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Auteur Luke BLOY |
Documents disponibles écrits par cet auteur (9)
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Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder / J. MATSUZAKI in Autism Research, 12-8 (August 2019)
[article]
Titre : Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. MATSUZAKI, Auteur ; E. S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; M. KIM, Auteur ; M. KU, Auteur ; J. C. EDGAR, Auteur ; D. EMBICK, Auteur ; T. P. L. ROBERTS, Auteur Article en page(s) : p.1225-1235 Langues : Anglais (eng) Mots-clés : autism spectrum disorder language and communication skill magnetoencephalography minimally verbal/non-verbal children vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Autism Research > 12-8 (August 2019) . - p.1225-1235[article] Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder [Texte imprimé et/ou numérique] / J. MATSUZAKI, Auteur ; E. S. KUSCHNER, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; M. KIM, Auteur ; M. KU, Auteur ; J. C. EDGAR, Auteur ; D. EMBICK, Auteur ; T. P. L. ROBERTS, Auteur . - p.1225-1235.
Langues : Anglais (eng)
in Autism Research > 12-8 (August 2019) . - p.1225-1235
Mots-clés : autism spectrum disorder language and communication skill magnetoencephalography minimally verbal/non-verbal children vowel mismatch fields Index. décimale : PER Périodiques Résumé : Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 +/- 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 +/- 1.21 years, ASD-LI: n = 21, 10.67 +/- 1.20 years) and TD: n = 27, 10.14 +/- 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain imaging showed abnormal auditory discrimination processes in minimally-verbal/non-verbal children (MVNV) who have autism spectrum disorder (ASD). Delays in auditory discrimination were associated with impaired language and communication skills. Findings suggest these auditory neural measures may be objective markers of language and communication skills in both verbal and, previously-understudied, MVNV children who have ASD. En ligne : http://dx.doi.org/10.1002/aur.2136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder / T. P. L. ROBERTS in Molecular Autism, 10 (2019)
[article]
Titre : Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. P. L. ROBERTS, Auteur ; J. MATSUZAKI, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; J. C. EDGAR, Auteur ; M. KIM, Auteur ; M. KU, Auteur ; E. S. KUSCHNER, Auteur ; D. EMBICK, Auteur Article en page(s) : 34 p. Langues : Anglais (eng) Mots-clés : Auditory cortex Autism spectrum disorder M50/M100 responses and language impairment Magnetoencephalography Minimally verbal/non-verbal children Nonverbal Index. décimale : PER Périodiques Résumé : Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD). Some studies have reported an association between delays in these responses and language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during auditory processing in minimally verbal or nonverbal children who have ASD (ASD-MVNV)-children with little or no speech and often significant cognitive impairment. To understand the neurophysiological mechanisms underlying auditory processing in ASD-MVNV children, magnetoencephalography (MEG) measured M50 and M100 responses arising from left and right superior temporal gyri during tone stimuli in three cohorts: (1) MVNV children who have ASD (ASD-MVNV), (2) verbal children who have ASD and no intellectual disability (ASD-V), and (3) typically developing (TD) children. One hundred and five participants (8-12 years) were included in the final analyses (ASD-MVNV: n = 16, 9.85 +/- 1.32 years; ASD-V: n = 55, 10.64 +/- 1.31 years; TD: n = 34, 10.18 +/- 1.36 years). ASD-MVNV children showed significantly delayed M50 and M100 latencies compared to TD. These delays tended to be greater than the corresponding delays in verbal children with ASD. Across cohorts, delayed latencies were associated with language and communication skills, assessed by the Vineland Adaptive Behavior Scale Communication Domain. Findings suggest that auditory cortex neural activity measures could be dimensional objective indices of language impairment in ASD for either diagnostic (e.g., via threshold or cutoff) or prognostic (considering the continuous variable) use. En ligne : https://dx.doi.org/10.1186/s13229-019-0283-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Molecular Autism > 10 (2019) . - 34 p.[article] Delayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder [Texte imprimé et/ou numérique] / T. P. L. ROBERTS, Auteur ; J. MATSUZAKI, Auteur ; Lisa BLASKEY, Auteur ; Luke BLOY, Auteur ; J. C. EDGAR, Auteur ; M. KIM, Auteur ; M. KU, Auteur ; E. S. KUSCHNER, Auteur ; D. EMBICK, Auteur . - 34 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 34 p.
