Association between depression diagnosis and educational attainment trajectories: an historical cohort study using linked data / Alice WICKERSHAM in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1617-1627 Titre : Association between depression diagnosis and educational attainment trajectories: an historical cohort study using linked data Type de document : texte imprimé Auteurs : Alice WICKERSHAM, Auteur ; Ben CARTER, Auteur ; Amelia JEWELL, Auteur ; Tamsin FORD, Auteur ; Robert STEWART, Auteur ; Johnny DOWNS, Auteur Article en page(s) : p.1617-1627 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Depression symptoms are thought to be associated with lower educational attainment, but patterns of change in attainment among those who receive a clinical diagnosis of depression at any point during childhood and adolescence remain unclear. Methods We conducted a secondary analysis of an existing data linkage between a national educational dataset (National Pupil Database) and pseudonymised electronic health records (Clinical Record Interactive Search) from a large mental healthcare provider in London, United Kingdom (2007 to 2013). A cohort of 222,027 pupils were included. We used Growth Mixture Modelling (GMM) and stakeholder input to estimate trajectories of standardised educational attainment over School Years 2, 6 and 11. Multinomial logistic regression analyses were then used to investigate the association between resulting educational attainment trajectory membership (outcome) and depression diagnosis any time before age 18 (exposure). Results A five-trajectory GMM solution for attainment was derived: (1) average/high-stable, (2) average-modest declining, (3) average-steep declining, (4) low-improving and (5) low-stable. After adjusting for clinical and sociodemographic covariates, having a depression diagnosis before age 18 was associated with occupying the average-modest declining trajectory (RRR = 2.80, 95% CI 2.36-3.32, p<.001) or the average-steep declining trajectory (RRR = 3.54, 95% CI 3.10-4.04, p<.001), as compared to the average/high-stable trajectory. Conclusions Receiving a diagnosis of depression before age 18 was associated with a relative decline in attainment throughout school. While these findings cannot support a causal direction, they nonetheless suggest a need for timely mental health and educational support among pupils struggling with depression. En ligne : https://doi.org/10.1111/jcpp.13759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Association between depression diagnosis and educational attainment trajectories: an historical cohort study using linked data [texte imprimé] / Alice WICKERSHAM, Auteur ; Ben CARTER, Auteur ; Amelia JEWELL, Auteur ; Tamsin FORD, Auteur ; Robert STEWART, Auteur ; Johnny DOWNS, Auteur . - p.1617-1627. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1617-1627 Index. décimale : PER Périodiques Résumé : Background Depression symptoms are thought to be associated with lower educational attainment, but patterns of change in attainment among those who receive a clinical diagnosis of depression at any point during childhood and adolescence remain unclear. Methods We conducted a secondary analysis of an existing data linkage between a national educational dataset (National Pupil Database) and pseudonymised electronic health records (Clinical Record Interactive Search) from a large mental healthcare provider in London, United Kingdom (2007 to 2013). A cohort of 222,027 pupils were included. We used Growth Mixture Modelling (GMM) and stakeholder input to estimate trajectories of standardised educational attainment over School Years 2, 6 and 11. Multinomial logistic regression analyses were then used to investigate the association between resulting educational attainment trajectory membership (outcome) and depression diagnosis any time before age 18 (exposure). Results A five-trajectory GMM solution for attainment was derived: (1) average/high-stable, (2) average-modest declining, (3) average-steep declining, (4) low-improving and (5) low-stable. After adjusting for clinical and sociodemographic covariates, having a depression diagnosis before age 18 was associated with occupying the average-modest declining trajectory (RRR = 2.80, 95% CI 2.36-3.32, p<.001) or the average-steep declining trajectory (RRR = 3.54, 95% CI 3.10-4.04, p<.001), as compared to the average/high-stable trajectory. Conclusions Receiving a diagnosis of depression before age 18 was associated with a relative decline in attainment throughout school. While these findings cannot support a causal direction, they nonetheless suggest a need for timely mental health and educational support among pupils struggling with depression. En ligne : https://doi.org/10.1111/jcpp.13759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Examining the association between placental malperfusion assessed by histopathological examination and child and adolescent neurodevelopment: a systematic review / Noha IBRAHIM in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1606-1620 Titre : Examining the association between placental malperfusion assessed by histopathological examination and child and adolescent neurodevelopment: a systematic review Type de document : texte imprimé Auteurs : Noha IBRAHIM, Auteur ; Sydni A. WEISSGOLD, Auteur ; Lucy BRINK, Auteur ; Ibtihal MAHGOUB, Auteur ; Ben CARTER, Auteur ; Vaheshta SETHNA, Auteur ; Hein ODENDAAL, Auteur Article en page(s) : p.1606-1620 Langues : Anglais (eng) Mots-clés : Placental vascular malperfusion  placental vascular under-perfusion  placental histopathology  neurodevelopmental disorders  systematic review Index. décimale : PER Périodiques Résumé : Background Placental malperfusion, categorised into maternal vascular malperfusion (MVM) and foetal vascular malperfusion (FVM), is a main placental pathology known to affect placental functioning and offspring outcomes. The aim of this review is to evaluate the association between exposure to placental malperfusion and offspring neurodevelopment from birth to 18 years of age. Methods Following the registered protocol on Prospero, Medline, Cochrane, CINHAL, Embase and PsycINFO databases were searched systematically from inception to 01/11/2023. Included were publications examining exposure to placental malperfusion detected on histopathological examination and clinically measured neurodevelopmental outcomes. Publications on multi-pregnancies or animals, exposure to malformations, surgical or medical interventions, review and opinion articles, or those not translated to English, were excluded. Grey literature search and forward and backward citation chaining were performed. The Joanna Briggs Institute's checklists