Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts / Amy Krain ROY in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.571-579 Titre : Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts Type de document : Texte imprimé et/ou numérique Auteurs : Amy Krain ROY, Auteur ; Randi BENNETT, Auteur ; Jonathan POSNER, Auteur ; Leslie HULVERSHORN, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Rachel G. KLEIN, Auteur Article en page(s) : p.571-579 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO. En ligne : http://dx.doi.org/10.1017/S0954579417001080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts [Texte imprimé et/ou numérique] / Amy Krain ROY, Auteur ; Randi BENNETT, Auteur ; Jonathan POSNER, Auteur ; Leslie HULVERSHORN, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Rachel G. KLEIN, Auteur . - p.571-579. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.571-579 Index. décimale : PER Périodiques Résumé : Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO. En ligne : http://dx.doi.org/10.1017/S0954579417001080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Titre : Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.1381-1391 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial [Texte imprimé et/ou numérique] / Yun WANG, Auteur ; Ellen KESSEL, Auteur ; Seonjoo LEE, Auteur ; Susie HONG, Auteur ; Elizabeth RAFFANELLO, Auteur ; Leslie A. HULVERSHORN, Auteur ; Amy MARGOLIS, Auteur ; Bradley S. PETERSON, Auteur ; Jonathan POSNER, Auteur . - p.1381-1391. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1381-1391 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Lisdexamfetamine Dimesylate/pharmacology/therapeutic use  Central Nervous System Stimulants/pharmacology  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Brain/diagnostic imaging  Magnetic Resonance Imaging  Adhd  Dynamic Functional MRI (fMRI)  Lisdexamfetamine  Striatum  Structural Equation Modeling  Thalamus Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics. METHODS: We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n=46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) were identified using static (time-averaged) and dynamic (time-varying) measures and then correlated with symptom improvement. Analyses were repeated in independent samples from the Adolescent Brain Cognitive Development study (n=103) and the ADHD-200 Consortium (n=213). RESULTS: In 49 participants (25 LDEX; 24 Placebo), LDEX increased static and decreased dynamic FC (DFC). However, only DFC was associated with the therapeutic effects of LDEX. Additionally, at baseline, DFC was elevated in unmedicated-ADHD participants relative to HCs. Independent samples yielded similar findings - ADHD was associated with increased DFC, and psychostimulants with reduced DFC. Static FC findings were inconsistent across samples. CONCLUSIONS: Changes in dynamic, but not static, FC were associated with the therapeutic effects of psychostimulants. While prior research has focused on static FC, DFC may offer a more reliable target for new ADHD interventions aimed at stabilizing network dynamics, though this needs confirmation with subsequent investigations. En ligne : http://dx.doi.org/10.1111/jcpp.13585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa / Jonathan POSNER ; Janet SCHEBENDACH ; Alexandra F. MURATORE ; Susie HONG ; Jessica OJEDA ; Elizabeth RAFANELLO ; Joanna E. STEINGLASS ; Karin FOERDE in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.378-389 Titre : Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan POSNER, Auteur ; Janet SCHEBENDACH, Auteur ; Alexandra F. MURATORE, Auteur ; Susie HONG, Auteur ; Jessica OJEDA, Auteur ; Elizabeth RAFANELLO, Auteur ; Joanna E. STEINGLASS, Auteur ; Karin FOERDE, Auteur Article en page(s) : p.378-389 Langues : Anglais (eng) Mots-clés : Anorexia nervosa  adolescence  neuroimaging  reward  caudate Index. décimale : PER Périodiques Résumé : Background Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN. Methods Healthy adolescents (HC, n?=?41) and adolescents with AN or atypical AN (atypAN, n?=?76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice-related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice-related activation and psychological assessments among the patient group. Results Adolescents with AN or atypAN selected fewer high-fat foods than HC (t?=??5.92, p? En ligne : https://doi.org/10.1111/jcpp.14066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa [Texte imprimé et/ou numérique] / Jonathan POSNER, Auteur ; Janet SCHEBENDACH, Auteur ; Alexandra F. MURATORE, Auteur ; Susie HONG, Auteur ; Jessica OJEDA, Auteur ; Elizabeth RAFANELLO, Auteur ; Joanna E. STEINGLASS, Auteur ; Karin FOERDE, Auteur . - p.378-389. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.378-389 Mots-clés : Anorexia nervosa  adolescence  neuroimaging  reward  caudate Index. décimale : PER Périodiques Résumé : Background Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN. Methods Healthy adolescents (HC, n?=?41) and adolescents with AN or atypical AN (atypAN, n?