Age Differences in Expression of Generalized and Social Anxiety Among Youth with Autism Spectrum Disorder / R. Enrique VARELA in Journal of Autism and Developmental Disorders, 50-3 (March 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.730-740 Titre : Age Differences in Expression of Generalized and Social Anxiety Among Youth with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. Enrique VARELA, Auteur ; Randolph DUPONT, Auteur ; Jodi L. KAMPS, Auteur ; Carl F. WEEMS, Auteur ; Laura NIDITCH, Auteur ; Elliott A. BEATON, Auteur ; Gabriella PUCCI, Auteur Article en page(s) : p.730-740 Langues : Anglais (eng) Mots-clés : Asd  Anxiety  Development  Generalized anxiety  Social anxiety Index. décimale : PER Périodiques Résumé : This study examined differences in generalized and social anxiety symptoms across two age groups of children with autism spectrum disorder (ASD) while accounting for overall anxiety level, gender, and intellectual functioning. Older children (12-18 years) expressed more overall and social anxiety symptoms than younger children (6-11 years), and social anxiety symptoms were predominant in the older group. Younger children expressed more generalized anxiety symptoms than the older youth, and there was a trend for generalized anxiety symptoms to be more dominant in the younger group. Findings are consistent with theory of differential expression of specific anxiety symptoms across different ages seen with typically developing children, yet social evaluative concerns may be even stronger for adolescents with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04289-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4197 [article] Age Differences in Expression of Generalized and Social Anxiety Among Youth with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / R. Enrique VARELA, Auteur ; Randolph DUPONT, Auteur ; Jodi L. KAMPS, Auteur ; Carl F. WEEMS, Auteur ; Laura NIDITCH, Auteur ; Elliott A. BEATON, Auteur ; Gabriella PUCCI, Auteur . - p.730-740. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.730-740 Mots-clés : Asd  Anxiety  Development  Generalized anxiety  Social anxiety Index. décimale : PER Périodiques Résumé : This study examined differences in generalized and social anxiety symptoms across two age groups of children with autism spectrum disorder (ASD) while accounting for overall anxiety level, gender, and intellectual functioning. Older children (12-18 years) expressed more overall and social anxiety symptoms than younger children (6-11 years), and social anxiety symptoms were predominant in the older group. Younger children expressed more generalized anxiety symptoms than the older youth, and there was a trend for generalized anxiety symptoms to be more dominant in the younger group. Findings are consistent with theory of differential expression of specific anxiety symptoms across different ages seen with typically developing children, yet social evaluative concerns may be even stronger for adolescents with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04289-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4197

Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes / A. I. QUINTERO in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.5 Titre : Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes Type de document : Texte imprimé et/ou numérique Auteurs : A. I. QUINTERO, Auteur ; Elliott A. BEATON, Auteur ; D. J. HARVEY, Auteur ; J. L. ROSS, Auteur ; T. J. SIMON, Auteur Article en page(s) : p.5 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention. METHODS: Girls with 22q11.2DS, FXS, or TS and typically developing (TD) girls, aged 7 to 15 years, completed an attention network test, a flanker task with alerting and orienting cues. Exploration of reaction times and accuracy allowed us to test for potential commonalities in attentional functioning in alerting, orienting, and executive control. Linear regression models were used to test whether the predictors of group and chronological age were able to predict differences in attention indices. RESULTS: Girls with 22q11.2DS, FXS, or TS demonstrated unimpaired function of the alerting system and impaired function of the executive control system. Diagnosis-specific impairments were found such that girls with FXS made more errors and had a reduced orienting index, while girls with 22q11.2DS showed specific age-related deficits in the executive control system. CONCLUSIONS: These results suggest that the control but not the implementation of attention is selectively impaired in girls with 22q11.2DS, TS or FXS. Additionally, the age effect on executive control in girls with 22q11.2DS implies a possible altered developmental trajectory. En ligne : http://dx.doi.org/10.1186/1866-1955-6-5 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3459 [article] Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes [Texte imprimé et/ou numérique] / A. I. QUINTERO, Auteur ; Elliott A. BEATON, Auteur ; D. J. HARVEY, Auteur ; J. L. ROSS, Auteur ; T. J. SIMON, Auteur . - p.5. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.5 Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention. METHODS: Girls with 22q11.2DS, FXS, or TS and typically developing (TD) girls, aged 7 to 15 years, completed an attention network test, a flanker task with alerting and orienting cues. Exploration of reaction times and accuracy allowed us to test for potential commonalities in attentional functioning in alerting, orienting, and executive control. Linear regression models were used to test whether the predictors of group and chronological age were able to predict differences in attention indices. RESULTS: Girls with 22q11.2DS, FXS, or TS demonstrated unimpaired function of the alerting system and impaired function of the executive control system. Diagnosis-specific impairments were found such that girls with FXS made more errors and had a reduced orienting index, while girls with 22q11.2DS showed specific age-related deficits in the executive control system. CONCLUSIONS: These results suggest that the control but not the implementation of attention is selectively impaired in girls with 22q11.2DS, TS or FXS. Additionally, the age effect on executive control in girls with 22q11.2DS implies a possible altered developmental trajectory. En ligne : http://dx.doi.org/10.1186/1866-1955-6-5 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3459

