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Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood / Sabrina SUFFREN in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood Type de document : Texte imprimé et/ou numérique Auteurs : Sabrina SUFFREN, Auteur ; Valérie LA BUISSONNIERE-ARIZA, Auteur ; Alan TUCHOLKA, Auteur ; Marouane NASSIM, Auteur ; Jean R. SEGUIN, Auteur ; Michel BOIVIN, Auteur ; Manpreet KAUR SINGH, Auteur ; Lara C. FOLAND-ROSS, Auteur ; Franco LEPORE, Auteur ; Ian H. GOTLIB, Auteur ; Richard E. TREMBLAY, Auteur ; Françoise S. MAHEU, Auteur Article en page(s) : p.957-968 Langues : Anglais (eng) Mots-clés : anxiety FreeSurfer internalized disorders parental practices VBM Index. décimale : PER Périodiques Résumé : Childhood adversity and anxiety have been associated with increased risk for internalizing disorders later in life and with a range of brain structural abnormalities. However, few studies have examined the link between harsh parenting practices and brain anatomy, outside of severe maltreatment or psychopathology. Moreover, to our knowledge, there has been no research on parenting and subclinical anxiety symptoms which remain persistent over time during childhood (i.e., between 2.5 and 9 years old). Here, we examined data in 94 youth, divided into four cells based on their levels of coercive parenting (high / low) and of anxiety (high / low) between 2.5 and 9 years old. Anatomical images were analyzed using voxel-based morphometry (VBM) and FreeSurfer. Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time. In addition, we observed significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume. These youth should be followed further in time to identify which youth will or will not go on to develop an anxiety disorder, and to understand factors associated with the development of sustained anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Development and Psychopathology > 34-3 (August 2022) . - p.957-968[article] Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood [Texte imprimé et/ou numérique] / Sabrina SUFFREN, Auteur ; Valérie LA BUISSONNIERE-ARIZA, Auteur ; Alan TUCHOLKA, Auteur ; Marouane NASSIM, Auteur ; Jean R. SEGUIN, Auteur ; Michel BOIVIN, Auteur ; Manpreet KAUR SINGH, Auteur ; Lara C. FOLAND-ROSS, Auteur ; Franco LEPORE, Auteur ; Ian H. GOTLIB, Auteur ; Richard E. TREMBLAY, Auteur ; Françoise S. MAHEU, Auteur . - p.957-968.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.957-968
Mots-clés : anxiety FreeSurfer internalized disorders parental practices VBM Index. décimale : PER Périodiques Résumé : Childhood adversity and anxiety have been associated with increased risk for internalizing disorders later in life and with a range of brain structural abnormalities. However, few studies have examined the link between harsh parenting practices and brain anatomy, outside of severe maltreatment or psychopathology. Moreover, to our knowledge, there has been no research on parenting and subclinical anxiety symptoms which remain persistent over time during childhood (i.e., between 2.5 and 9 years old). Here, we examined data in 94 youth, divided into four cells based on their levels of coercive parenting (high / low) and of anxiety (high / low) between 2.5 and 9 years old. Anatomical images were analyzed using voxel-based morphometry (VBM) and FreeSurfer. Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time. In addition, we observed significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume. These youth should be followed further in time to identify which youth will or will not go on to develop an anxiety disorder, and to understand factors associated with the development of sustained anxiety psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder / Haruhisa OHTA in Autism Research, 9-2 (February 2016)
[article]
Titre : Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.232-248 Langues : Anglais (eng) Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.232-248[article] Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.232-248.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.232-248
Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282