were used for quality assessment. Three studies were pooled using percentages of adjusted associations. Results Nine observational studies fulfilled the eligibility criteria. The included neurodevelopmental outcomes were assessed from 5 days to 8 years when age of assessment is reported. Four publications showed an association between exposure to MVM and poor neurodevelopment at 10 40 months and 8 years, however, no association was observed when examining preterm infants up to 24 months. Conversely, in the six studies examining exposure to FVM, FVM association with neurodevelopmental disorders was reported in two studies looking at preterm infants assessed at 24 months and 8 years and better neurodevelopmental scores in other two studies at 10 40 months. Conclusions The pattern of association between MVM and FVM with neurodevelopmental outcomes varied among the included studies. Clinical and methodological heterogeneities and poor reporting of relevant populations' characteristics hindered full understanding of the results. Methodologically rigorous research is required to help utilise histopathological findings of placental malperfusion in predicting offspring's neurodevelopmental outcomes. En ligne : https://doi.org/10.1111/jcpp.14152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Examining the association between placental malperfusion assessed by histopathological examination and child and adolescent neurodevelopment: a systematic review [texte imprimé] / Noha IBRAHIM, Auteur ; Sydni A. WEISSGOLD, Auteur ; Lucy BRINK, Auteur ; Ibtihal MAHGOUB, Auteur ; Ben CARTER, Auteur ; Vaheshta SETHNA, Auteur ; Hein ODENDAAL, Auteur . - p.1606-1620. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1606-1620 Mots-clés : Placental vascular malperfusion  placental vascular under-perfusion  placental histopathology  neurodevelopmental disorders  systematic review Index. décimale : PER Périodiques Résumé : Background Placental malperfusion, categorised into maternal vascular malperfusion (MVM) and foetal vascular malperfusion (FVM), is a main placental pathology known to affect placental functioning and offspring outcomes. The aim of this review is to evaluate the association between exposure to placental malperfusion and offspring neurodevelopment from birth to 18 years of age. Methods Following the registered protocol on Prospero, Medline, Cochrane, CINHAL, Embase and PsycINFO databases were searched systematically from inception to 01/11/2023. Included were publications examining exposure to placental malperfusion detected on histopathological examination and clinically measured neurodevelopmental outcomes. Publications on multi-pregnancies or animals, exposure to malformations, surgical or medical interventions, review and opinion articles, or those not translated to English, were excluded. Grey literature search and forward and backward citation chaining were performed. The Joanna Briggs Institute's checklists were used for quality assessment. Three studies were pooled using percentages of adjusted associations. Results Nine observational studies fulfilled the eligibility criteria. The included neurodevelopmental outcomes were assessed from 5 days to 8 years when age of assessment is reported. Four publications showed an association between exposure to MVM and poor neurodevelopment at 10 40 months and 8 years, however, no association was observed when examining preterm infants up to 24 months. Conversely, in the six studies examining exposure to FVM, FVM association with neurodevelopmental disorders was reported in two studies looking at preterm infants assessed at 24 months and 8 years and better neurodevelopmental scores in other two studies at 10 40 months. Conclusions The pattern of association between MVM and FVM with neurodevelopmental outcomes varied among the included studies. Clinical and methodological heterogeneities and poor reporting of relevant populations' characteristics hindered full understanding of the results. Methodologically rigorous research is required to help utilise histopathological findings of placental malperfusion in predicting offspring's neurodevelopmental outcomes. En ligne : https://doi.org/10.1111/jcpp.14152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People / Bethany OAKLEY in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70153 Titre : Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People Type de document : texte imprimé Auteurs : Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur Article en page(s) : p.e70153 Langues : Anglais (eng) Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People [texte imprimé] / Bethany OAKLEY, Auteur ; Charlotte A. BOATMAN, Auteur ; Saffron BALDOZA, Auteur ; Amy HEARN, Auteur ; Colin LARKWORTHY, Auteur ; Rachel KENT, Auteur ; Ann OZSIVADJIAN, Auteur ; Sophie DOSWELL, Auteur ; Antonia DITTNER, Auteur ; Amanda ROESTORF, Auteur ; Dhara RAWAL, Auteur ; Ben CARTER, Auteur ; Emily SIMONOFF, Auteur ; Group THE MOLEHILL MOUNTAIN ADVISORY, Auteur . - p.e70153. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70153 Mots-clés : anxiety  autism  CBT  digital tools  intervention  mental health  mHealth Index. décimale : PER Périodiques Résumé : ABSTRACT At least 50% of autistic people experience clinically relevant anxiety symptoms. However, reasons for elevated rates of anxiety in autism remain poorly understood and there is a high unmet need for novel and adapted therapies for anxiety that are accessible to autistic people. This study aimed to establish the feasibility of a novel app-based anxiety management tool (?Molehill Mountain?) that has been developed with, and adapted for, autistic people. A single-centre, single-arm feasibility study design was employed, whereby autistic people (≥?16?years) with mild-to-severe symptoms of anxiety were recruited to a 13-week intervention period (King's College London, UK; clinicaltrials.gov identifier NCT05302167). Of 123 prospective participants screened, 100 (81%) participants aged 16?74?years (n?=?69 female) were enrolled within approximately 15 months. n?=?76 (76%) completed an anxiety measure at ~15?weeks (Generalized Anxiety Disorder?7 Item Scale; GAD-7). Most adhered to the full intervention duration: 65% (n?=?47), with most using the app weekly (1?6?days per week; 58%). 73% of participants agreed that they found the app easy to use overall and that an app is a good format for offering anxiety support to autistic people. There was a significant reduction in self-reported anxiety symptom severity with mean difference 2.88 (95% CI 1.88, 3.89; p? En ligne : https://doi.org/10.1002/aur.70153 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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