Mots-clés : Auditory cortex Autism spectrum disorder M50/M100 responses and language impairment Magnetoencephalography Minimally verbal/non-verbal children Nonverbal Index. décimale : PER Périodiques Résumé : Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD). Some studies have reported an association between delays in these responses and language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during auditory processing in minimally verbal or nonverbal children who have ASD (ASD-MVNV)-children with little or no speech and often significant cognitive impairment. To understand the neurophysiological mechanisms underlying auditory processing in ASD-MVNV children, magnetoencephalography (MEG) measured M50 and M100 responses arising from left and right superior temporal gyri during tone stimuli in three cohorts: (1) MVNV children who have ASD (ASD-MVNV), (2) verbal children who have ASD and no intellectual disability (ASD-V), and (3) typically developing (TD) children. One hundred and five participants (8-12 years) were included in the final analyses (ASD-MVNV: n = 16, 9.85 +/- 1.32 years; ASD-V: n = 55, 10.64 +/- 1.31 years; TD: n = 34, 10.18 +/- 1.36 years). ASD-MVNV children showed significantly delayed M50 and M100 latencies compared to TD. These delays tended to be greater than the corresponding delays in verbal children with ASD. Across cohorts, delayed latencies were associated with language and communication skills, assessed by the Vineland Adaptive Behavior Scale Communication Domain. Findings suggest that auditory cortex neural activity measures could be dimensional objective indices of language impairment in ASD for either diagnostic (e.g., via threshold or cutoff) or prognostic (considering the continuous variable) use. En ligne : https://dx.doi.org/10.1186/s13229-019-0283-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development / Heather L. GREEN in Journal of Autism and Developmental Disorders, 53-10 (October 2023)
[article]
Titre : Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur Article en page(s) : p.4076-4089 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511
in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089[article] Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development [Texte imprimé et/ou numérique] / Heather L. GREEN, Auteur ; Guannan SHEN, Auteur ; Rose E. FRANZEN, Auteur ; Marybeth MCNAMEE, Auteur ; Jeffrey I. BERMAN, Auteur ; Theresa G. MOWAD, Auteur ; Matthew KU, Auteur ; Luke BLOY, Auteur ; Song LIU, Auteur ; Yu-Han CHEN, Auteur ; Megan AIREY, Auteur ; Emma MCBRIDE, Auteur ; Sophia GOLDIN, Auteur ; Marissa A. DIPIERO, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Mina KIM, Auteur ; Kimberly KONKA, Auteur ; Timothy P. L. ROBERTS, Auteur ; J. Christopher EDGAR, Auteur . - p.4076-4089.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.4076-4089
Index. décimale : PER Périodiques Résumé : Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained?~?18 months later at Time 2 (T2), and?~?36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time. En ligne : https://doi.org/10.1007/s10803-022-05696-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD / Russell G. PORT in Autism Research, 10-4 (April 2017)
[article]
Titre : Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.593-607 Langues : Anglais (eng) Mots-clés : magnetoencephalography gamma-band GABA MEGA-PRESS magnetic resonance spectroscopy auditory autism spectrum disorder excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-4 (April 2017) . - p.593-607[article] Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD [Texte imprimé et/ou numérique] / Russell G. PORT, Auteur ; William GAETZ, Auteur ; Luke BLOY, Auteur ; Dah-Jyuu WANG, Auteur ; Lisa BLASKEY, Auteur ; Emily S. KUSCHNER, Auteur ; Susan E. LEVY, Auteur ; Edward S. BRODKIN, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.593-607.
Langues : Anglais (eng)
in Autism Research > 10-4 (April 2017) . - p.593-607
Mots-clés : magnetoencephalography gamma-band GABA MEGA-PRESS magnetic resonance spectroscopy auditory autism spectrum disorder excitatory/inhibitory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is hypothesized to arise from imbalances between excitatory and inhibitory neurotransmission (E/I imbalance). Studies have demonstrated E/I imbalance in individuals with ASD and also corresponding rodent models. One neural process thought to be reliant on E/I balance is gamma-band activity (Gamma), with support arising from observed correlations between motor, as well as visual, Gamma and underlying GABA concentrations in healthy adults. Additionally, decreased Gamma has been observed in ASD individuals and relevant animal models, though the direct relationship between Gamma and GABA concentrations in ASD remains unexplored. This study combined magnetoencephalography (MEG) and edited magnetic resonance spectroscopy (MRS) in 27 typically developing individuals (TD) and 30 individuals with ASD. Auditory cortex localized phase-locked Gamma was compared to resting Superior Temporal Gyrus relative cortical GABA concentrations for both children/adolescents and adults. Children/adolescents with ASD exhibited significantly decreased GABA+/Creatine (Cr) levels, though typical Gamma. Additionally, these children/adolescents lacked the typical maturation of GABA+/Cr concentrations and gamma-band coherence. Furthermore, children/adolescents with ASD additionally failed to exhibit the typical GABA+/Cr to gamma-band coherence association. This altered coupling during childhood/adolescence may result in Gamma decreases observed in the adults with ASD. Therefore, individuals with ASD exhibit improper local neuronal circuitry maturation during a childhood/adolescence critical period, when GABA is involved in configuring of such circuit functioning. Provocatively a novel line of treatment is suggested (with a critical time window); by increasing neural GABA levels in children/adolescents with ASD, proper local circuitry maturation may be restored resulting in typical Gamma in adulthood. En ligne : http://dx.doi.org/10.1002/aur.1686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 Joint Analysis of Band-Specific Functional Connectivity and Signal Complexity in Autism / Yasser GHANBARI in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
