Consanguinity as a Risk Factor for Autism / Mohammed ALDOSARI ; Iman GHAZAL ; Hawraa AL-SHAMMARI ; Saba ELHAG ; I. Richard THOMPSON ; Jennifer BRUDER ; Hibah SHAATH ; Fatema AL-FARAJ ; Mohamed TOLEFAT ; Assal NASIR ; Eric FOMBONNE in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1945-1952 Titre : Consanguinity as a Risk Factor for Autism Type de document : texte imprimé Auteurs : Mohammed ALDOSARI, Auteur ; Iman GHAZAL, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba ELHAG, Auteur ; I. Richard THOMPSON, Auteur ; Jennifer BRUDER, Auteur ; Hibah SHAATH, Auteur ; Fatema AL-FARAJ, Auteur ; Mohamed TOLEFAT, Auteur ; Assal NASIR, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : p.1945-1952 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = .836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: .751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. En ligne : https://doi.org/10.1007/s10803-023-06137-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Consanguinity as a Risk Factor for Autism [texte imprimé] / Mohammed ALDOSARI, Auteur ; Iman GHAZAL, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba ELHAG, Auteur ; I. Richard THOMPSON, Auteur ; Jennifer BRUDER, Auteur ; Hibah SHAATH, Auteur ; Fatema AL-FARAJ, Auteur ; Mohamed TOLEFAT, Auteur ; Assal NASIR, Auteur ; Eric FOMBONNE, Auteur . - p.1945-1952. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1945-1952 Index. décimale : PER Périodiques Résumé : Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = .836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: .751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. En ligne : https://doi.org/10.1007/s10803-023-06137-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Development and validation of an Arabic language eye-tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar / Iman GHAZAL ; I. Richard THOMPSON ; Eric W. KLINGEMIER ; Mohammed ALDOSARI ; Hawraa AL-SHAMMARI ; Fatema AL-FARAJ ; Saba EL-HAG ; Mohamed TOLEFAT ; Mogahed ALI ; Bisher NASIR ; Thomas W. FRAZIER in Autism Research, 16-12 (December 2023)  

Public ISBD [article]  inAutism Research > 16-12 (December 2023) . - p.2291-2301 Titre : Development and validation of an Arabic language eye-tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar Type de document : texte imprimé Auteurs : Iman GHAZAL, Auteur ; I. Richard THOMPSON, Auteur ; Eric W. KLINGEMIER, Auteur ; Mohammed ALDOSARI, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Fatema AL-FARAJ, Auteur ; Saba EL-HAG, Auteur ; Mohamed TOLEFAT, Auteur ; Mogahed ALI, Auteur ; Bisher NASIR, Auteur ; Thomas W. FRAZIER, Auteur Article en page(s) : p.2291-2301 Index. décimale : PER Périodiques Résumé : Abstract Abnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD). The primary aim of the present research was to develop an Arabic version of an objective measure of ASD, the "autism index" (AI), based on eye gaze tracking to social and nonsocial stimuli validated initially in the United States. The initial phase of this study included the translation of English language eye-tracking stimuli into stimuli appropriate for an Arabic-speaking culture. During the second phase, we tested it on a total of 144 children with ASD, and 96 controls. The AI had excellent internal consistency and test-retest reliability. Moreover, the AI showed good differentiation of ASD from control cases (AUC = 0.730, SE = 0.035). The AI was significantly positively correlated with SCQ total raw scores (r = 0.46, p<0.001). ADOS-2 scores were only available in the ASD group and did not show a significant relationship with AI scores (r = 0.10, p = 0.348), likely due to the restricted range. The AI, when implemented using Arabic-translated stimuli in a Qatari sample, showed good diagnostic differentiation and a strong correlation with parent-reported ASD symptoms. Thus, the AI appears to have cross-cultural validity and may be useful as a diagnostic aide to inform clinical judgment and track ASD symptom levels as part of the evaluation process. En ligne : https://doi.org/10.1002/aur.3046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Development and validation of an Arabic language eye-tracking paradigm for the early screening and diagnosis of autism spectrum disorders in Qatar [texte imprimé] / Iman GHAZAL, Auteur ; I. Richard THOMPSON, Auteur ; Eric W. KLINGEMIER, Auteur ; Mohammed ALDOSARI, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Fatema AL-FARAJ, Auteur ; Saba EL-HAG, Auteur ; Mohamed TOLEFAT, Auteur ; Mogahed ALI, Auteur ; Bisher NASIR, Auteur ; Thomas W. FRAZIER, Auteur . - p.2291-2301. in Autism Research > 16-12 (December 2023) . - p.2291-2301 Index. décimale : PER Périodiques Résumé : Abstract Abnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD). The primary aim of the present research was to develop an Arabic version of an objective measure of ASD, the "autism index" (AI), based on eye gaze tracking to social and nonsocial stimuli validated initially in the United States. The initial phase of this study included the translation of English language eye-tracking stimuli into stimuli appropriate for an Arabic-speaking culture. During the second phase, we tested it on a total of 144 children with ASD, and 96 controls. The AI had excellent internal consistency and test-retest reliability. Moreover, the AI showed good differentiation of ASD from control cases (AUC = 0.730, SE = 0.035). The AI was significantly positively correlated with SCQ total raw scores (r = 0.46, p<0.001). ADOS-2 scores were only available in the ASD group and did not show a significant relationship with AI scores (r = 0.10, p = 0.348), likely due to the restricted range. The AI, when implemented using Arabic-translated stimuli in a Qatari sample, showed good diagnostic differentiation and a strong correlation with parent-reported ASD symptoms. Thus, the AI appears to have cross-cultural validity and may be useful as a diagnostic aide to inform clinical judgment and track ASD symptom levels as part of the evaluation process. En ligne : https://doi.org/10.1002/aur.3046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Development and Validation of a Short Version Eye-Tracking Paradigm for the Screening and Diagnosis of Autism Spectrum Disorder in Qatar / Fouad Al SHABAN in Autism Research, 19-6 (June 2026)  

