Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition / Tomer SHECHNER in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.179-189 Titre : Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur Article en page(s) : p.179-189 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition [Texte imprimé et/ou numérique] / Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur . - p.179-189. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.179-189 Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Isolating neural components of threat bias in pediatric anxiety / Jennifer C. BRITTON in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686 Titre : Isolating neural components of threat bias in pediatric anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur Année de publication : 2012 Article en page(s) : p.678–686 Langues : Anglais (eng) Mots-clés : magnetoencephalography  ventrolateral prefrontal cortex  attention Index. décimale : PER Périodiques Résumé : Background:  Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question. Methods:  Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes. Results:  Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues. Conclusions:  In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157 [article] Isolating neural components of threat bias in pediatric anxiety [Texte imprimé et/ou numérique] / Jennifer C. BRITTON, Auteur ; Yair BAR-HAIM, Auteur ; Frederick W. CARVER, Auteur ; Tom HOLROYD, Auteur ; Maxine A. NORCROSS, Auteur ; Allison DETLOFF, Auteur ; Ellen LEIBENLUFT, Auteur ; Monique ERNST, Auteur ; Daniel Samuel PINE, Auteur . - 2012 . - p.678–686. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.678–686 Mots-clés : magnetoencephalography  ventrolateral prefrontal cortex  attention Index. décimale : PER Périodiques Résumé : Background:  Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location previously occupied by a threat (i.e., congruent) faster than when opposite threats (i.e., incongruent). In pediatric anxiety disorders, dot-probe paradigms detect abnormal attention biases toward threat and abnormal ventrolateral prefrontal cortex (vlPFC) function. However, it remains unclear if this aberrant vlPFC activation occurs while subjects process threats (e.g., angry faces) or, alternatively, while they process and respond to probes. This magnetoencephalography (MEG) study was designed to answer this question. Methods:  Adolescents with either generalized anxiety disorder (GAD, n = 17) or no psychiatric diagnosis (n = 25) performed a dot-probe task involving angry and neutral faces while MEG data were collected. Synthetic Aperture Magnetometry (SAM) beamformer technique was used to determine whether there were group differences in power ratios while subjects processed threats (i.e., angry vs. neutral faces) or when subjects responded to incongruent versus. congruent probes. Results:  Group differences in vlPFC activation during the response period emerged with a 1–30 Hz frequency band. No group differences in vlPFC activation were detected in response to angry-face cues. Conclusions:  In the dot-probe task, anxiety-related perturbations in vlPFC activation reflect abnormal attention control when responding to behaviorally relevant probes, but not to angry faces. Given that motor responses to these probes are used to calculate threat bias, this study provides insight into the pathophysiology reflected in this commonly used marker of anxiety. In addition, this finding may inform the development of novel anxiety-disorder treatments targeting the vlPFC to enhance attention control to task-relevant demands. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02503.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157

Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder / Bryce DIRKS in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1501-1515 Titre : Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bryce DIRKS, Auteur ; Celia ROMERO, Auteur ; Willa VOORHIES, Auteur ; Lauren KUPIS, Auteur ; Jason S. NOMI, Auteur ; Dina R. DAJANI, Auteur ; Paola ODRIOZOLA, Auteur ; Catherine A. BURROWS, Auteur ; Amy L. BEAUMONT, Auteur ; Sandra M. CARDONA, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.1501-1515 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While much progress has been made toward understanding the neurobiology of social and communication deficits associated with autism spectrum disorder (ASD), less is known regarding the neurobiological basis of restricted and repetitive behaviors (RRBs) central to the ASD diagnosis. Symptom severity for RRBs in ASD is associated with cognitive inflexibility. Thus, understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat this understudied yet pervasive symptom. Here we used a set-shifting paradigm adopted from the developmental cognitive neuroscience literature involving flexible switching between stimulus categories to examine task performance and neural responses in children with ASD. Behaviorally, we found little evidence for group differences in performance on the set-shifting task. Compared with typically developing children, children with ASD exhibited greater activation of the parahippocampal gyrus during performance on trials requiring switching. These findings suggest that children with ASD may need to recruit memory-based neural systems to a greater degree when learning to flexibly associate stimuli with responses. Lay Summary Children with autism often struggle to behave in a flexible way when faced with unexpected challenges. We examined brain responses during a task thought to involve flexible thinking and found that compared with typically developing children, those with autism relied more on brain areas involved in learning and memory to complete the task. This study helps us to understand what types of cognitive tasks are best suited for exploring the neural basis of cognitive flexibility in children with autism. Autism Res 2020, 13: 1501–1515. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Bryce DIRKS, Auteur ; Celia ROMERO, Auteur ; Willa VOORHIES, Auteur ; Lauren KUPIS, Auteur ; Jason S. NOMI, Auteur ; Dina R. DAJANI, Auteur ; Paola ODRIOZOLA, Auteur ; Catherine A. BURROWS, Auteur ; Amy L. BEAUMONT, Auteur ; Sandra M. CARDONA, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Lucina Q. UDDIN, Auteur . - p.1501-1515. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1501-1515 Index. décimale : PER Périodiques Résumé : While much progress has been made toward understanding the neurobiology of social and communication deficits associated with autism spectrum disorder (ASD), less is known regarding the neurobiological basis of restricted and repetitive behaviors (RRBs) central to the ASD diagnosis. Symptom severity for RRBs in ASD is associated with cognitive inflexibility. Thus, understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat this understudied yet pervasive symptom. Here we used a set-shifting paradigm adopted from the developmental cognitive neuroscience literature involving flexible switching between stimulus categories to examine task performance and neural responses in children with ASD. Behaviorally, we found little evidence for group differences in performance on the set-shifting task. Compared with typically developing children, children with ASD exhibited greater activation of the parahippocampal gyrus during performance on trials requiring switching. These findings suggest that children with ASD may need to recruit memory-based neural systems to a greater degree when learning to flexibly associate stimuli with responses. Lay Summary Children with autism often struggle to behave in a flexible way when faced with unexpected challenges. We examined brain responses during a task thought to involve flexible thinking and found that compared with typically developing children, those with autism relied more on brain areas involved in learning and memory to complete the task. This study helps us to understand what types of cognitive tasks are best suited for exploring the neural basis of cognitive flexibility in children with autism. Autism Res 2020, 13: 1501–1515. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Objective measurement of head movement differences in children with and without autism spectrum disorder / K. B. MARTIN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 14p. Titre : Objective measurement of head movement differences in children with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. B. MARTIN, Auteur ; Z. HAMMAL, Auteur ; G. REN, Auteur ; Jeffrey F. COHN, Auteur ; J. CASSELL, Auteur ; M. OGIHARA, Auteur ; Jennifer C. BRITTON, Auteur ; A. GUTIERREZ, Auteur ; D. S. MESSINGER, Auteur Article en page(s) : 14p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Head movement  Motor movement  Social processing Index. décimale : PER Périodiques Résumé : Background: Deficits in motor movement in children with autism spectrum disorder (ASD) have typically been characterized qualitatively by human observers. Although clinicians have noted the importance of atypical head positioning (e.g. social peering and repetitive head banging) when diagnosing children with ASD, a quantitative understanding of head movement in ASD is lacking. Here, we conduct a quantitative comparison of head movement dynamics in children with and without ASD using automated, person-independent computer-vision based head tracking (Zface). Because children with ASD often exhibit preferential attention to nonsocial versus social stimuli, we investigated whether children with and without ASD differed in their head movement dynamics depending on stimulus sociality. Methods: The current study examined differences in head movement dynamics in children with (n = 21) and without ASD (n = 21). Children were video-recorded while watching a 16-min video of social and nonsocial stimuli. Three dimensions of rigid head movement-pitch (head nods), yaw (head turns), and roll (lateral head inclinations)-were tracked using Zface. The root mean square of pitch, yaw, and roll was calculated to index the magnitude of head angular displacement (quantity of head movement) and angular velocity (speed). Results: Compared with children without ASD, children with ASD exhibited greater yaw displacement, indicating greater head turning, and greater velocity of yaw and roll, indicating faster head turning and inclination. Follow-up analyses indicated that differences in head movement dynamics were specific to the social rather than the nonsocial stimulus condition. Conclusions: Head movement dynamics (displacement and velocity) were greater in children with ASD than in children without ASD, providing a quantitative foundation for previous clinical reports. Head movement differences were evident in lateral (yaw and roll) but not vertical (pitch) movement and were specific to a social rather than nonsocial condition. When presented with social stimuli, children with ASD had higher levels of head movement and moved their heads more quickly than children without ASD. Children with ASD may use head movement to modulate their perception of social scenes. En ligne : http://dx.doi.org/10.1186/s13229-018-0198-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Objective measurement of head movement differences in children with and without autism spectrum disorder [Texte imprimé et/ou numérique] / K. B. MARTIN, Auteur ; Z. HAMMAL, Auteur ; G. REN, Auteur ; Jeffrey F. COHN, Auteur ; J. CASSELL, Auteur ; M. OGIHARA, Auteur ; Jennifer C. BRITTON, Auteur ; A. GUTIERREZ, Auteur ; D. S. MESSINGER, Auteur . - 14p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 14p. Mots-clés : Autism spectrum disorder  Head movement  Motor movement  Social processing Index. décimale : PER Périodiques Résumé : Background: Deficits in motor movement in children with autism spectrum disorder (ASD) have typically been characterized qualitatively by human observers. Although clinicians have noted the importance of atypical head positioning (e.g. social peering and repetitive head banging) when diagnosing children with ASD, a quantitative understanding of head movement in ASD is lacking. Here, we conduct a quantitative comparison of head movement dynamics in children with and without ASD using automated, person-independent computer-vision based head tracking (Zface). Because children with ASD often exhibit preferential attention to nonsocial versus social stimuli, we investigated whether children with and without ASD differed in their head movement dynamics depending on stimulus sociality. Methods: The current study examined differences in head movement dynamics in children with (n = 21) and without ASD (n = 21). Children were video-recorded while watching a 16-min video of social and nonsocial stimuli. Three dimensions of rigid head movement-pitch (head nods), yaw (head turns), and roll (lateral head inclinations)-were tracked using Zface. The root mean square of pitch, yaw, and roll was calculated to index the magnitude of head angular displacement (quantity of head movement) and angular velocity (speed). Results: Compared with children without ASD, children with ASD exhibited greater yaw displacement, indicating greater head turning, and greater velocity of yaw and roll, indicating faster head turning and inclination. Follow-up analyses indicated that differences in head movement dynamics were specific to the social rather than the nonsocial stimulus condition. Conclusions: Head movement dynamics (displacement and velocity) were greater in children with ASD than in children without ASD, providing a quantitative foundation for previous clinical reports. Head movement differences were evident in lateral (yaw and roll) but not vertical (pitch) movement and were specific to a social rather than nonsocial condition. When presented with social stimuli, children with ASD had higher levels of head movement and moved their heads more quickly than children without ASD. Children with ASD may use head movement to modulate their perception of social scenes. En ligne : http://dx.doi.org/10.1186/s13229-018-0198-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function / Adriana C. BAEZ in Journal of Autism and Developmental Disorders, 50-3 (March 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.707-718 Titre : Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function Type de document : Texte imprimé et/ou numérique Auteurs : Adriana C. BAEZ, Auteur ; Dina R. DAJANI, Auteur ; Willa VOORHIES, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Maria M. LLABRE, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.707-718 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior Rating Inventory of Executive Function  Dimensional  Latent profile analysis Index. décimale : PER Périodiques Résumé : Executive function (EF), the set of cognitive processes that govern goal-directed behavior, varies within developmental samples and clinical populations. Here, we perform a conceptual replication of prior work (Dajani et al. in Sci Rep 6:36566, 2016) in an independent sample of typically developing children (n = 183) and children with autism spectrum disorder (n = 104). Consistent with previous work, the latent profile analysis of parent-report EF measures provided evidence for three EF classes, which exhibited differential proportions of diagnostic groups. Additionally, children in the impaired EF group exhibited greater levels of social impairment. These results highlight the heterogeneity of EF ability among clinical and non-clinical populations and the link between EF and social abilities. En ligne : http://dx.doi.org/10.1007/s10803-019-04290-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=419 [article] Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function [Texte imprimé et/ou numérique] / Adriana C. BAEZ, Auteur ; Dina R. DAJANI, Auteur ; Willa VOORHIES, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Maria M. LLABRE, Auteur ; Lucina Q. UDDIN, Auteur . - p.707-718. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.707-718 Mots-clés : Autism spectrum disorder  Behavior Rating Inventory of Executive Function  Dimensional  Latent profile analysis Index. décimale : PER Périodiques Résumé : Executive function (EF), the set of cognitive processes that govern goal-directed behavior, varies within developmental samples and clinical populations. Here, we perform a conceptual replication of prior work (Dajani et al. in Sci Rep 6:36566, 2016) in an independent sample of typically developing children (n = 183) and children with autism spectrum disorder (n = 104). Consistent with previous work, the latent profile analysis of parent-report EF measures provided evidence for three EF classes, which exhibited differential proportions of diagnostic groups. Additionally, children in the impaired EF group exhibited greater levels of social impairment. These results highlight the heterogeneity of EF ability among clinical and non-clinical populations and the link between EF and social abilities. En ligne : http://dx.doi.org/10.1007/s10803-019-04290-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=419

Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth / Kate DIMOND FITZGERALD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

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