How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? / Elliott A. BEATON in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.68-75 Titre : How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? Type de document : Texte imprimé et/ou numérique Auteurs : Elliott A. BEATON, Auteur ; T. J. SIMON, Auteur Article en page(s) : p.68-75 Langues : Anglais (eng) Mots-clés : Allostatic load  Children  Cortisol  Developmental disorder  Genotype  Hypothalamic-pituitary-adrenal axis (HPA axis)  Schizophrenia  Socioemotional development  Stress-diathesis  Velo-cardio-facial syndrome (VCFS) Index. décimale : PER Périodiques Résumé : The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has been under investigation for over 30 years (Walker et al. 2008), the stress-diathesis model has yet to be investigated in children with 22q11.2DS. Children with 22q11.2DS face serious medical, behavioral, and socioemotional challenges from infancy into adulthood. Chronic stress elevates glucocorticoids, decreases immunocompetence, negatively impacts brain development and function, and is associated with psychiatric illness in adulthood. Drawing knowledge from the extant and well-developed anxiety and stress literature will provide invaluable insight into the complex etiopathology of schizophrenia in people with 22q11.2DS while suggesting possible early interventions. Childhood anxiety is treatable and stress coping skills can be developed thereby improving quality of life in the short-term and potentially mitigating the risk of developing psychosis. En ligne : http://dx.doi.org/10.1007/s11689-010-9069-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3431 [article] How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? [Texte imprimé et/ou numérique] / Elliott A. BEATON, Auteur ; T. J. SIMON, Auteur . - p.68-75. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.68-75 Mots-clés : Allostatic load  Children  Cortisol  Developmental disorder  Genotype  Hypothalamic-pituitary-adrenal axis (HPA axis)  Schizophrenia  Socioemotional development  Stress-diathesis  Velo-cardio-facial syndrome (VCFS) Index. décimale : PER Périodiques Résumé : The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has been under investigation for over 30 years (Walker et al. 2008), the stress-diathesis model has yet to be investigated in children with 22q11.2DS. Children with 22q11.2DS face serious medical, behavioral, and socioemotional challenges from infancy into adulthood. Chronic stress elevates glucocorticoids, decreases immunocompetence, negatively impacts brain development and function, and is associated with psychiatric illness in adulthood. Drawing knowledge from the extant and well-developed anxiety and stress literature will provide invaluable insight into the complex etiopathology of schizophrenia in people with 22q11.2DS while suggesting possible early interventions. Childhood anxiety is treatable and stress coping skills can be developed thereby improving quality of life in the short-term and potentially mitigating the risk of developing psychosis. En ligne : http://dx.doi.org/10.1007/s11689-010-9069-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3431

Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome / M. H. CABARAL in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.6 Titre : Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome Type de document : Texte imprimé et/ou numérique Auteurs : M. H. CABARAL, Auteur ; Elliott A. BEATON, Auteur ; J. STODDARD, Auteur ; T. J. SIMON, Auteur Article en page(s) : p.6 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 Deletion Syndrome (22q11.2DS) occurs in approximately 1:4,000 live births with a complex and variable presentation that includes medical, socioemotional and psychological symptoms with intellectual impairment. Cognitive impairments in spatiotemporal and visuospatial attention have also been reported. However, maintenance of selective attention to dynamic and interacting objects has not been systematically investigated in children with 22q11.2DS. METHODS: We used a multiple object tracking task to assay capacity and resolution performance of children with 22q11.2DS aged 7 to 14 years versus age-matched typically developing (TD) peers. RESULTS: Children with 22q11.2DS but not TD children demonstrated impaired performance when task demands increased due to an increase in the number of targets presented, but not from an increase in object speed. Task performance in children with 22q11.2DS was also unrelated to intelligence or measures of attention deficit hyperactivity disorder. CONCLUSIONS: These findings suggest that children with 22q11.2DS may be particularly susceptible to dynamic crowding of objects with increasing cognitive demands related to monitoring multiple targets reflecting a reduced acuity in spatiotemporal cognitive representation. En ligne : http://dx.doi.org/10.1186/1866-1955-4-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3443 [article] Impaired multiple object tracking in children with chromosome 22q11.2 deletion syndrome [Texte imprimé et/ou numérique] / M. H. CABARAL, Auteur ; Elliott A. BEATON, Auteur ; J. STODDARD, Auteur ; T. J. SIMON, Auteur . - p.6. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.6 Index. décimale : PER Périodiques Résumé : BACKGROUND: Chromosome 22q11.2 Deletion Syndrome (22q11.2DS) occurs in approximately 1:4,000 live births with a complex and variable presentation that includes medical, socioemotional and psychological symptoms with intellectual impairment. Cognitive impairments in spatiotemporal and visuospatial attention have also been reported. However, maintenance of selective attention to dynamic and interacting objects has not been systematically investigated in children with 22q11.2DS. METHODS: We used a multiple object tracking task to assay capacity and resolution performance of children with 22q11.2DS aged 7 to 14 years versus age-matched typically developing (TD) peers. RESULTS: Children with 22q11.2DS but not TD children demonstrated impaired performance when task demands increased due to an increase in the number of targets presented, but not from an increase in object speed. Task performance in children with 22q11.2DS was also unrelated to intelligence or measures of attention deficit hyperactivity disorder. CONCLUSIONS: These findings suggest that children with 22q11.2DS may be particularly susceptible to dynamic crowding of objects with increasing cognitive demands related to monitoring multiple targets reflecting a reduced acuity in spatiotemporal cognitive representation. En ligne : http://dx.doi.org/10.1186/1866-1955-4-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3443

Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology / Ashley F. P. SANDERS in Journal of Autism and Developmental Disorders, 47-4 (April 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.992-1005 Titre : Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology Type de document : Texte imprimé et/ou numérique Auteurs : Ashley F. P. SANDERS, Auteur ; Diana A. HOBBS, Auteur ; David D. STEPHENSON, Auteur ; Robert D. LAIRD, Auteur ; Elliott A. BEATON, Auteur Article en page(s) : p.992-1005 Langues : Anglais (eng) Mots-clés : Anxiety  Chromosome 22q11.2DS  DiGeorge Syndrome  Stress  Velocardiofacial Syndrome  Working memory Index. décimale : PER Périodiques Résumé : Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s10803-016-3011-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3048 [article] Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology [Texte imprimé et/ou numérique] / Ashley F. P. SANDERS, Auteur ; Diana A. HOBBS, Auteur ; David D. STEPHENSON, Auteur ; Robert D. LAIRD, Auteur ; Elliott A. BEATON, Auteur . - p.992-1005. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.992-1005 Mots-clés : Anxiety  Chromosome 22q11.2DS  DiGeorge Syndrome  Stress  Velocardiofacial Syndrome  Working memory Index. décimale : PER Périodiques Résumé : Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS. En ligne : http://dx.doi.org/10.1007/s10803-016-3011-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3048

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