 to 15 years, completed an attention network test, a flanker task with alerting and orienting cues. Exploration of reaction times and accuracy allowed us to test for potential commonalities in attentional functioning in alerting, orienting, and executive control. Linear regression models were used to test whether the predictors of group and chronological age were able to predict differences in attention indices. RESULTS: Girls with 22q11.2DS, FXS, or TS demonstrated unimpaired function of the alerting system and impaired function of the executive control system. Diagnosis-specific impairments were found such that girls with FXS made more errors and had a reduced orienting index, while girls with 22q11.2DS showed specific age-related deficits in the executive control system. CONCLUSIONS: These results suggest that the control but not the implementation of attention is selectively impaired in girls with 22q11.2DS, TS or FXS. Additionally, the age effect on executive control in girls with 22q11.2DS implies a possible altered developmental trajectory. En ligne : http://dx.doi.org/10.1186/1866-1955-6-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345 [article] Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes [texte imprimé] / Andrea I. QUINTERO, Auteur ; Elliott A. BEATON, Auteur ; Danielle J. HARVEY, Auteur ; Judith L. ROSS, Auteur ; Tony J. SIMON, Auteur . - p.5. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.5 Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention. METHODS: Girls with 22q11.2DS, FXS, or TS and typically developing (TD) girls, aged 7 to 15 years, completed an attention network test, a flanker task with alerting and orienting cues. Exploration of reaction times and accuracy allowed us to test for potential commonalities in attentional functioning in alerting, orienting, and executive control. Linear regression models were used to test whether the predictors of group and chronological age were able to predict differences in attention indices. RESULTS: Girls with 22q11.2DS, FXS, or TS demonstrated unimpaired function of the alerting system and impaired function of the executive control system. Diagnosis-specific impairments were found such that girls with FXS made more errors and had a reduced orienting index, while girls with 22q11.2DS showed specific age-related deficits in the executive control system. CONCLUSIONS: These results suggest that the control but not the implementation of attention is selectively impaired in girls with 22q11.2DS, TS or FXS. Additionally, the age effect on executive control in girls with 22q11.2DS implies a possible altered developmental trajectory. En ligne : http://dx.doi.org/10.1186/1866-1955-6-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345

A cross-sectional analysis of orienting of visuospatial attention in child and adult carriers of the fragile X premutation / Ling M. WONG in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.45 Titre : A cross-sectional analysis of orienting of visuospatial attention in child and adult carriers of the fragile X premutation Type de document : texte imprimé Auteurs : Ling M. WONG, Auteur ; Naomi J. GOODRICH-HUNSAKER, Auteur ; Yingratana MCLENNAN, Auteur ; Flora TASSONE, Auteur ; Susan M. RIVERA, Auteur ; Tony J. SIMON, Auteur Article en page(s) : p.45 Langues : Anglais (eng) Mots-clés : Cueing  Endogenous  Exogenous  FMR1 gene  Fxtas  Fragile X Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X premutation carriers (fXPCs) have an expansion of 55-200 CGG repeats in the FMR1 gene. Male fXPCs are at risk for developing a neurodegenerative motor disorder (fragile X-associated tremor/ataxia syndrome (FXTAS)) often accompanied by cognitive decline. Several broad domains are implicated as core systems of dysfunction in fXPCs, including perceptual processing of spatial information, orienting of attention to space, and inhibiting attention to irrelevant distractors. We tested whether orienting of spatial attention is impaired in fXPCs. METHODS: Participants were fXPCs or healthy controls (HCs) asymptomatic for FXTAS. In experiment 1, they were male and female children and adults (aged 7-45 years). They oriented attention in response to volitional (endogenous) and reflexive (exogenous) cues. In experiment 2, the participants were men (aged 18-48 years). They oriented attention in an endogenous cueing task that manipulated the amount of information in the cue. RESULTS: In women, fXPCs exhibited slower reaction times than HCs in both the endogenous and exogenous conditions. In men, fXPCs exhibited slower reaction times than HCs in the exogenous condition and in the challenging endogenous cueing task with probabilistic cues. In children, fXPCs did not differ from HCs. CONCLUSIONS: Because adult fXPCs were slower even when controlling for psychomotor speed, results support the interpretation that a core dysfunction in fXPCs is the allocation of spatial attention, while perceptual processing and attention orienting are intact. These findings indicate the importance of considering age and sex when interpreting and generalizing studies of fXPCs. En ligne : http://dx.doi.org/10.1186/1866-1955-6-45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 [article] A cross-sectional analysis of orienting of visuospatial attention in child and adult carriers of the fragile X premutation [texte imprimé] / Ling M. WONG, Auteur ; Naomi J. GOODRICH-HUNSAKER, Auteur ; Yingratana MCLENNAN, Auteur ; Flora TASSONE, Auteur ; Susan M. RIVERA, Auteur ; Tony J. SIMON, Auteur . - p.45. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.45 Mots-clés : Cueing  Endogenous  Exogenous  FMR1 gene  Fxtas  Fragile X Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X premutation carriers (fXPCs) have an expansion of 55-200 CGG repeats in the FMR1 gene. Male fXPCs are at risk for developing a neurodegenerative motor disorder (fragile X-associated tremor/ataxia syndrome (FXTAS)) often accompanied by cognitive decline. Several broad domains are implicated as core systems of dysfunction in fXPCs, including perceptual processing of spatial information, orienting of attention to space, and inhibiting attention to irrelevant distractors. We tested whether orienting of spatial attention is impaired in fXPCs. METHODS: Participants were fXPCs or healthy controls (HCs) asymptomatic for FXTAS. In experiment 1, they were male and female children and adults (aged 7-45 years). They oriented attention in response to volitional (endogenous) and reflexive (exogenous) cues. In experiment 2, the participants were men (aged 18-48 years). They oriented attention in an endogenous cueing task that manipulated the amount of information in the cue. RESULTS: In women, fXPCs exhibited slower reaction times than HCs in both the endogenous and exogenous conditions. In men, fXPCs exhibited slower reaction times than HCs in the exogenous condition and in the challenging endogenous cueing task with probabilistic cues. In children, fXPCs did not differ from HCs. CONCLUSIONS: Because adult fXPCs were slower even when controlling for psychomotor speed, results support the interpretation that a core dysfunction in fXPCs is the allocation of spatial attention, while perceptual processing and attention orienting are intact. These findings indicate the importance of considering age and sex when interpreting and generalizing studies of fXPCs. En ligne : http://dx.doi.org/10.1186/1866-1955-6-45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347

A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11.2 deletion syndrome / Heather M. SHAPIRO in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (June 2015)  

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How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? / Elliott A. BEATON in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)  

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Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome / Margarita H. CABARAL in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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Interrelationship Between Cognitive Control, Anxiety, and Restricted and Repetitive Behaviors in Children with 22q11.2 Deletion Syndrome / Mirko ULJAREVIĆ in Autism Research, 12-12 (December)  

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Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome / Kathryn L. MCCABE in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

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Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)  

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Social Impairments in Chromosome 22q11.2 Deletion Syndrome (22q11.2DS): Autism Spectrum Disorder or a Different Endophenotype? / Kathleen ANGKUSTSIRI in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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The Importance of Understanding Individual Differences of Emotion Regulation Abilities in 22q11.2 Deletion Syndrome / Linda E. CAMPBELL in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

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Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed / Ling M. WONG in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

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