Public ISBD [article]  inAutism Research > 19-6 (June 2026) . - p.e70242 Titre : Development and Validation of a Short Version Eye-Tracking Paradigm for the Screening and Diagnosis of Autism Spectrum Disorder in Qatar Type de document : texte imprimé Auteurs : Fouad Al SHABAN, Auteur ; Iman GHAZAL, Auteur ; Fatema AL-FARAJ, Auteur ; Sarah AQEL, Auteur ; I. Richard THOMPSON, Auteur Article en page(s) : p.e70242 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  diagnosis  eye-tracking  gaze behavior  rapid screening Index. décimale : PER Périodiques Résumé : ABSTRACT Objective behavioral assessments for autism spectrum disorder (ASD) are often time-intensive and require substantial clinical expertise. Eye-tracking?based paradigms offer quantifiable measures of social attention that can complement traditional tools. The current study builds on our previously validated Arabic-language Autism Index (AI) by developing and validating a 4?min short version designed to improve feasibility in clinical and community settings while maintaining diagnostic accuracy. A total of 236 participants (127 with ASD, 109 non-autistic controls including those with developmental delays (DD)) aged 1?16?years were assessed using an eye-tracking paradigm consisting of 19 short dynamic videos depicting social and non-social scenes. The AI was computed as the ratio of dwell time toward social versus non-social stimuli. Diagnostic classification was established using ADOS-2 and SCQ. Reliability and validity were assessed using Cronbach's α, Pearson's r, and ROC analyses, including age-stratified performance and comparison with the original 10?min version. Feasibility was assessed by the proportion of valid stimuli. The short-version AI demonstrated excellent internal consistency (α?=?0.91) and test?retest reliability (r?=?0.83). Diagnostic accuracy was high (AUC?=?0.878, SE?=?0.023), with age-stratified AUCs ranging from 0.846 to 0.939. AI scores correlated strongly with ADOS-2 severity (r?=?0.54, p? En ligne : https://doi.org/10.1002/aur.70242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Development and Validation of a Short Version Eye-Tracking Paradigm for the Screening and Diagnosis of Autism Spectrum Disorder in Qatar [texte imprimé] / Fouad Al SHABAN, Auteur ; Iman GHAZAL, Auteur ; Fatema AL-FARAJ, Auteur ; Sarah AQEL, Auteur ; I. Richard THOMPSON, Auteur . - p.e70242. Langues : Anglais (eng) in Autism Research > 19-6 (June 2026) . - p.e70242 Mots-clés : autism spectrum disorder  diagnosis  eye-tracking  gaze behavior  rapid screening Index. décimale : PER Périodiques Résumé : ABSTRACT Objective behavioral assessments for autism spectrum disorder (ASD) are often time-intensive and require substantial clinical expertise. Eye-tracking?based paradigms offer quantifiable measures of social attention that can complement traditional tools. The current study builds on our previously validated Arabic-language Autism Index (AI) by developing and validating a 4?min short version designed to improve feasibility in clinical and community settings while maintaining diagnostic accuracy. A total of 236 participants (127 with ASD, 109 non-autistic controls including those with developmental delays (DD)) aged 1?16?years were assessed using an eye-tracking paradigm consisting of 19 short dynamic videos depicting social and non-social scenes. The AI was computed as the ratio of dwell time toward social versus non-social stimuli. Diagnostic classification was established using ADOS-2 and SCQ. Reliability and validity were assessed using Cronbach's α, Pearson's r, and ROC analyses, including age-stratified performance and comparison with the original 10?min version. Feasibility was assessed by the proportion of valid stimuli. The short-version AI demonstrated excellent internal consistency (α?=?0.91) and test?retest reliability (r?=?0.83). Diagnostic accuracy was high (AUC?=?0.878, SE?=?0.023), with age-stratified AUCs ranging from 0.846 to 0.939. AI scores correlated strongly with ADOS-2 severity (r?=?0.54, p? En ligne : https://doi.org/10.1002/aur.70242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

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