Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism / Greg PASCO ; Jannath Begum ALI ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2184-2197 Titre : Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism Type de document : Texte imprimé et/ou numérique Auteurs : Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2184-2197 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism [Texte imprimé et/ou numérique] / Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur . - p.2184-2197. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2184-2197 Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36?months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36?months and autism trait scores at 36?months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36?months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Mid-childhood autism sibling recurrence in infants with a family history of autism / Rowan ARTHUR ; Greg PASCO ; Elizabeth SHEPHARD ; Bosiljka MILOSAVLJEVIC ; Jannath Begum ALI ; Andrew PICKLES ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN ; The BASIS/STAARS TEAM in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1501-1514 Titre : Mid-childhood autism sibling recurrence in infants with a family history of autism Type de document : Texte imprimé et/ou numérique Auteurs : Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur Article en page(s) : p.1501-1514 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Mid-childhood autism sibling recurrence in infants with a family history of autism [Texte imprimé et/ou numérique] / Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur . - p.1501-1514. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1501-1514 Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

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