Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder / Esen YILDIRIM DEMIRDÖĞEN in Research in Autism Spectrum Disorders, 112 (April 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 112 (April 2024) . - p.102327 Titre : Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Esen YILDIRIM DEMIRDÖĞEN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERIÅž, Auteur ; Nezahat KURT, Auteur ; Neslihan YÃœCE, Auteur Article en page(s) : p.102327 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Hypoxia-inducible factor-1 alpha (HIF-1?)  Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1 and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1 and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1 and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1 and apelin serum levels were compared between groups. Additionally, correlations between HIF-1 and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1 and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r =  0.430, p = 0.018). Serum HIF-1 levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1 and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1 , apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder [texte imprimé] / Esen YILDIRIM DEMIRDÖĞEN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERIÅž, Auteur ; Nezahat KURT, Auteur ; Neslihan YÃœCE, Auteur . - p.102327. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327 Mots-clés : Autism spectrum disorder  Hypoxia-inducible factor-1 alpha (HIF-1?)  Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1 and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1 and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1 and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1 and apelin serum levels were compared between groups. Additionally, correlations between HIF-1 and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1 and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r =  0.430, p = 0.018). Serum HIF-1 levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1 and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1 , apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

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