Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome / Françoise S. MAHEU in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1177-1189 Titre : Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome Type de document : texte imprimé Auteurs : Françoise S. MAHEU, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Luigi MAZZONE, Auteur ; Deborah P. MERKE, Auteur ; Margaret F. KEIL, Auteur ; Constantine A. STRATAKIS, Auteur Année de publication : 2008 Article en page(s) : p.1177-1189 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they represent a unique natural model to study the effects of prolonged hypercortisolemia on brain function, and memory and affective processes during this developmental stage. Using functional magnetic resonance imaging (fMRI), we compared 12 adolescents with Cushing syndrome with 22 healthy control adolescents on amygdala and anterior hippocampus activation during an emotional faces encoding task. None of these adolescents manifested depressive symptoms. Encoding success was assessed using a memory recognition test performed after the scan. The fMRI analyses followed an event-related design and were conducted using the SPM99 platform. Compared to healthy adolescents, patients with Cushing syndrome showed greater left amygdala and right anterior hippocampus activation during successful face encoding. Memory performance for faces recognition did not differ between groups. This first study of cerebral function in adolescents with chronic endogeneous hypercortisolemia due to Cushing syndrome demonstrates the presence of functional alterations in amygdala and hippocampus, which are not associated with affective or memory impairments. Such findings need to be followed by work examining the role of age and related brain maturational stage on these effects, as well as the identification of possible protective factors conferring resilience to affective and cognitive consequences in this disease and/or during this stage of cerebral development. En ligne : http://dx.doi.org/10.1017/s0954579408000564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602 [article] Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome [texte imprimé] / Françoise S. MAHEU, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Luigi MAZZONE, Auteur ; Deborah P. MERKE, Auteur ; Margaret F. KEIL, Auteur ; Constantine A. STRATAKIS, Auteur . - 2008 . - p.1177-1189. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1177-1189 Index. décimale : PER Périodiques Résumé : Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they represent a unique natural model to study the effects of prolonged hypercortisolemia on brain function, and memory and affective processes during this developmental stage. Using functional magnetic resonance imaging (fMRI), we compared 12 adolescents with Cushing syndrome with 22 healthy control adolescents on amygdala and anterior hippocampus activation during an emotional faces encoding task. None of these adolescents manifested depressive symptoms. Encoding success was assessed using a memory recognition test performed after the scan. The fMRI analyses followed an event-related design and were conducted using the SPM99 platform. Compared to healthy adolescents, patients with Cushing syndrome showed greater left amygdala and right anterior hippocampus activation during successful face encoding. Memory performance for faces recognition did not differ between groups. This first study of cerebral function in adolescents with chronic endogeneous hypercortisolemia due to Cushing syndrome demonstrates the presence of functional alterations in amygdala and hippocampus, which are not associated with affective or memory impairments. Such findings need to be followed by work examining the role of age and related brain maturational stage on these effects, as well as the identification of possible protective factors conferring resilience to affective and cognitive consequences in this disease and/or during this stage of cerebral development. En ligne : http://dx.doi.org/10.1017/s0954579408000564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602

Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood / Sabrina SUFFREN in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.957-968 Titre : Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood Type de document : texte imprimé Auteurs : Sabrina SUFFREN, Auteur ; Valérie LA BUISSONNIERE-ARIZA, Auteur ; Alan TUCHOLKA, Auteur ; Marouane NASSIM, Auteur ; Jean R. SEGUIN, Auteur ; Michel BOIVIN, Auteur ; Manpreet KAUR SINGH, Auteur ; Lara C. FOLAND-ROSS, Auteur ; Franco LEPORE, Auteur ; Ian H. GOTLIB, Auteur ; Richard E. TREMBLAY, Auteur ; Françoise S. MAHEU, Auteur Article en page(s) : p.957-968 Langues : Anglais (eng) Mots-clés : anxiety  FreeSurfer  internalized disorders  parental practices  VBM Index. décimale : PER Périodiques Résumé : Childhood adversity and anxiety have been associated with increased risk for internalizing disorders later in life and with a range of brain structural abnormalities. However, few studies have examined the link between harsh parenting practices and brain anatomy, outside of severe maltreatment or psychopathology. Moreover, to our knowledge, there has been no research on parenting and subclinical anxiety symptoms which remain persistent over time during childhood (i.e., between 2.5 and 9 years old). Here, we examined data in 94 youth, divided into four cells based on their levels of coercive parenting (high / low) and of anxiety (high / low) between 2.5 and 9 years old. Anatomical images were analyzed using voxel-based morphometry (VBM) and FreeSurfer. Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time. In addition, we observed significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume. These youth should be followed further in time to identify which youth will or will not go on to develop an anxiety disorder, and to understand factors associated with the development of sustained anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood [texte imprimé] / Sabrina SUFFREN, Auteur ; Valérie LA BUISSONNIERE-ARIZA, Auteur ; Alan TUCHOLKA, Auteur ; Marouane NASSIM, Auteur ; Jean R. SEGUIN, Auteur ; Michel BOIVIN, Auteur ; Manpreet KAUR SINGH, Auteur ; Lara C. FOLAND-ROSS, Auteur ; Franco LEPORE, Auteur ; Ian H. GOTLIB, Auteur ; Richard E. TREMBLAY, Auteur ; Françoise S. MAHEU, Auteur . - p.957-968. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.957-968 Mots-clés : anxiety  FreeSurfer  internalized disorders  parental practices  VBM Index. décimale : PER Périodiques Résumé : Childhood adversity and anxiety have been associated with increased risk for internalizing disorders later in life and with a range of brain structural abnormalities. However, few studies have examined the link between harsh parenting practices and brain anatomy, outside of severe maltreatment or psychopathology. Moreover, to our knowledge, there has been no research on parenting and subclinical anxiety symptoms which remain persistent over time during childhood (i.e., between 2.5 and 9 years old). Here, we examined data in 94 youth, divided into four cells based on their levels of coercive parenting (high / low) and of anxiety (high / low) between 2.5 and 9 years old. Anatomical images were analyzed using voxel-based morphometry (VBM) and FreeSurfer. Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time. In addition, we observed significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume. These youth should be followed further in time to identify which youth will or will not go on to develop an anxiety disorder, and to understand factors associated with the development of sustained anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

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