Neural activation to emotional faces in adolescents with autism spectrum disorders / Shih-Jen WENG in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Titre : Neural activation to emotional faces in adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur Année de publication : 2011 Article en page(s) : p.296-305 Langues : Anglais (eng) Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Neural activation to emotional faces in adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur . - 2011 . - p.296-305. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth / Kate DIMOND FITZGERALD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.986-994 Titre : Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth Type de document : Texte imprimé et/ou numérique Auteurs : Kate DIMOND FITZGERALD, Auteur ; Christopher D. ZBROZEK, Auteur ; Robert C. WELSH, Auteur ; Jennifer C. BRITTON, Auteur ; Israel LIBERZON, Auteur ; Stephan F. TAYLOR, Auteur Année de publication : 2008 Article en page(s) : p.986-994 Langues : Anglais (eng) Mots-clés : Antisaccade response-inhibition error-processing anterior-cingulate developmental-neuroimaging Index. décimale : PER Périodiques Résumé : Background: Recent neuroimaging work suggests that inhibitory and error processing in healthy adults share overlapping, but functionally distinct neural circuitries within the posterior medial frontal cortex (pMFC); however, it remains unknown whether the pMFC is differentially engaged by response inhibition compared to error commission in the developing brain. Developmental neuroimaging studies of response inhibition have found pMFC activation, but the possible contribution of error-related activation during inhibitory processing has not been well studied in youth. Method: To examine the processing of correct response inhibition compared to errors in the developing brain, we performed functional magnetic resonance imaging scans in 11 healthy subjects, ages 8–14 years, during an antisaccade task while performance was monitored. Results: Successful antisaccades activated the pre-supplementary motor area. In contrast, errors on the antisaccade task activated the dorsal anterior cingulate cortex. Conclusion: The findings suggest the functional sub-specialization of inhibitory and error processing within the pMFC in this pilot sample of children and adolescents. Future neuroimaging studies of developing inhibitory control should examine both between correct and error trials. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01906.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth [Texte imprimé et/ou numérique] / Kate DIMOND FITZGERALD, Auteur ; Christopher D. ZBROZEK, Auteur ; Robert C. WELSH, Auteur ; Jennifer C. BRITTON, Auteur ; Israel LIBERZON, Auteur ; Stephan F. TAYLOR, Auteur . - 2008 . - p.986-994. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.986-994 Mots-clés : Antisaccade response-inhibition error-processing anterior-cingulate developmental-neuroimaging Index. décimale : PER Périodiques Résumé : Background: Recent neuroimaging work suggests that inhibitory and error processing in healthy adults share overlapping, but functionally distinct neural circuitries within the posterior medial frontal cortex (pMFC); however, it remains unknown whether the pMFC is differentially engaged by response inhibition compared to error commission in the developing brain. Developmental neuroimaging studies of response inhibition have found pMFC activation, but the possible contribution of error-related activation during inhibitory processing has not been well studied in youth. Method: To examine the processing of correct response inhibition compared to errors in the developing brain, we performed functional magnetic resonance imaging scans in 11 healthy subjects, ages 8–14 years, during an antisaccade task while performance was monitored. Results: Successful antisaccades activated the pre-supplementary motor area. In contrast, errors on the antisaccade task activated the dorsal anterior cingulate cortex. Conclusion: The findings suggest the functional sub-specialization of inhibitory and error processing within the pMFC in this pilot sample of children and adolescents. Future neuroimaging studies of developing inhibitory control should examine both between correct and error trials. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01906.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

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