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Autism Research . 16-3Paru le : 01/03/2023 |
[n° ou bulletin]
[n° ou bulletin] 16-3 - March 2023 [Texte imprimé et/ou numérique] . - 2023. Langues : Anglais (eng)
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Ajouter le résultat dans votre panierEvidence from the Autism Transitions Research Project (2017-2022): Capstone review and services research recommendations / Anne M. ROUX in Autism Research, 16-3 (March 2023)
[article]
Titre : Evidence from the Autism Transitions Research Project (2017-2022): Capstone review and services research recommendations Type de document : Texte imprimé et/ou numérique Auteurs : Anne M. ROUX, Auteur ; Lindsay L. SHEA, Auteur ; Hillary STEINBERG, Auteur ; Jessica E. RAST, Auteur ; Kristy A. ANDERSON, Auteur ; Emily HOTEZ, Auteur ; Kashia ROSENAU, Auteur ; Alice KUO, Auteur ; Evva ASSING-MURRAY, Auteur ; Paul T. SHATTUCK, Auteur Article en page(s) : p.480-496 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Few funding sources have explicitly supported systems-wide research to identify mechanisms for improving access, service delivery, outcomes and wellbeing for autistic transition-age youth and young adults. We aimed to integrate findings from research produced through a five-year federal Autism Transition Research Project (ATRP) cooperative agreement. This capstone review sought to: (1) map the body of scientific evidence that emerged from this federal award, and (2) identify remaining evidence gaps to inform future autism transition services research. We used scoping review methods to assess 31 ATRP-funded published scientific studies. We charted study characteristics, topical domains, socio-ecological levels of variables, focus on equity, and inclusion of autistic participants. We evaluated how these topics were addressed across studies to identify continued gaps in the evidence base. Compared to prior published reviews and research agendas, we found improvements in characterization of study participants, broader examination of socio-ecological correlates, and examination of multiple outcome domains. However, we also identified continued deficits in inclusion of autistic study participants, use of multisectoral data, and research with a strong focus on equity. Our recommended priorities for autism transition services research to facilitate healthy life outcomes and wellbeing included: continued analysis of population-level data and improved data infrastructure; development of service delivery methods and interventions that target marginalized groups; expanded research to inform improvements in the performance and coordination of complex service ecosystems that interface with autistic youth; and bolstering the roles of autistic research participants. En ligne : https://doi.org/10.1002/aur.2890 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.480-496[article] Evidence from the Autism Transitions Research Project (2017-2022): Capstone review and services research recommendations [Texte imprimé et/ou numérique] / Anne M. ROUX, Auteur ; Lindsay L. SHEA, Auteur ; Hillary STEINBERG, Auteur ; Jessica E. RAST, Auteur ; Kristy A. ANDERSON, Auteur ; Emily HOTEZ, Auteur ; Kashia ROSENAU, Auteur ; Alice KUO, Auteur ; Evva ASSING-MURRAY, Auteur ; Paul T. SHATTUCK, Auteur . - p.480-496.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.480-496
Index. décimale : PER Périodiques Résumé : Abstract Few funding sources have explicitly supported systems-wide research to identify mechanisms for improving access, service delivery, outcomes and wellbeing for autistic transition-age youth and young adults. We aimed to integrate findings from research produced through a five-year federal Autism Transition Research Project (ATRP) cooperative agreement. This capstone review sought to: (1) map the body of scientific evidence that emerged from this federal award, and (2) identify remaining evidence gaps to inform future autism transition services research. We used scoping review methods to assess 31 ATRP-funded published scientific studies. We charted study characteristics, topical domains, socio-ecological levels of variables, focus on equity, and inclusion of autistic participants. We evaluated how these topics were addressed across studies to identify continued gaps in the evidence base. Compared to prior published reviews and research agendas, we found improvements in characterization of study participants, broader examination of socio-ecological correlates, and examination of multiple outcome domains. However, we also identified continued deficits in inclusion of autistic study participants, use of multisectoral data, and research with a strong focus on equity. Our recommended priorities for autism transition services research to facilitate healthy life outcomes and wellbeing included: continued analysis of population-level data and improved data infrastructure; development of service delivery methods and interventions that target marginalized groups; expanded research to inform improvements in the performance and coordination of complex service ecosystems that interface with autistic youth; and bolstering the roles of autistic research participants. En ligne : https://doi.org/10.1002/aur.2890 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 A full semantic toolbox is essential for autism research and practice to thrive / Alison SINGER in Autism Research, 16-3 (March 2023)
[article]
Titre : A full semantic toolbox is essential for autism research and practice to thrive Type de document : Texte imprimé et/ou numérique Auteurs : Alison SINGER, Auteur ; Amy LUTZ, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.497-501 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism spectrum disorder (ASD) present with a highly diverse set of challenges, disabilities, impairments and strengths. Recently, it has been suggested that researchers and practitioners avoid using certain words to describe the difficulties and impairments experienced by individuals with ASD to reduce stigma. The proposed limitations on terminology were developed by only a subset of the autism community, and the recommendations are already causing negative consequences that may be harmful to future scientific and clinical endeavors and, ultimately, to people with ASD. No one should have the power to censor language to exclude the observable realities of autism. Scientists and clinicians must be able to use any scientifically accurate terms necessary to describe the wide range of autistic people they study and support, without fear of censure or retribution. En ligne : https://doi.org/10.1002/aur.2876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.497-501[article] A full semantic toolbox is essential for autism research and practice to thrive [Texte imprimé et/ou numérique] / Alison SINGER, Auteur ; Amy LUTZ, Auteur ; Jill ESCHER, Auteur ; Alycia HALLADAY, Auteur . - p.497-501.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.497-501
Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism spectrum disorder (ASD) present with a highly diverse set of challenges, disabilities, impairments and strengths. Recently, it has been suggested that researchers and practitioners avoid using certain words to describe the difficulties and impairments experienced by individuals with ASD to reduce stigma. The proposed limitations on terminology were developed by only a subset of the autism community, and the recommendations are already causing negative consequences that may be harmful to future scientific and clinical endeavors and, ultimately, to people with ASD. No one should have the power to censor language to exclude the observable realities of autism. Scientists and clinicians must be able to use any scientifically accurate terms necessary to describe the wide range of autistic people they study and support, without fear of censure or retribution. En ligne : https://doi.org/10.1002/aur.2876 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder / Stephen K. SIECINSKI in Autism Research, 16-3 (March 2023)