=?76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice-related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice-related activation and psychological assessments among the patient group. Results Adolescents with AN or atypAN selected fewer high-fat foods than HC (t?=??5.92, p? En ligne : https://doi.org/10.1111/jcpp.14066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Major depression, temperament, and social support as psychosocial mechanisms of the intergenerational transmission of parenting styles / Eyal ABRAHAM in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1997-2011 Titre : Major depression, temperament, and social support as psychosocial mechanisms of the intergenerational transmission of parenting styles Type de document : Texte imprimé et/ou numérique Auteurs : Eyal ABRAHAM, Auteur ; Allison M. LETKIEWICZ, Auteur ; Priya J. WICKRAMARATNE, Auteur ; Maya BUNYAN, Auteur ; Milenna T. VAN DIJK, Auteur ; Marc J. GAMEROFF, Auteur ; Jonathan POSNER, Auteur ; Ardesheer TALATI, Auteur ; Myrna M. WEISSMAN, Auteur Article en page(s) : p.1997-2011 Langues : Anglais (eng) Mots-clés : temperament  depression  social support  parenting  intergenerational transmission Index. décimale : PER Périodiques Résumé : In this three-generation longitudinal study of familial depression, we investigated the continuity of parenting styles, and major depressive disorder (MDD), temperament, and social support during childrearing as potential mechanisms. Each generation independently completed the Parental Bonding Instrument (PBI), measuring individuals’ experiences of care and overprotection received from parents during childhood. MDD was assessed prospectively, up to 38 years, using the semi-structured Schedule for Affective Disorders and Schizophrenia (SADS). Social support and temperament were assessed using the Social Adjustment Scale “ Self-Report (SAS-SR) and Dimensions of Temperament Scales “ Revised, respectively. We first assessed transmission of parenting styles in the generation 1 to generation 2 cycle (G1→G2), including 133 G1 and their 229 G2 children (367 pairs), and found continuity of both care and overprotection. G1 MDD accounted for the association between G1→G2 experiences of care, and G1 social support and temperament moderated the transmission of overprotection. The findings were largely similar when examining these psychosocial mechanisms in 111 G2 and their spouses (G2+S) and their 136 children (G3) (a total of 223 pairs). Finally, in a subsample of families with three successive generations (G1→G2→G3), G2 experiences of overprotection accounted for the association between G1→G3 experiences of overprotection. The results of this study highlight the roles of MDD, temperament, and social support in the intergenerational continuity of parenting, which should be considered in interventions to œbreak the cycle � of poor parenting practices across generations. En ligne : http://dx.doi.org/10.1017/S0954579421000420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Major depression, temperament, and social support as psychosocial mechanisms of the intergenerational transmission of parenting styles [Texte imprimé et/ou numérique] / Eyal ABRAHAM, Auteur ; Allison M. LETKIEWICZ, Auteur ; Priya J. WICKRAMARATNE, Auteur ; Maya BUNYAN, Auteur ; Milenna T. VAN DIJK, Auteur ; Marc J. GAMEROFF, Auteur ; Jonathan POSNER, Auteur ; Ardesheer TALATI, Auteur ; Myrna M. WEISSMAN, Auteur . - p.1997-2011. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1997-2011 Mots-clés : temperament  depression  social support  parenting  intergenerational transmission Index. décimale : PER Périodiques Résumé : In this three-generation longitudinal study of familial depression, we investigated the continuity of parenting styles, and major depressive disorder (MDD), temperament, and social support during childrearing as potential mechanisms. Each generation independently completed the Parental Bonding Instrument (PBI), measuring individuals’ experiences of care and overprotection received from parents during childhood. MDD was assessed prospectively, up to 38 years, using the semi-structured Schedule for Affective Disorders and Schizophrenia (SADS). Social support and temperament were assessed using the Social Adjustment Scale “ Self-Report (SAS-SR) and Dimensions of Temperament Scales “ Revised, respectively. We first assessed transmission of parenting styles in the generation 1 to generation 2 cycle (G1→G2), including 133 G1 and their 229 G2 children (367 pairs), and found continuity of both care and overprotection. G1 MDD accounted for the association between G1→G2 experiences of care, and G1 social support and temperament moderated the transmission of overprotection. The findings were largely similar when examining these psychosocial mechanisms in 111 G2 and their spouses (G2+S) and their 136 children (G3) (a total of 223 pairs). Finally, in a subsample of families with three successive generations (G1→G2→G3), G2 experiences of overprotection accounted for the association between G1→G3 experiences of overprotection. The results of this study highlight the