GABA and glutamate measurements in temporal cortex of autistic children / Muhammad G. SALEH in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2558-2571 Titre : GABA and glutamate measurements in temporal cortex of autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Muhammad G. SALEH, Auteur ; Luke BLOY, Auteur ; Lisa BLASKEY, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.2558-2571 Langues : Anglais (eng) Mots-clés : autism  GABA  glutamate  MEGA-PRESS  MM-suppressed Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced by the levels of excitatory neurotransmitter glutamate (Glu) and inhibitory neurotransmitter ?-aminobutyric acid (GABA) in the brain. Although many have reported the levels of GABA and Glu in the brain, only a few reports address the temporal cortex and then only with a small sample of autistic children, and often only in one hemisphere. We used a macromolecular suppressed edited-magnetic resonance spectroscopy (MRS) sequence to study GABA and Glu (as potential key players influencing E/I) in a large sample of children with ASD in the right and left temporal cortices of children with (N?=?56) and without (N?=?30) ASD (7?18?years). As a group, children with ASD exhibited no differences in the left hemisphere (GABA and Glu Cohen's |d|: 0.24 and 0.03), but the right hemisphere showed higher GABA and lower Glu concentrations (GABA and Glu Cohen's |d|: 0.53 and 0.65) compared to neurotypicals. Furthermore, a negative association was found between the right hemisphere Glu levels of the ASD group and a clinical assessment tool (r?=??0.361, p?=?0.022), reflecting autism trait severity (social responsiveness scale). In conclusion, we highlight the chemical abnormalities in children with ASD through a cross-sectional measurement. Longitudinal studies are warranted to determine whether these chemical levels persist or resolve over development. En ligne : https://dx.doi.org/10.1002/aur.3253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] GABA and glutamate measurements in temporal cortex of autistic children [Texte imprimé et/ou numérique] / Muhammad G. SALEH, Auteur ; Luke BLOY, Auteur ; Lisa BLASKEY, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.2558-2571. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2558-2571 Mots-clés : autism  GABA  glutamate  MEGA-PRESS  MM-suppressed Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced by the levels of excitatory neurotransmitter glutamate (Glu) and inhibitory neurotransmitter ?-aminobutyric acid (GABA) in the brain. Although many have reported the levels of GABA and Glu in the brain, only a few reports address the temporal cortex and then only with a small sample of autistic children, and often only in one hemisphere. We used a macromolecular suppressed edited-magnetic resonance spectroscopy (MRS) sequence to study GABA and Glu (as potential key players influencing E/I) in a large sample of children with ASD in the right and left temporal cortices of children with (N?=?56) and without (N?=?30) ASD (7?18?years). As a group, children with ASD exhibited no differences in the left hemisphere (GABA and Glu Cohen's |d|: 0.24 and 0.03), but the right hemisphere showed higher GABA and lower Glu concentrations (GABA and Glu Cohen's |d|: 0.53 and 0.65) compared to neurotypicals. Furthermore, a negative association was found between the right hemisphere Glu levels of the ASD group and a clinical assessment tool (r?=??0.361, p?=?0.022), reflecting autism trait severity (social responsiveness scale). In conclusion, we highlight the chemical abnormalities in children with ASD through a cross-sectional measurement. Longitudinal studies are warranted to determine whether these chemical levels persist or resolve over development. En ligne : https://dx.doi.org/10.1002/aur.3253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

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