[article]
Titre : Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephen K. SIECINSKI, Auteur ; Stephanie N. GIAMBERARDINO, Auteur ; Marina SPANOS, Auteur ; Annalise C. HAUSER, Auteur ; Jason R. GIBSON, Auteur ; Tara CHANDRASEKHAR, Auteur ; Maria Del Pilar TRELLES, Auteur ; Carol M. ROCKHILL, Auteur ; Michelle L. PALUMBO, Auteur ; Allyson Witters CUNDIFF, Auteur ; Alicia MONTGOMERY, Auteur ; Paige SIPER, Auteur ; Mendy MINJAREZ, Auteur ; Lisa A. NOWINSKI, Auteur ; Sarah MARLER, Auteur ; Lydia C. KWEE, Auteur ; Lauren C. SHUFFREY, Auteur ; Cheryl ALDERMAN, Auteur ; Jordana WEISSMAN, Auteur ; Brooke ZAPPONE, Auteur ; Jennifer E. MULLETT, Auteur ; Hope CROSSON, Auteur ; Natalie HONG, Auteur ; Sheng LUO, Auteur ; Lilin SHE, Auteur ; Manjushri BHAPKAR, Auteur ; Russell DEAN, Auteur ; Abby SCHEER, Auteur ; Jacqueline L. JOHNSON, Auteur ; Bryan H. KING, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin B. SANDERS, Auteur ; Soo-Jeong KIM, Auteur ; Alexander KOLEVZON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Elizabeth R. HAUSER, Auteur ; Linmarie SIKICH, Auteur ; Simon G. GREGORY, Auteur Article en page(s) : p.502-523 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We investigated whether genetic and epigenetic variation contribute to variable endogenous OT levels that modulate sensitivity to OT therapy. To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT. Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes. We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA-methylation profiles across several annotated gene sets. These findings broaden our understanding of the effects of the peripheral oxytocin system and provide novel genetic candidates for future studies to decode the complex etiology of ASD and its interaction with OT signaling and OT-based interventions. Lay Summary Oxytocin (OT) is an abundant chemical produced by neurons that plays an important role in social interaction and motivation. We investigated whether genetic and epigenetic factors contribute to variable OT levels in the blood. To this, we integrated genetic, gene expression, and non-DNA regulated (epigenetic) signatures with blood OT levels in 290 participants with autism enrolled in an OT clinical trial. We identified genetic association with plasma OT, several of which reside in known autism risk genes. We also show statistically significant association of plasma OT levels with gene expression and epigenetic across several gene pathways. These findings broaden our understanding of the factors that influence OT levels in the blood for future studies to decode the complex presentation of autism and its interaction with OT and OT-based treatment. En ligne : https://doi.org/10.1002/aur.2884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.502-523[article] Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Stephen K. SIECINSKI, Auteur ; Stephanie N. GIAMBERARDINO, Auteur ; Marina SPANOS, Auteur ; Annalise C. HAUSER, Auteur ; Jason R. GIBSON, Auteur ; Tara CHANDRASEKHAR, Auteur ; Maria Del Pilar TRELLES, Auteur ; Carol M. ROCKHILL, Auteur ; Michelle L. PALUMBO, Auteur ; Allyson Witters CUNDIFF, Auteur ; Alicia MONTGOMERY, Auteur ; Paige SIPER, Auteur ; Mendy MINJAREZ, Auteur ; Lisa A. NOWINSKI, Auteur ; Sarah MARLER, Auteur ; Lydia C. KWEE, Auteur ; Lauren C. SHUFFREY, Auteur ; Cheryl ALDERMAN, Auteur ; Jordana WEISSMAN, Auteur ; Brooke ZAPPONE, Auteur ; Jennifer E. MULLETT, Auteur ; Hope CROSSON, Auteur ; Natalie HONG, Auteur ; Sheng LUO, Auteur ; Lilin SHE, Auteur ; Manjushri BHAPKAR, Auteur ; Russell DEAN, Auteur ; Abby SCHEER, Auteur ; Jacqueline L. JOHNSON, Auteur ; Bryan H. KING, Auteur ; Christopher J. MCDOUGLE, Auteur ; Kevin B. SANDERS, Auteur ; Soo-Jeong KIM, Auteur ; Alexander KOLEVZON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Elizabeth R. HAUSER, Auteur ; Linmarie SIKICH, Auteur ; Simon G. GREGORY, Auteur . - p.502-523.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.502-523
Index. décimale : PER Périodiques Résumé : Abstract Oxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We investigated whether genetic and epigenetic variation contribute to variable endogenous OT levels that modulate sensitivity to OT therapy. To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT. Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes. We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA-methylation profiles across several annotated gene sets. These findings broaden our understanding of the effects of the peripheral oxytocin system and provide novel genetic candidates for future studies to decode the complex etiology of ASD and its interaction with OT signaling and OT-based interventions. Lay Summary Oxytocin (OT) is an abundant chemical produced by neurons that plays an important role in social interaction and motivation. We investigated whether genetic and epigenetic factors contribute to variable OT levels in the blood. To this, we integrated genetic, gene expression, and non-DNA regulated (epigenetic) signatures with blood OT levels in 290 participants with autism enrolled in an OT clinical trial. We identified genetic association with plasma OT, several of which reside in known autism risk genes. We also show statistically significant association of plasma OT levels with gene expression and epigenetic across several gene pathways. These findings broaden our understanding of the factors that influence OT levels in the blood for future studies to decode the complex presentation of autism and its interaction with OT and OT-based treatment. En ligne : https://doi.org/10.1002/aur.2884 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish / Fei LONG in Autism Research, 16-3 (March 2023)
[article]
Titre : Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish Type de document : Texte imprimé et/ou numérique Auteurs : Fei LONG, Auteur ; Jing ZHENG, Auteur ; Jiayi ZHOU, Auteur ; Ping HU, Auteur ; Bo XIONG, Auteur Article en page(s) : p.524-534 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Tanc2 is a large multi-domain postsynaptic scaffold protein mainly expressed in the brain. In humans, tanc2 mutations have been associated with autism spectrum disorder (ASD) and other related neurodevelopmental disorders. However, the role of tanc2 in neurodevelopment and in controlling behaviors are not fully understood. Here, we generated and characterized a tanc2 knockout allele in zebrafish. Loss of tanc2 increases the larval brain size and body length by promoting proliferation and inhibiting apoptosis. We observed that the glutamatergic neuron population is significantly increased in tanc2 mutants while the GABAergic and the glycinergic neurons are not affected, suggesting that an excitatory/inhibitory (E/I) imbalance. Indeed, the tanc2 knockout larvae exhibited increase sleep. In adult zebrafish, the mutants display anxiolytic-behavior, reduced aggression, and impaired social preference. The alterations in these behaviors are phenotypically similar to the ASD patients carrying tanc2 mutations. Therefore, the tanc2 knockout allele could serve as a valuable model to further study the role of tanc2 in the nervous system. En ligne : https://doi.org/10.1002/aur.2880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.524-534[article] Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish [Texte imprimé et/ou numérique] / Fei LONG, Auteur ; Jing ZHENG, Auteur ; Jiayi ZHOU, Auteur ; Ping HU, Auteur ; Bo XIONG, Auteur . - p.524-534.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.524-534
