Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders / Jill ESCHER in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4608-4624 Titre : Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jill ESCHER, Auteur ; Wei YAN, Auteur ; Emilie F. RISSMAN, Auteur ; Hsiao-Lin V. WANG, Auteur ; Arturo HERNANDEZ, Auteur ; Victor G. CORCES, Auteur Article en page(s) : p.4608-4624 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Epigenetics  Gene expression  Genetic toxicology  Germ cells  Non-genetic inheritance Index. décimale : PER Périodiques Résumé : Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route-disruption of the germline epigenome induced by exogenous toxicants during a parent's gamete development. Similar to cases of germline mutation, these molecular perturbations may produce dysregulated transcription of brain-related genes during fetal and early development, resulting in abnormal neurobehavioral phenotypes in offspring. Many types of exposures may have these impacts, and here we discuss examples of anesthetic gases, tobacco components, synthetic steroids, and valproic acid. Alterations in parental germline could help explain some unsolved phenomena of autism, including increased prevalence, missing heritability, skewed sex ratio, and heterogeneity of neurobiology and behavior. En ligne : http://dx.doi.org/10.1007/s10803-021-05304-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jill ESCHER, Auteur ; Wei YAN, Auteur ; Emilie F. RISSMAN, Auteur ; Hsiao-Lin V. WANG, Auteur ; Arturo HERNANDEZ, Auteur ; Victor G. CORCES, Auteur . - p.4608-4624. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4608-4624 Mots-clés : Autism spectrum disorder  Epigenetics  Gene expression  Genetic toxicology  Germ cells  Non-genetic inheritance Index. décimale : PER Périodiques Résumé : Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route-disruption of the germline epigenome induced by exogenous toxicants during a parent's gamete development. Similar to cases of germline mutation, these molecular perturbations may produce dysregulated transcription of brain-related genes during fetal and early development, resulting in abnormal neurobehavioral phenotypes in offspring. Many types of exposures may have these impacts, and here we discuss examples of anesthetic gases, tobacco components, synthetic steroids, and valproic acid. Alterations in parental germline could help explain some unsolved phenomena of autism, including increased prevalence, missing heritability, skewed sex ratio, and heterogeneity of neurobiology and behavior. En ligne : http://dx.doi.org/10.1007/s10803-021-05304-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

A full semantic toolbox is essential for autism research and practice to thrive / Alison SINGER in Autism Research, 16-3 (March 2023)  

Public ISBD [article]  inAutism Research > 16-3 (March 2023) . - p.497-501 Titre : A full semantic toolbox is essential for autism research and practice to thrive Type de document : Texte imprimé et/ou numérique Auteurs : Alison SINGER, Auteur ; Amy LUTZ, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.497-501 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism spectrum disorder (ASD) present with a highly diverse set of challenges, disabilities, impairments and strengths. Recently, it has been suggested that researchers and practitioners avoid using certain words to describe the difficulties and impairments experienced by individuals with ASD to reduce stigma. The proposed limitations on terminology were developed by only a subset of the autism community, and the recommendations are already causing negative consequences that may be harmful to future scientific and clinical endeavors and, ultimately, to people with ASD. No one should have the power to censor language to exclude the observable realities of autism. Scientists and clinicians must be able to use any scientifically accurate terms necessary to describe the wide range of autistic people they study and support, without fear of censure or retribution. En ligne : https://doi.org/10.1002/aur.2876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 [article] A full semantic toolbox is essential for autism research and practice to thrive [Texte imprimé et/ou numérique] / Alison SINGER, Auteur ; Amy LUTZ, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur . - p.497-501. Langues : Anglais (eng) in Autism Research > 16-3 (March 2023) . - p.497-501 Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism spectrum disorder (ASD) present with a highly diverse set of challenges, disabilities, impairments and strengths. Recently, it has been suggested that researchers and practitioners avoid using certain words to describe the difficulties and impairments experienced by individuals with ASD to reduce stigma. The proposed limitations on terminology were developed by only a subset of the autism community, and the recommendations are already causing negative consequences that may be harmful to future scientific and clinical endeavors and, ultimately, to people with ASD. No one should have the power to censor language to exclude the observable realities of autism. Scientists and clinicians must be able to use any scientifically accurate terms necessary to describe the wide range of autistic people they study and support, without fear of censure or retribution. En ligne : https://doi.org/10.1002/aur.2876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498

Response to letter from Ryan Collis / Amy LUTZ in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.681-681 Titre : Response to letter from Ryan Collis Type de document : Texte imprimé et/ou numérique Auteurs : Amy LUTZ, Auteur ; Alison SINGER, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.681-681 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Response to letter from Ryan Collis [Texte imprimé et/ou numérique] / Amy LUTZ, Auteur ; Alison SINGER, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur . - p.681-681. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.681-681 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Response to Natri / Alison SINGER in Autism Research, 16-4 (April 2023)  

Public ISBD [article]  inAutism Research > 16-4 (April 2023) . - p.677-677 Titre : Response to Natri Type de document : Texte imprimé et/ou numérique Auteurs : Alison SINGER, Auteur ; Jill ESCHER, Auteur ; Amy LUTZ, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.677-677 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Response to Natri [Texte imprimé et/ou numérique] / Alison SINGER, Auteur ; Jill ESCHER, Auteur ; Amy LUTZ, Auteur ; Alycia HALLADAY, Auteur . - p.677-677. Langues : Anglais (eng) in Autism Research > 16-4 (April 2023) . - p.677-677 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.2925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

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