Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions / Seung Yun CHOI in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800 Titre : Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions Type de document : texte imprimé Auteurs : Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur Article en page(s) : p.788-800 Langues : Anglais (eng) Mots-clés : Early-life stress  ADHD  gene-brain-environment  vulnerability  individual differences Index. décimale : PER Périodiques Résumé : Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. En ligne : https://doi.org/10.1111/jcpp.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions [texte imprimé] / Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur . - p.788-800. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800 Mots-clés : Early-life stress  ADHD  gene-brain-environment  vulnerability  individual differences Index. décimale : PER Périodiques Résumé : Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. En ligne : https://doi.org/10.1111/jcpp.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? / Brennan H. BAKER in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.299-310 Titre : Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? Type de document : texte imprimé Auteurs : Brennan H. BAKER, Auteur ; Yoonjung Yoonie JOO, Auteur ; Junghoon PARK, Auteur ; Jiook CHA, Auteur ; Andrea A. BACCARELLI, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.299-310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. Methods The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined associations of maternal age with ADHD clinical range diagnoses based on the Child Behavior Checklist and NIH Toolbox Flanker Attention Scores using mixed logistic and linear regression models, respectively. We conducted confounding and causal mediation analyses using genotype array, demographic, socioeconomic, and prenatal environment data to investigate which genetic and environmental variables may explain the association between young maternal age and child ADHD. Results In crude models, each 10-year increase in maternal age was associated with 32% decreased odds of ADHD clinical range diagnosis (OR = 0.68; 95% CI [0.59, 0.78]) and 1.09-points increased NIH Flanker Attention Scores (ÃŽ2 = 1.09; 95% CI [0.76, 1.41]), indicating better child visual selective attention. However, adjustment for confounders weakened these associations. The strongest confounders were family income, caregiver education, and ADHD polygenic risk score for ADHD clinical range diagnoses, and family income, caregiver education, and race/ethnicity for NIH Flanker Attention Scores. Breastfeeding duration, prenatal alcohol exposure, and prenatal tobacco exposure were responsible for up to 18%, 6%, and 4% mediation, respectively. Conclusions Socioeconomic disadvantages were likely the primary explanation for the association of young maternal age with child ADHD, although genetics and modifiable environmental factors also played a role. Public policies aimed at reducing the burden of ADHD associated with young motherhood should target socioeconomic inequalities and support young pregnant women by advocating for reduced prenatal tobacco exposure and healthy breastfeeding practices after childbirth. En ligne : https://doi.org/10.1111/jcpp.13726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? [texte imprimé] / Brennan H. BAKER, Auteur ; Yoonjung Yoonie JOO, Auteur ; Junghoon PARK, Auteur ; Jiook CHA, Auteur ; Andrea A. BACCARELLI, Auteur ; Jonathan POSNER, Auteur . - p.299-310. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.299-310 Index. décimale : PER Périodiques Résumé : Background Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. Methods The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined associations of maternal age with ADHD clinical range diagnoses based on the Child Behavior Checklist and NIH Toolbox Flanker Attention Scores using mixed logistic and linear regression models, respectively. We conducted confounding and causal mediation analyses using genotype array, demographic, socioeconomic, and prenatal environment data to investigate which genetic and environmental variables may explain the association between young maternal age and child ADHD. Results In crude models, each 10-year increase in maternal age was associated with 32% decreased odds of ADHD clinical range diagnosis (OR = 0.68; 95% CI [0.59, 0.78]) and 1.09-points increased NIH Flanker Attention Scores (ÃŽ2 = 1.09; 95% CI [0.76, 1.41]), indicating better child visual selective attention. However, adjustment for confounders weakened these associations. The strongest confounders were family income, caregiver education, and ADHD polygenic risk score for ADHD clinical range diagnoses, and family income, caregiver education, and race/ethnicity for NIH Flanker Attention Scores. Breastfeeding duration, prenatal alcohol exposure, and prenatal tobacco exposure were responsible for up to 18%, 6%, and 4% mediation, respectively. Conclusions Socioeconomic disadvantages were likely the primary explanation for the association of young maternal age with child ADHD, although genetics and modifiable environmental factors also played a role. Public policies aimed at reducing the burden of ADHD associated with young motherhood should target socioeconomic inequalities and support young pregnant women by advocating for reduced prenatal tobacco exposure and healthy breastfeeding practices after childbirth. En ligne : https://doi.org/10.1111/jcpp.13726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

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