Index. décimale : PER Périodiques Résumé : Abstract Tanc2 is a large multi-domain postsynaptic scaffold protein mainly expressed in the brain. In humans, tanc2 mutations have been associated with autism spectrum disorder (ASD) and other related neurodevelopmental disorders. However, the role of tanc2 in neurodevelopment and in controlling behaviors are not fully understood. Here, we generated and characterized a tanc2 knockout allele in zebrafish. Loss of tanc2 increases the larval brain size and body length by promoting proliferation and inhibiting apoptosis. We observed that the glutamatergic neuron population is significantly increased in tanc2 mutants while the GABAergic and the glycinergic neurons are not affected, suggesting that an excitatory/inhibitory (E/I) imbalance. Indeed, the tanc2 knockout larvae exhibited increase sleep. In adult zebrafish, the mutants display anxiolytic-behavior, reduced aggression, and impaired social preference. The alterations in these behaviors are phenotypically similar to the ASD patients carrying tanc2 mutations. Therefore, the tanc2 knockout allele could serve as a valuable model to further study the role of tanc2 in the nervous system. En ligne : https://doi.org/10.1002/aur.2880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders / Elizabeth W. PANG in Autism Research, 16-3 (March 2023)
[article]
Titre : Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth W. PANG, Auteur ; Chris HAMMILL, Auteur ; Margot J. TAYLOR, Auteur ; Jamie NEAR, Auteur ; Russell SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Paul D. ARNOLD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain. Recent evidence has shown the involvement of the cerebellum in cognition and affect regulation, and cerebellar atypical function or damage is reported frequently in NDDs. Magnetic resonance spectroscopy studies have reported decreases in GABA in cortical brain areas in the NDDs, however, GABA levels in the cerebellum have not been examined. To determine possible group effects, we used a MEGA-PRESS acquisition to investigate GABA+ levels in a cerebellar voxel in 343 individuals (aged 2.5-22?years) with ASD, ADHD, OCD and controls. Using a mixed effects model, we found no significant differences between groups in GABA+ concentration. Our findings suggest that cerebellar GABA+ levels do not differentiate NDD groups. En ligne : https://doi.org/10.1002/aur.2888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.535-542[article] Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders [Texte imprimé et/ou numérique] / Elizabeth W. PANG, Auteur ; Chris HAMMILL, Auteur ; Margot J. TAYLOR, Auteur ; Jamie NEAR, Auteur ; Russell SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Paul D. ARNOLD, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jason P. LERCH, Auteur . - p.535-542.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.535-542
Index. décimale : PER Périodiques Résumé : Abstract Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (GABA) and glutamate in the brain. Recent evidence has shown the involvement of the cerebellum in cognition and affect regulation, and cerebellar atypical function or damage is reported frequently in NDDs. Magnetic resonance spectroscopy studies have reported decreases in GABA in cortical brain areas in the NDDs, however, GABA levels in the cerebellum have not been examined. To determine possible group effects, we used a MEGA-PRESS acquisition to investigate GABA+ levels in a cerebellar voxel in 343 individuals (aged 2.5-22?years) with ASD, ADHD, OCD and controls. Using a mixed effects model, we found no significant differences between groups in GABA+ concentration. Our findings suggest that cerebellar GABA+ levels do not differentiate NDD groups. En ligne : https://doi.org/10.1002/aur.2888 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals / Nicholas E. FEARS in Autism Research, 16-3 (March 2023)
[article]
Titre : Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas E. FEARS, Auteur ; Gabriela M.c SHERROD, Auteur ; Tylan N. TEMPLIN, Auteur ; Nicoleta L. BUGNARIU, Auteur ; Rita M. PATTERSON, Auteur ; Haylie L. MILLER, Auteur Article en page(s) : p.543-557 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals exhibit significant sensorimotor differences. Postural stability and control are foundational motor skills for successfully performing many activities of daily living. In neurotypical development, postural stability and control develop throughout childhood and adolescence. In autistic development, previous studies have focused primarily on individual age groups (e.g., childhood, adolescence, adulthood) or only controlled for age using age-matching. Here, we examined the age trajectories of postural stability and control in autism from childhood through adolescents using standardized clinical assessments. In study 1, we tested the postural stability of autistic (n = 27) and neurotypical (n = 41) children, adolescents, and young adults aged 7-20?years during quiet standing on a force plate in three visual conditions: eyes open (EO), eyes closed (EC), and eyes open with the head in a translucent dome (Dome). Postural sway variability decreased as age increased for both groups, but autistic participants showed greater variability than neurotypical participants across age. In study 2, we tested autistic (n = 21) and neurotypical (n = 32) children and adolescents aged 7-16?years during a dynamic postural control task with nine targets. Postural control efficiency increased as age increased for both groups, but autistic participants were less efficient compared to neurotypical participants across age. Together, these results indicate that autistic individuals have a similar age trajectory for postural stability and control compared to neurotypical individuals, but have lower postural stability and control overall. En ligne : https://doi.org/10.1002/aur.2889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.543-557[article] Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals [Texte imprimé et/ou numérique] / Nicholas E. FEARS, Auteur ; Gabriela M.c SHERROD, Auteur ; Tylan N. TEMPLIN, Auteur ; Nicoleta L. BUGNARIU, Auteur ; Rita M. PATTERSON, Auteur ; Haylie L. MILLER, Auteur . - p.543-557.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.543-557
Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals exhibit significant sensorimotor differences. Postural stability and control are foundational motor skills for successfully performing many activities of daily living. In neurotypical development, postural stability and control develop throughout childhood and adolescence. In autistic development, previous studies have focused primarily on individual age groups (e.g., childhood, adolescence, adulthood) or only controlled for age using age-matching. Here, we examined the age trajectories of postural stability and control in autism from childhood through adolescents using standardized clinical assessments. In study 1, we tested the postural stability of autistic (n = 27) and neurotypical (n = 41) children, adolescents, and young adults aged 7-20?years during quiet standing on a force plate in three visual conditions: eyes open (EO), eyes closed (EC), and eyes open with the head in a translucent dome (Dome). Postural sway variability decreased as age increased for both groups, but autistic participants showed greater variability than neurotypical participants across age. In study 2, we tested autistic (n = 21) and neurotypical (n = 32) children and adolescents aged 7-16?years during a dynamic postural control task with nine targets. Postural control efficiency increased as age increased for both groups, but autistic participants were less efficient compared to neurotypical participants across age. Together, these results indicate that autistic individuals have a similar age trajectory for postural stability and control compared to neurotypical individuals, but have lower postural stability and control overall. En ligne : https://doi.org/10.1002/aur.2889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 ''Why do they do it?'': The short-story task for measuring fiction-based mentalizing in autistic and non-autistic individuals / Irina JARVERS in Autism Research, 16-3 (March 2023)