[article]
Titre : Joint Analysis of Band-Specific Functional Connectivity and Signal Complexity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Yasser GHANBARI, Auteur ; Luke BLOY, Auteur ; J. CHRISTOPHER EDGAR, Auteur ; Lisa BLASKEY, Auteur ; Ragini VERMA, Auteur ; Timothy P. L. ROBERTS, Auteur Article en page(s) : p.444-460 Langues : Anglais (eng) Mots-clés : Autism Magnetoencephalography (MEG) Resting-state Connectivity Complexity Synchronization likelihood (SL) Multi-scale entropy (MSE) Index. décimale : PER Périodiques Résumé : Examination of resting state brain activity using electrophysiological measures like complexity as well as functional connectivity is of growing interest in the study of autism spectrum disorders (ASD). The present paper jointly examined complexity and connectivity to obtain a more detailed characterization of resting state brain activity in ASD. Multi-scale entropy was computed to quantify the signal complexity, and synchronization likelihood was used to evaluate functional connectivity (FC), with node strength values providing a sensor-level measure of connectivity to facilitate comparisons with complexity. Sensor level analysis of complexity and connectivity was performed at different frequency bands computed from resting state MEG from 26 children with ASD and 22 typically developing controls (TD). Analyses revealed band-specific group differences in each measure that agreed with other functional studies in fMRI and EEG: higher complexity in TD than ASD, in frontal regions in the delta band and occipital-parietal regions in the alpha band, and lower complexity in TD than in ASD in delta (parietal regions), theta (central and temporal regions) and gamma (frontal-central boundary regions); increased short-range connectivity in ASD in the frontal lobe in the delta band and long-range connectivity in the temporal, parietal and occipital lobes in the alpha band. Finally, and perhaps most strikingly, group differences between ASD and TD in complexity and FC appear spatially complementary, such that where FC was elevated in ASD, complexity was reduced (and vice versa). The correlation of regional average complexity and connectivity node strength with symptom severity scores of ASD subjects supported the overall complementarity (with opposing sign) of connectivity and complexity measures, pointing to either diminished connectivity leading to elevated entropy due to poor inhibitory regulation or chaotic signals prohibiting effective measure of connectivity. En ligne : http://dx.doi.org/10.1007/s10803-013-1915-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.444-460[article] Joint Analysis of Band-Specific Functional Connectivity and Signal Complexity in Autism [Texte imprimé et/ou numérique] / Yasser GHANBARI, Auteur ; Luke BLOY, Auteur ; J. CHRISTOPHER EDGAR, Auteur ; Lisa BLASKEY, Auteur ; Ragini VERMA, Auteur ; Timothy P. L. ROBERTS, Auteur . - p.444-460.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.444-460
Mots-clés : Autism Magnetoencephalography (MEG) Resting-state Connectivity Complexity Synchronization likelihood (SL) Multi-scale entropy (MSE) Index. décimale : PER Périodiques Résumé : Examination of resting state brain activity using electrophysiological measures like complexity as well as functional connectivity is of growing interest in the study of autism spectrum disorders (ASD). The present paper jointly examined complexity and connectivity to obtain a more detailed characterization of resting state brain activity in ASD. Multi-scale entropy was computed to quantify the signal complexity, and synchronization likelihood was used to evaluate functional connectivity (FC), with node strength values providing a sensor-level measure of connectivity to facilitate comparisons with complexity. Sensor level analysis of complexity and connectivity was performed at different frequency bands computed from resting state MEG from 26 children with ASD and 22 typically developing controls (TD). Analyses revealed band-specific group differences in each measure that agreed with other functional studies in fMRI and EEG: higher complexity in TD than ASD, in frontal regions in the delta band and occipital-parietal regions in the alpha band, and lower complexity in TD than in ASD in delta (parietal regions), theta (central and temporal regions) and gamma (frontal-central boundary regions); increased short-range connectivity in ASD in the frontal lobe in the delta band and long-range connectivity in the temporal, parietal and occipital lobes in the alpha band. Finally, and perhaps most strikingly, group differences between ASD and TD in complexity and FC appear spatially complementary, such that where FC was elevated in ASD, complexity was reduced (and vice versa). The correlation of regional average complexity and connectivity node strength with symptom severity scores of ASD subjects supported the overall complementarity (with opposing sign) of connectivity and complexity measures, pointing to either diminished connectivity leading to elevated entropy due to poor inhibitory regulation or chaotic signals prohibiting effective measure of connectivity. En ligne : http://dx.doi.org/10.1007/s10803-013-1915-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 A Multimodal Study of the Contributions of Conduction Velocity to the Auditory Evoked Neuromagnetic Response: Anomalies in Autism Spectrum Disorder / Timothy P. L. ROBERTS in Autism Research, 13-10 (October 2020)
PermalinkPeak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder / H. L. GREEN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
PermalinkResting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
PermalinkA Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder / Luke BLOY in Journal of Autism and Developmental Disorders, 49-8 (August 2019)
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