roles of MDD, temperament, and social support in the intergenerational continuity of parenting, which should be considered in interventions to œbreak the cycle � of poor parenting practices across generations. En ligne : http://dx.doi.org/10.1017/S0954579421000420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? / Brennan H. BAKER in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.299-310 Titre : Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? Type de document : Texte imprimé et/ou numérique Auteurs : Brennan H. BAKER, Auteur ; Yoonjung Yoonie JOO, Auteur ; Junghoon PARK, Auteur ; Jiook CHA, Auteur ; Andrea A. BACCARELLI, Auteur ; Jonathan POSNER, Auteur Article en page(s) : p.299-310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. Methods The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined associations of maternal age with ADHD clinical range diagnoses based on the Child Behavior Checklist and NIH Toolbox Flanker Attention Scores using mixed logistic and linear regression models, respectively. We conducted confounding and causal mediation analyses using genotype array, demographic, socioeconomic, and prenatal environment data to investigate which genetic and environmental variables may explain the association between young maternal age and child ADHD. Results In crude models, each 10-year increase in maternal age was associated with 32% decreased odds of ADHD clinical range diagnosis (OR = 0.68; 95% CI [0.59, 0.78]) and 1.09-points increased NIH Flanker Attention Scores (Î2 = 1.09; 95% CI [0.76, 1.41]), indicating better child visual selective attention. However, adjustment for confounders weakened these associations. The strongest confounders were family income, caregiver education, and ADHD polygenic risk score for ADHD clinical range diagnoses, and family income, caregiver education, and race/ethnicity for NIH Flanker Attention Scores. Breastfeeding duration, prenatal alcohol exposure, and prenatal tobacco exposure were responsible for up to 18%, 6%, and 4% mediation, respectively. Conclusions Socioeconomic disadvantages were likely the primary explanation for the association of young maternal age with child ADHD, although genetics and modifiable environmental factors also played a role. Public policies aimed at reducing the burden of ADHD associated with young motherhood should target socioeconomic inequalities and support young pregnant women by advocating for reduced prenatal tobacco exposure and healthy breastfeeding practices after childbirth. En ligne : https://doi.org/10.1111/jcpp.13726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Maternal age at birth and child attention-deficit hyperactivity disorder: causal association or familial confounding? [Texte imprimé et/ou numérique] / Brennan H. BAKER, Auteur ; Yoonjung Yoonie JOO, Auteur ; Junghoon PARK, Auteur ; Jiook CHA, Auteur ; Andrea A. BACCARELLI, Auteur ; Jonathan POSNER, Auteur . - p.299-310. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.299-310 Index. décimale : PER Périodiques Résumé : Background Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. Methods The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined associations of maternal age with ADHD clinical range diagnoses based on the Child Behavior Checklist and NIH Toolbox Flanker Attention Scores using mixed logistic and linear regression models, respectively. We conducted confounding and causal mediation analyses using genotype array, demographic, socioeconomic, and prenatal environment data to investigate which genetic and environmental variables may explain the association between young maternal age and child ADHD. Results In crude models, each 10-year increase in maternal age was associated with 32% decreased odds of ADHD clinical range diagnosis (OR = 0.68; 95% CI [0.59, 0.78]) and 1.09-points increased NIH Flanker Attention Scores (Î2 = 1.09; 95% CI [0.76, 1.41]), indicating better child visual selective attention. However, adjustment for confounders weakened these associations. The strongest confounders were family income, caregiver education, and ADHD polygenic risk score for ADHD clinical range diagnoses, and family income, caregiver education, and race/ethnicity for NIH Flanker Attention Scores. Breastfeeding duration, prenatal alcohol exposure, and prenatal tobacco exposure were responsible for up to 18%, 6%, and 4% mediation, respectively. Conclusions Socioeconomic disadvantages were likely the primary explanation for the association of young maternal age with child ADHD, although genetics and modifiable environmental factors also played a role. Public policies aimed at reducing the burden of ADHD associated with young motherhood should target socioeconomic inequalities and support young pregnant women by advocating for reduced prenatal tobacco exposure and healthy breastfeeding practices after childbirth. En ligne : https://doi.org/10.1111/jcpp.13726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders / Angela TSENG in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

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