[article]
Titre : ''Why do they do it?'': The short-story task for measuring fiction-based mentalizing in autistic and non-autistic individuals Type de document : Texte imprimé et/ou numérique Auteurs : Irina JARVERS, Auteur ; Katrin DÖHNEL, Auteur ; Lore BLAAS, Auteur ; Manuela ULLMANN, Auteur ; Berthold LANGGUTH, Auteur ; Rainer RUPPRECHT, Auteur ; Monika SOMMER, Auteur Article en page(s) : p.558-568 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study aimed to validate the short-story-task (SST) based on Dodell-Feder et al. as an instrument to quantify the ability of mentalizing and to differentiate between non-autistic adults and autistic adults, who may have acquired rules to interpret the actions of non-autistic individuals. Autistic (N = 32) and non-autistic (N = 32) adult participants were asked to read ''The End of Something'' by Ernest Hemingway and to answer implicit and explicit mentalizing questions, and comprehension questions. Furthermore, verbal and nonverbal IQ was measured and participants were asked how much fiction they read each month. Mentalizing performance was normally distributed for autistic and non-autistic participants with autistic participants scoring in the lower third of the distribution. ROC (receiver operator curve) analysis revealed the task to be an excellent discriminator between autistic and non-autistic participants. A linear regression analysis identified number of books read, years of education and group as significant predictors. Overall, the SST is a promising measure of mentalizing. On the one hand, it differentiates among non-autistic individuals and on the other hand it is sensitive towards performance differences in mentalizing among autistic adults. Implications for interventions are discussed. En ligne : https://doi.org/10.1002/aur.2871 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.558-568[article] ''Why do they do it?'': The short-story task for measuring fiction-based mentalizing in autistic and non-autistic individuals [Texte imprimé et/ou numérique] / Irina JARVERS, Auteur ; Katrin DÖHNEL, Auteur ; Lore BLAAS, Auteur ; Manuela ULLMANN, Auteur ; Berthold LANGGUTH, Auteur ; Rainer RUPPRECHT, Auteur ; Monika SOMMER, Auteur . - p.558-568.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.558-568
Index. décimale : PER Périodiques Résumé : Abstract This study aimed to validate the short-story-task (SST) based on Dodell-Feder et al. as an instrument to quantify the ability of mentalizing and to differentiate between non-autistic adults and autistic adults, who may have acquired rules to interpret the actions of non-autistic individuals. Autistic (N = 32) and non-autistic (N = 32) adult participants were asked to read ''The End of Something'' by Ernest Hemingway and to answer implicit and explicit mentalizing questions, and comprehension questions. Furthermore, verbal and nonverbal IQ was measured and participants were asked how much fiction they read each month. Mentalizing performance was normally distributed for autistic and non-autistic participants with autistic participants scoring in the lower third of the distribution. ROC (receiver operator curve) analysis revealed the task to be an excellent discriminator between autistic and non-autistic participants. A linear regression analysis identified number of books read, years of education and group as significant predictors. Overall, the SST is a promising measure of mentalizing. On the one hand, it differentiates among non-autistic individuals and on the other hand it is sensitive towards performance differences in mentalizing among autistic adults. Implications for interventions are discussed. En ligne : https://doi.org/10.1002/aur.2871 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use / Lauren BISHOP in Autism Research, 16-3 (March 2023)
[article]
Titre : Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP, Auteur ; Rebecca A. CHARLTON, Auteur ; Kiley J. MCLEAN, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.569-579 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Approximately 40% of American adults are affected by cardiovascular disease (CVD) risk factors (e.g., high blood pressure, high cholesterol, diabetes, and overweight or obesity), and risk among autistic adults may be even higher. Mechanisms underlying the high prevalence of CVD risk factors in autistic people may include known correlates of CVD risk factors in other groups, including high levels of perceived stress, poor sleep quality, and antipsychotic medication use. A sample of 545 autistic adults without intellectual disability aged 18+ were recruited through the Simons Foundation Powering Autism Research, Research Match. Multiple linear regression models examined the association between key independent variables (self-reported perceived stress, sleep quality, and antipsychotic medication use) and CVD risk factors, controlling for demographic variables (age, sex assigned at birth, race, low-income status, autistic traits). Overall, 73.2% of autistic adults in our sample had an overweight/obesity classification, 45.3% had high cholesterol, 39.4% had high blood pressure, and 10.3% had diabetes. Older age, male sex assigned at birth, and poorer sleep quality were associated with a higher number of CVD risk factors. Using antipsychotic medications was associated with an increased likelihood of having diabetes. Poorer sleep quality was associated with an increased likelihood of having an overweight/obesity classification. Self-reported CVD risk factors are highly prevalent among autistic adults. Both improving sleep quality and closely monitoring CVD risk factors among autistic adults who use antipsychotic medications have the potential to reduce risk for CVD. En ligne : https://doi.org/10.1002/aur.2872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.569-579[article] Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use [Texte imprimé et/ou numérique] / Lauren BISHOP, Auteur ; Rebecca A. CHARLTON, Auteur ; Kiley J. MCLEAN, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.569-579.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.569-579
Index. décimale : PER Périodiques Résumé : Abstract Approximately 40% of American adults are affected by cardiovascular disease (CVD) risk factors (e.g., high blood pressure, high cholesterol, diabetes, and overweight or obesity), and risk among autistic adults may be even higher. Mechanisms underlying the high prevalence of CVD risk factors in autistic people may include known correlates of CVD risk factors in other groups, including high levels of perceived stress, poor sleep quality, and antipsychotic medication use. A sample of 545 autistic adults without intellectual disability aged 18+ were recruited through the Simons Foundation Powering Autism Research, Research Match. Multiple linear regression models examined the association between key independent variables (self-reported perceived stress, sleep quality, and antipsychotic medication use) and CVD risk factors, controlling for demographic variables (age, sex assigned at birth, race, low-income status, autistic traits). Overall, 73.2% of autistic adults in our sample had an overweight/obesity classification, 45.3% had high cholesterol, 39.4% had high blood pressure, and 10.3% had diabetes. Older age, male sex assigned at birth, and poorer sleep quality were associated with a higher number of CVD risk factors. Using antipsychotic medications was associated with an increased likelihood of having diabetes. Poorer sleep quality was associated with an increased likelihood of having an overweight/obesity classification. Self-reported CVD risk factors are highly prevalent among autistic adults. Both improving sleep quality and closely monitoring CVD risk factors among autistic adults who use antipsychotic medications have the potential to reduce risk for CVD. En ligne : https://doi.org/10.1002/aur.2872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 A comparison of self-report and discrepancy measures of camouflaging: Exploring sex differences in diagnosed autistic versus high autistic trait young adults / Victoria MILNER in Autism Research, 16-3 (March 2023)
