Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life / Fen ZHANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2223-2237 Titre : Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : Fen ZHANG, Auteur ; Floor MOERMAN, Auteur ; Haijing NIU, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.2223-2237 Langues : Anglais (eng) Mots-clés : Infant  Humans  Autism Spectrum Disorder  Neurodevelopmental Disorders  Brain/diagnostic imaging  Phenotype  autism spectrum disorder  brain network  functional connectivity  functional near-infrared spectroscopy  neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral features that appear early in life. Although studies have shown that atypical brain functional and structural connectivity are associated with these behavioral traits, the occurrence and initial alterations of brain networks have not been fully investigated. The current study aimed to map early brain network efficiency and information transferring in infants at elevated likelihood (EL) compared to infants at typical likelihood (TL) for ASD in the first year of life. This study used a resting-state functional near-infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5-month-old and 38 10-month-old infants. Modular organization and small-world properties were detected in both EL and TL infants at 5 and 10 months. In 5-month-old EL infants, local and nodal efficiency were significantly greater than age-matched TL infants, indicating overgrown local connections. Furthermore, we used a support vector machine (SVM) model to classify infants with or without EL based on the obtained global properties of the network, achieving an accuracy of 77.6%. These results suggest that infants with EL for ASD exhibit inefficiencies in the organization of brain networks during the first year of life. En ligne : http://dx.doi.org/10.1002/aur.2827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life [Texte imprimé et/ou numérique] / Fen ZHANG, Auteur ; Floor MOERMAN, Auteur ; Haijing NIU, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.2223-2237. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2223-2237 Mots-clés : Infant  Humans  Autism Spectrum Disorder  Neurodevelopmental Disorders  Brain/diagnostic imaging  Phenotype  autism spectrum disorder  brain network  functional connectivity  functional near-infrared spectroscopy  neurodevelopmental disorder Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral features that appear early in life. Although studies have shown that atypical brain functional and structural connectivity are associated with these behavioral traits, the occurrence and initial alterations of brain networks have not been fully investigated. The current study aimed to map early brain network efficiency and information transferring in infants at elevated likelihood (EL) compared to infants at typical likelihood (TL) for ASD in the first year of life. This study used a resting-state functional near-infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5-month-old and 38 10-month-old infants. Modular organization and small-world properties were detected in both EL and TL infants at 5 and 10 months. In 5-month-old EL infants, local and nodal efficiency were significantly greater than age-matched TL infants, indicating overgrown local connections. Furthermore, we used a support vector machine (SVM) model to classify infants with or without EL based on the obtained global properties of the network, achieving an accuracy of 77.6%. These results suggest that infants with EL for ASD exhibit inefficiencies in the organization of brain networks during the first year of life. En ligne : http://dx.doi.org/10.1002/aur.2827 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder / Floor MOERMAN in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1413-1430 Titre : Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Floor MOERMAN, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Sofie BOTERBERG, Auteur ; Julie VERMEIRSCH, Auteur ; Chloè BONTINCK, Auteur ; Eva BRUYNEEL, Auteur ; Marjolein MUÈS, Auteur ; Liedewij VERHAEGHE, Auteur ; Herbert ROEYERS, Auteur ; Team BABY STUDY, Auteur Article en page(s) : p.1413-1430 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Play of younger siblings of children with autism spectrum disorder (ASD) (siblings; n=44), very preterm children (preterms; n=44), and children at typical likelihood for ASD (n=36) was observed at 24 months. Children with ASD and atypical development engaged less in spontaneous (pre-)symbolic play than typically developing children. Total duration of spontaneous and elicited (pre-)symbolic play was associated with later ASD traits in siblings. However, no association between most play variables and ASD traits was found in preterms. This suggests possible different ASD-trajectories between siblings and preterms. Thus, spontaneous (pre-)symbolic play may be indicative of developmental challenges across several populations, and results highlight the need to move beyond studying only siblings in order to broaden our understanding of ASD. En ligne : https://doi.org/10.1007/s10803-021-05326-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Play in Relation to Autism Traits in Young Children at Elevated Likelihood for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Floor MOERMAN, Auteur ; Petra WARREYN, Auteur ; Ellen DEMURIE, Auteur ; Sofie BOTERBERG, Auteur ; Julie VERMEIRSCH, Auteur ; Chloè BONTINCK, Auteur ; Eva BRUYNEEL, Auteur ; Marjolein MUÈS, Auteur ; Liedewij VERHAEGHE, Auteur ; Herbert ROEYERS, Auteur ; Team BABY STUDY, Auteur . - p.1413-1430. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1413-1430 Index. décimale : PER Périodiques Résumé : Play of younger siblings of children with autism spectrum disorder (ASD) (siblings; n=44), very preterm children (preterms; n=44), and children at typical likelihood for ASD (n=36) was observed at 24 months. Children with ASD and atypical development engaged less in spontaneous (pre-)symbolic play than typically developing children. Total duration of spontaneous and elicited (pre-)symbolic play was associated with later ASD traits in siblings. However, no association between most play variables and ASD traits was found in preterms. This suggests possible different ASD-trajectories between siblings and preterms. Thus, spontaneous (pre-)symbolic play may be indicative of developmental challenges across several populations, and results highlight the need to move beyond studying only siblings in order to broaden our understanding of ASD. En ligne : https://doi.org/10.1007/s10803-021-05326-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

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