[article]
| Titre : |
GABA and glutamate measurements in temporal cortex of autistic children |
| Type de document : |
texte imprimé |
| Auteurs : |
Muhammad G. SALEH, Auteur ; Luke BLOY, Auteur ; Lisa BLASKEY, Auteur ; Timothy P. L. ROBERTS, Auteur |
| Article en page(s) : |
p.2558-2571 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism GABA glutamate MEGA-PRESS MM-suppressed |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced by the levels of excitatory neurotransmitter glutamate (Glu) and inhibitory neurotransmitter ?-aminobutyric acid (GABA) in the brain. Although many have reported the levels of GABA and Glu in the brain, only a few reports address the temporal cortex and then only with a small sample of autistic children, and often only in one hemisphere. We used a macromolecular suppressed edited-magnetic resonance spectroscopy (MRS) sequence to study GABA and Glu (as potential key players influencing E/I) in a large sample of children with ASD in the right and left temporal cortices of children with (N 56) and without (N 30) ASD (7 18 years). As a group, children with ASD exhibited no differences in the left hemisphere (GABA and Glu Cohen's |d|: 0.24 and 0.03), but the right hemisphere showed higher GABA and lower Glu concentrations (GABA and Glu Cohen's |d|: 0.53 and 0.65) compared to neurotypicals. Furthermore, a negative association was found between the right hemisphere Glu levels of the ASD group and a clinical assessment tool (r 0.361, p 0.022), reflecting autism trait severity (social responsiveness scale). In conclusion, we highlight the chemical abnormalities in children with ASD through a cross-sectional measurement. Longitudinal studies are warranted to determine whether these chemical levels persist or resolve over development. |
| En ligne : |
https://dx.doi.org/10.1002/aur.3253 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 |
in Autism Research > 17-12 (December 2024) . - p.2558-2571
[article] GABA and glutamate measurements in temporal cortex of autistic children [texte imprimé] / Muhammad G. SALEH, Auteur ; Luke BLOY, Auteur ; Lisa BLASKEY, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.2558-2571. Langues : Anglais ( eng) in Autism Research > 17-12 (December 2024) . - p.2558-2571
| Mots-clés : |
autism GABA glutamate MEGA-PRESS MM-suppressed |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced by the levels of excitatory neurotransmitter glutamate (Glu) and inhibitory neurotransmitter ?-aminobutyric acid (GABA) in the brain. Although many have reported the levels of GABA and Glu in the brain, only a few reports address the temporal cortex and then only with a small sample of autistic children, and often only in one hemisphere. We used a macromolecular suppressed edited-magnetic resonance spectroscopy (MRS) sequence to study GABA and Glu (as potential key players influencing E/I) in a large sample of children with ASD in the right and left temporal cortices of children with (N 56) and without (N 30) ASD (7 18 years). As a group, children with ASD exhibited no differences in the left hemisphere (GABA and Glu Cohen's |d|: 0.24 and 0.03), but the right hemisphere showed higher GABA and lower Glu concentrations (GABA and Glu Cohen's |d|: 0.53 and 0.65) compared to neurotypicals. Furthermore, a negative association was found between the right hemisphere Glu levels of the ASD group and a clinical assessment tool (r 0.361, p 0.022), reflecting autism trait severity (social responsiveness scale). In conclusion, we highlight the chemical abnormalities in children with ASD through a cross-sectional measurement. Longitudinal studies are warranted to determine whether these chemical levels persist or resolve over development. |
| En ligne : |
https://dx.doi.org/10.1002/aur.3253 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 |
|  |
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