[article]
Titre : A comparison of self-report and discrepancy measures of camouflaging: Exploring sex differences in diagnosed autistic versus high autistic trait young adults Type de document : Texte imprimé et/ou numérique Auteurs : Victoria MILNER, Auteur ; Emma COLVERT, Auteur ; William MANDY, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.580-590 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Camouflaging describes masking or compensating for autistic traits and/or related difficulties. Some evidence suggests autistic females camouflage more than autistic males, potentially contributing to delayed or missed diagnosis. Studies predominantly adopt self-report measures of camouflaging, potentially reflecting a person's intent to camouflage without accurately measuring effectiveness (i.e., success in fulfilling the intended effect of minimizing the appearance of autistic traits) of camouflaging. Discrepancy scores between underlying cognitive difficulties (e.g., theory of mind) and observed autistic traits (henceforth camoToM), or between self-reported autistic traits and observed autistic traits (henceforth camoSRS), may provide a more accurate measure of camouflaging effectiveness. Three measures of camouflaging administered to autistic males (n = 46) and females (n = 40), and adults with equally high levels of autistic traits but no diagnosis (n = 45 males, n = 43 females) recruited from a large population-based sample were compared. Self-report measures of camouflaging were significantly correlated with camoSRS scores only. Both discrepancy scores were correlated with each other. Adults with high autistic traits, but no diagnosis, had higher discrepancy camouflaging scores than diagnosed adults, but self-reported scores were similar. Diagnosed females scored higher than diagnosed males across all camouflaging measures, but no sex difference occurred in the high trait group. This might indicate that autistic females have higher intentions and greater effectiveness when camouflaging, compared with autistic males. For camoSRS only, high trait males scored significantly higher than diagnosed males; no group difference occurred for females. These results suggest that, despite all participants intending to camouflage to some extent, effective camouflaging as measured by discrepancy scores is higher in undiagnosed high autistic trait individuals. One interpretation is that effective camouflaging reduces the likelihood of autism diagnosis in males and females with high autistic traits. En ligne : https://doi.org/10.1002/aur.2873 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.580-590[article] A comparison of self-report and discrepancy measures of camouflaging: Exploring sex differences in diagnosed autistic versus high autistic trait young adults [Texte imprimé et/ou numérique] / Victoria MILNER, Auteur ; Emma COLVERT, Auteur ; William MANDY, Auteur ; Francesca HAPPE, Auteur . - p.580-590.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.580-590
Index. décimale : PER Périodiques Résumé : Abstract Camouflaging describes masking or compensating for autistic traits and/or related difficulties. Some evidence suggests autistic females camouflage more than autistic males, potentially contributing to delayed or missed diagnosis. Studies predominantly adopt self-report measures of camouflaging, potentially reflecting a person's intent to camouflage without accurately measuring effectiveness (i.e., success in fulfilling the intended effect of minimizing the appearance of autistic traits) of camouflaging. Discrepancy scores between underlying cognitive difficulties (e.g., theory of mind) and observed autistic traits (henceforth camoToM), or between self-reported autistic traits and observed autistic traits (henceforth camoSRS), may provide a more accurate measure of camouflaging effectiveness. Three measures of camouflaging administered to autistic males (n = 46) and females (n = 40), and adults with equally high levels of autistic traits but no diagnosis (n = 45 males, n = 43 females) recruited from a large population-based sample were compared. Self-report measures of camouflaging were significantly correlated with camoSRS scores only. Both discrepancy scores were correlated with each other. Adults with high autistic traits, but no diagnosis, had higher discrepancy camouflaging scores than diagnosed adults, but self-reported scores were similar. Diagnosed females scored higher than diagnosed males across all camouflaging measures, but no sex difference occurred in the high trait group. This might indicate that autistic females have higher intentions and greater effectiveness when camouflaging, compared with autistic males. For camoSRS only, high trait males scored significantly higher than diagnosed males; no group difference occurred for females. These results suggest that, despite all participants intending to camouflage to some extent, effective camouflaging as measured by discrepancy scores is higher in undiagnosed high autistic trait individuals. One interpretation is that effective camouflaging reduces the likelihood of autism diagnosis in males and females with high autistic traits. En ligne : https://doi.org/10.1002/aur.2873 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits / Lacey CHETCUTI in Autism Research, 16-3 (March 2023)
[article]
Titre : Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits Type de document : Texte imprimé et/ou numérique Auteurs : Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur Article en page(s) : p.591-604 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.591-604[article] Continuity of temperament subgroup classifications from infancy to toddlerhood in the context of early autism traits [Texte imprimé et/ou numérique] / Lacey CHETCUTI, Auteur ; Mirko ULJAREVI?, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Stefanie DIMOV, Auteur ; Sarah PILLAR, Auteur ; Josephine BARBARO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur ; the AICES TEAM, Auteur . - p.591-604.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.591-604
