Mid-childhood autism sibling recurrence in infants with a family history of autism / Rowan ARTHUR ; Greg PASCO ; Elizabeth SHEPHARD ; Bosiljka MILOSAVLJEVIC ; Jannath Begum ALI ; Andrew PICKLES ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN ; The BASIS/STAARS TEAM in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1501-1514 Titre : Mid-childhood autism sibling recurrence in infants with a family history of autism Type de document : Texte imprimé et/ou numérique Auteurs : Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur Article en page(s) : p.1501-1514 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Mid-childhood autism sibling recurrence in infants with a family history of autism [Texte imprimé et/ou numérique] / Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur . - p.1501-1514. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1501-1514 Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

---

1 (1 - 1 / 1)