Index. décimale : PER Périodiques Résumé : Abstract Our previous cross-sectional investigation (Chetcuti et al., 2020) showed that infants with autism traits could be divided into distinct subgroups based on temperament. This longitudinal study builds on this existing work by exploring the continuity of temperament subgroup classifications and their associations with behavioral/clinical phenotypic features from infancy to toddlerhood. 103 infants (68% male) showing early signs of autism were referred to the study by community healthcare professionals and seen for assessments when aged around 12-months (Time 1), 18-months (Time 2), and 24-months (Time 3). Latent profile analysis revealed inhibited/low positive, active/negative reactive, and sociable/well-regulated subgroups at each timepoint, and a unique reactive/regulated subgroup at Time 3. Cross-tabulations indicated a significant likelihood of children having a recurrent subgroup classification from one timepoint to the next, and no apparent patterns to the movement of children who did change from one subgroup to another over time. Temperament subgroups were associated with concurrent child social-emotional functioning and autism traits, but unrelated to child age, sex, or developmental level. These findings suggest that temperament subgroup classifications might represent a reliable and very early indicator of autism characteristics and social-emotional functioning among infants/toddlers with autism traits. En ligne : https://doi.org/10.1002/aur.2874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Self-reported cognitive decline among middle and older age autistic adults / Claire B. KLEIN in Autism Research, 16-3 (March 2023)
[article]
Titre : Self-reported cognitive decline among middle and older age autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Claire B. KLEIN, Auteur ; Goldie A. MCQUAID, Auteur ; Rebecca A. CHARLTON, Auteur ; Laura G. KLINGER, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.605-616 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Very little is known about autistic adults as they age. Early evidence suggests a potentially high risk for dementia and atypical cognitive decline in autistic middle and older age adults. Research in the general population indicates that self-reported cognitive decline may predict future dementia earlier than performance-based measures. Nevertheless, self-report dementia screeners have not been used to date in autism research. In a sample of middle and older age autistic adults (N = 210), participants completed a self-rated dementia screener, the AD8, to describe the rate of cognitive decline, examine associations of cognitive decline with age, educational level, sex designated at birth, and autistic traits, and document the psychometrics of a dementia screener in autistic adults. We found high rates of cognitive decline with 30% of the sample screening positive. The most common symptoms were declining interest in leisure activities, and increases in everyday problems with thinking, memory, and judgment. There was evidence that autistic individuals designated female at birth may be more vulnerable to cognitive decline than autistic individuals designated male at birth. Notably, reports of cognitive decline did not vary by age or educational level. Modestly elevated autistic traits were found in those screening positive versus negative for cognitive decline. Finally, the dementia screener showed good psychometrics, including convergent validity with an independent measure of current memory problems. These results could signal an emerging public health crisis in autistic adults as they age, and support the potential utility of self-report measures for early screening for cognitive decline in this population. En ligne : https://doi.org/10.1002/aur.2877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.605-616[article] Self-reported cognitive decline among middle and older age autistic adults [Texte imprimé et/ou numérique] / Claire B. KLEIN, Auteur ; Goldie A. MCQUAID, Auteur ; Rebecca A. CHARLTON, Auteur ; Laura G. KLINGER, Auteur ; Gregory L. WALLACE, Auteur . - p.605-616.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.605-616
Index. décimale : PER Périodiques Résumé : Abstract Very little is known about autistic adults as they age. Early evidence suggests a potentially high risk for dementia and atypical cognitive decline in autistic middle and older age adults. Research in the general population indicates that self-reported cognitive decline may predict future dementia earlier than performance-based measures. Nevertheless, self-report dementia screeners have not been used to date in autism research. In a sample of middle and older age autistic adults (N = 210), participants completed a self-rated dementia screener, the AD8, to describe the rate of cognitive decline, examine associations of cognitive decline with age, educational level, sex designated at birth, and autistic traits, and document the psychometrics of a dementia screener in autistic adults. We found high rates of cognitive decline with 30% of the sample screening positive. The most common symptoms were declining interest in leisure activities, and increases in everyday problems with thinking, memory, and judgment. There was evidence that autistic individuals designated female at birth may be more vulnerable to cognitive decline than autistic individuals designated male at birth. Notably, reports of cognitive decline did not vary by age or educational level. Modestly elevated autistic traits were found in those screening positive versus negative for cognitive decline. Finally, the dementia screener showed good psychometrics, including convergent validity with an independent measure of current memory problems. These results could signal an emerging public health crisis in autistic adults as they age, and support the potential utility of self-report measures for early screening for cognitive decline in this population. En ligne : https://doi.org/10.1002/aur.2877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 The Sensory Observation Autism Rating Scale (SOAR): Developed using the PROMIS® framework / Katy L. UNWIN in Autism Research, 16-3 (March 2023)
[article]
Titre : The Sensory Observation Autism Rating Scale (SOAR): Developed using the PROMIS® framework Type de document : Texte imprimé et/ou numérique Auteurs : Katy L. UNWIN, Auteur ; Josephine BARBARO, Auteur ; Mirko ULJAREVIC, Auteur ; Azul HUSSAIN, Auteur ; Madison CHETCUTI, Auteur ; Alison. E. LANE, Auteur Article en page(s) : p.617-629 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autistic people experience the sensory world differently, impacting behavior. First-hand accounts and group-based research have found that sensory differences impact a range of things including family life, anxiety, participation, and daily living. Early sensory differences are widely reported to be associated with a cascade of developmental difference, suggesting that early autism diagnosis and sensory mapping could enable the provision of supports to facilitate flourishing. However, appropriate measurement tools are not available as all rely on proxy report or are observation measures which include limited modalities or domains and require the administration of stimuli. Therefore, following the gold-standard recommendations for measurement development outlined by the PROMIS® framework, we created the Sensory Observation Autism Rating scale (SOAR). We identified sensory behaviors across all primary domains and modalities through an extensive autism-sensory literature review and from focus groups with autism stakeholders. The initial item bank was then refined by an expert panel and through video coding five-minutes of free play from Autism Diagnostic Observation Schedule assessments of 105 age- and gender-matched autistic and developmentally delayed children (aged 13-36?months; 38 female). An additional 25% of the sample were double coded to investigate interrater reliability. Observational data and expert review supported the reduction of the item bank to 37 items. We propose that the refined SOAR has excellent face and ecological validity, along with interrater reliability (Intraclass correlation = 0.87-0.99). Following further data collection and refinement, SOAR has promise to fully characterize sensory behaviors in autistic children and indicate useful supports. En ligne : https://doi.org/10.1002/aur.2881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.617-629[article] The Sensory Observation Autism Rating Scale (SOAR): Developed using the PROMIS® framework [Texte imprimé et/ou numérique] / Katy L. UNWIN, Auteur ; Josephine BARBARO, Auteur ; Mirko ULJAREVIC, Auteur ; Azul HUSSAIN, Auteur ; Madison CHETCUTI, Auteur ; Alison. E. LANE, Auteur . - p.617-629.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.617-629
Index. décimale : PER Périodiques Résumé : Abstract Autistic people experience the sensory world differently, impacting behavior. First-hand accounts and group-based research have found that sensory differences impact a range of things including family life, anxiety, participation, and daily living. Early sensory differences are widely reported to be associated with a cascade of developmental difference, suggesting that early autism diagnosis and sensory mapping could enable the provision of supports to facilitate flourishing. However, appropriate measurement tools are not available as all rely on proxy report or are observation measures which include limited modalities or domains and require the administration of stimuli. Therefore, following the gold-standard recommendations for measurement development outlined by the PROMIS® framework, we created the Sensory Observation Autism Rating scale (SOAR). We identified sensory behaviors across all primary domains and modalities through an extensive autism-sensory literature review and from focus groups with autism stakeholders. The initial item bank was then refined by an expert panel and through video coding five-minutes of free play from Autism Diagnostic Observation Schedule assessments of 105 age- and gender-matched autistic and developmentally delayed children (aged 13-36?months; 38 female). An additional 25% of the sample were double coded to investigate interrater reliability. Observational data and expert review supported the reduction of the item bank to 37 items. We propose that the refined SOAR has excellent face and ecological validity, along with interrater reliability (Intraclass correlation = 0.87-0.99). Following further data collection and refinement, SOAR has promise to fully characterize sensory behaviors in autistic children and indicate useful supports. En ligne : https://doi.org/10.1002/aur.2881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Fine motor skill and expressive language in minimally verbal and verbal school-aged autistic children / Lindsay K. BUTLER in Autism Research, 16-3 (March 2023)
[article]
Titre : Fine motor skill and expressive language in minimally verbal and verbal school-aged autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay K. BUTLER, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.630-641 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Fine motor skill is associated with expressive language outcomes in infants who have an autistic sibling and in young autistic children. Fewer studies have focused on school-aged children even though around 80% have motor impairments and 30% remain minimally verbal (MV) into their school years. Moreover, expressive language is not a unitary construct, but it is made up of components such as speech production, structural language, and social-pragmatic language use. We used natural language sampling to investigate the relationship between fine motor and speech intelligibility, mean length of utterance and conversational turns in MV and verbal autistic children between the ages of 4 and 7 while controlling for age and adaptive behavior. Fine motor skill predicted speech production, measured by percent intelligible utterances. Fine motor skill and adaptive behavior predicted structural language, measured by mean length of utterance in morphemes. Adaptive behavior, but not fine motor skill, predicted social-pragmatic language use measured by number of conversational turns. Simple linear regressions by group corrected for multiple comparisons showed that fine motor skill predicted intelligibility for MV but not verbal children. Fine motor skill and adaptive behavior predicted mean length of utterance for both MV and verbal children. These findings suggest that future studies should explore whether MV children may benefit from interventions targeting fine motor along with speech and language into their school years. En ligne : https://doi.org/10.1002/aur.2883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.630-641[article] Fine motor skill and expressive language in minimally verbal and verbal school-aged autistic children [Texte imprimé et/ou numérique] / Lindsay K. BUTLER, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.630-641.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.630-641
Index. décimale : PER Périodiques Résumé : Abstract Fine motor skill is associated with expressive language outcomes in infants who have an autistic sibling and in young autistic children. Fewer studies have focused on school-aged children even though around 80% have motor impairments and 30% remain minimally verbal (MV) into their school years. Moreover, expressive language is not a unitary construct, but it is made up of components such as speech production, structural language, and social-pragmatic language use. We used natural language sampling to investigate the relationship between fine motor and speech intelligibility, mean length of utterance and conversational turns in MV and verbal autistic children between the ages of 4 and 7 while controlling for age and adaptive behavior. Fine motor skill predicted speech production, measured by percent intelligible utterances. Fine motor skill and adaptive behavior predicted structural language, measured by mean length of utterance in morphemes. Adaptive behavior, but not fine motor skill, predicted social-pragmatic language use measured by number of conversational turns. Simple linear regressions by group corrected for multiple comparisons showed that fine motor skill predicted intelligibility for MV but not verbal children. Fine motor skill and adaptive behavior predicted mean length of utterance for both MV and verbal children. These findings suggest that future studies should explore whether MV children may benefit from interventions targeting fine motor along with speech and language into their school years. En ligne : https://doi.org/10.1002/aur.2883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 The impact of autism spectrum disorder on parent employment: Results from the r-Kids study / Frances L. LYNCH in Autism Research, 16-3 (March 2023)
[article]
Titre : The impact of autism spectrum disorder on parent employment: Results from the r-Kids study Type de document : Texte imprimé et/ou numérique Auteurs : Frances L. LYNCH, Auteur ; Joanna E. BULKLEY, Auteur ; Alexandra VARGA, Auteur ; Phillip CRAWFORD, Auteur ; Lisa A. CROEN, Auteur ; Yihe G. DAIDA, Auteur ; Eric FOMBONNE, Auteur ; Brigit HATCH, Auteur ; Maria MASSOLO, Auteur ; John F. DICKERSON, Auteur Article en page(s) : p.642-652 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Parents of children with autism spectrum disorder (ASD) and other chronic health conditions often face exceptional caregiving demands that can lead to challenges related to maintaining and succeeding in employment. Detailed information on the specific ways in which these health conditions impact parent employment could aid in designing equitable, effective policies to support families. The r-Kids study used electronic health records to identify three groups of children: those with ASD, asthma, or neither condition (control), from several health care systems. We oversampled racial and ethnic minorities and matched the asthma and control groups to the age and sex distribution of the ASD group. Parents completed three online surveys over the course of a year to measure annual employment outcomes. Surveys included the Family Economic Impact Inventory (measuring employment impacts) and measures of quality of life and symptom severity. All materials were provided in English and Spanish. The study enrolled 1461 families (564 ASD, 468 asthma, 429 control). Youth were 3-16.5?years old and predominantly male (79%). The sample was diverse (43% non-Hispanic White; 35% non-Hispanic Asian, Black, Native Hawaiian, or Other; and 21% Hispanic ethnicity). Parents of children with ASD were significantly less likely to be employed than parents of youth with asthma and control combined (OR: 14.2, p 0.001), and were more likely to have other difficulties with employment and productivity while at work. Public and employer policies to help mitigate these impacts could aid families in managing care for youth with ASD. En ligne : https://doi.org/10.1002/aur.2882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.642-652[article] The impact of autism spectrum disorder on parent employment: Results from the r-Kids study [Texte imprimé et/ou numérique] / Frances L. LYNCH, Auteur ; Joanna E. BULKLEY, Auteur ; Alexandra VARGA, Auteur ; Phillip CRAWFORD, Auteur ; Lisa A. CROEN, Auteur ; Yihe G. DAIDA, Auteur ; Eric FOMBONNE, Auteur ; Brigit HATCH, Auteur ; Maria MASSOLO, Auteur ; John F. DICKERSON, Auteur . - p.642-652.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.642-652
Index. décimale : PER Périodiques Résumé : Abstract Parents of children with autism spectrum disorder (ASD) and other chronic health conditions often face exceptional caregiving demands that can lead to challenges related to maintaining and succeeding in employment. Detailed information on the specific ways in which these health conditions impact parent employment could aid in designing equitable, effective policies to support families. The r-Kids study used electronic health records to identify three groups of children: those with ASD, asthma, or neither condition (control), from several health care systems. We oversampled racial and ethnic minorities and matched the asthma and control groups to the age and sex distribution of the ASD group. Parents completed three online surveys over the course of a year to measure annual employment outcomes. Surveys included the Family Economic Impact Inventory (measuring employment impacts) and measures of quality of life and symptom severity. All materials were provided in English and Spanish. The study enrolled 1461 families (564 ASD, 468 asthma, 429 control). Youth were 3-16.5?years old and predominantly male (79%). The sample was diverse (43% non-Hispanic White; 35% non-Hispanic Asian, Black, Native Hawaiian, or Other; and 21% Hispanic ethnicity). Parents of children with ASD were significantly less likely to be employed than parents of youth with asthma and control combined (OR: 14.2, p 0.001), and were more likely to have other difficulties with employment and productivity while at work. Public and employer policies to help mitigate these impacts could aid families in managing care for youth with ASD. En ligne : https://doi.org/10.1002/aur.2882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Comparing autism phenotypes in children born extremely preterm and born at term / Robert M. JOSEPH in Autism Research, 16-3 (March 2023)
[article]
Titre : Comparing autism phenotypes in children born extremely preterm and born at term Type de document : Texte imprimé et/ou numérique Auteurs : Robert M. JOSEPH, Auteur ; Emily R. LAI, Auteur ; Somer BISHOP, Auteur ; Joe YI, Auteur ; Margaret L. BAUMAN, Auteur ; Jean A. FRAZIER, Auteur ; Hudson P. SANTOS JR, Auteur ; Laurie M. DOUGLAS, Auteur ; Karl K. C. KUBAN, Auteur ; Rebecca C. FRY, Auteur ; T. Michael O'SHEA, Auteur Article en page(s) : p.653-666 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Children born preterm are at increased risk for autism spectrum disorder (ASD). There is limited knowledge about whether ASD phenotypes in children born preterm differ from children born at term. The objective of this study was to compare ASD core symptoms and associated characteristics among extremely preterm (EP) and term-born children with ASD. EP participants (n = 59) from the Extremely Low Gestational Age Newborn Study who met diagnostic criteria for ASD at approximately 10?years of age were matched with term-born participants from the Simons Simplex Collection on age, sex, spoken language level, and nonverbal IQ. Core ASD symptomatology was evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Developmental milestones, anthropometrics, seizure disorder, and psychiatric symptoms were also investigated. The EP group had lower parent-reported symptom scores on ADI-R verbal communication, specifically stereotyped language, and restricted, repetitive behaviors. There were no between-group differences on ADI-R nonverbal communication and ADI-R reciprocal social interaction or with direct observation on the ADOS-2. The EP group was more likely to have delayed speech milestones and lower physical growth parameters. Results from female-only analyses were similar to those from whole-group analyses. In sum, behavioral presentation was similar between EP and IQ- and sex-matched term-born children assessed at age 10?years, with the exception of less severe retrospectively reported stereotyped behaviors, lower physical growth parameters, and increased delays in language milestones among EP-born children with ASD. En ligne : https://doi.org/10.1002/aur.2885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499
in Autism Research > 16-3 (March 2023) . - p.653-666[article] Comparing autism phenotypes in children born extremely preterm and born at term [Texte imprimé et/ou numérique] / Robert M. JOSEPH, Auteur ; Emily R. LAI, Auteur ; Somer BISHOP, Auteur ; Joe YI, Auteur ; Margaret L. BAUMAN, Auteur ; Jean A. FRAZIER, Auteur ; Hudson P. SANTOS JR, Auteur ; Laurie M. DOUGLAS, Auteur ; Karl K. C. KUBAN, Auteur ; Rebecca C. FRY, Auteur ; T. Michael O'SHEA, Auteur . - p.653-666.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.653-666
Index. décimale : PER Périodiques Résumé : Abstract Children born preterm are at increased risk for autism spectrum disorder (ASD). There is limited knowledge about whether ASD phenotypes in children born preterm differ from children born at term. The objective of this study was to compare ASD core symptoms and associated characteristics among extremely preterm (EP) and term-born children with ASD. EP participants (n = 59) from the Extremely Low Gestational Age Newborn Study who met diagnostic criteria for ASD at approximately 10?years of age were matched with term-born participants from the Simons Simplex Collection on age, sex, spoken language level, and nonverbal IQ. Core ASD symptomatology was evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Developmental milestones, anthropometrics, seizure disorder, and psychiatric symptoms were also investigated. The EP group had lower parent-reported symptom scores on ADI-R verbal communication, specifically stereotyped language, and restricted, repetitive behaviors. There were no between-group differences on ADI-R nonverbal communication and ADI-R reciprocal social interaction or with direct observation on the ADOS-2. The EP group was more likely to have delayed speech milestones and lower physical growth parameters. Results from female-only analyses were similar to those from whole-group analyses. In sum, behavioral presentation was similar between EP and IQ- and sex-matched term-born children assessed at age 10?years, with the exception of less severe retrospectively reported stereotyped behaviors, lower physical growth parameters, and increased delays in language milestones among EP-born children with ASD. En ligne : https://doi.org/10.1002/aur.2885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499