Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study / Julius HENNIG in Journal of Child Psychology and Psychiatry, 67-1 (January 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.79-91 Titre : Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study Type de document : texte imprimé Auteurs : Julius HENNIG, Auteur ; Ilka BOEHM, Auteur ; Katharina ZWOSTA, Auteur ; Joseph A. KING, Auteur ; Daniel GEISLER, Auteur ; Hannes RUGE, Auteur ; Maria SEIDEL, Auteur ; Fabio BERNARDONI, Auteur ; Inger HELLERHOFF, Auteur ; Arne DOOSE, Auteur ; Sophie PAULIGK, Auteur ; Henri LESCHZINSKI, Auteur ; Veit ROESSNER, Auteur ; Uta WOLFENSTELLER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.79-91 Langues : Anglais (eng) Mots-clés : Adolescence  neuroimaging  habitual behavior  avoidance  eating disorder Index. décimale : PER Périodiques Résumé : Background Anorexia nervosa (AN), often with an onset in adolescence, is a complex eating disorder characterized by distorted body image, fear of weight gain, and extreme food restriction, leading to severe underweight. Excessive goal pursuit and avoidance behaviors have been proposed as key factors in AN, which over time may become over-trained into habits. Methods This study investigated the behavioral and neural correlates of habit learning in AN with an experiment consisting of three consecutive phases: (1) training goal-directed behavior, (2) avoidance learning, and (3) a habit test. Forty-five acutely underweight adolescent female patients with AN and 45 age-matched healthy control participants underwent an fMRI scan. Results No behavioral group differences were evident either during learning of avoidance habits or when testing habit strength. Importantly, however, the AN group showed both generally superior task performance and increased involvement of the frontoparietal brain regions during habit learning. Conclusions Collectively, our findings provide novel evidence suggesting that excessive goal pursuit may predominate in young AN in an avoidance learning context. Future research should examine if this tendency develops into habit learning over time and investigate the speed and strength of avoidance habit formation in adults with a longer history of AN to further elucidate the intricate dynamic between goal-directed and habitual processes in the disorder. En ligne : https://doi.org/10.1111/jcpp.70019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577 [article] Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study [texte imprimé] / Julius HENNIG, Auteur ; Ilka BOEHM, Auteur ; Katharina ZWOSTA, Auteur ; Joseph A. KING, Auteur ; Daniel GEISLER, Auteur ; Hannes RUGE, Auteur ; Maria SEIDEL, Auteur ; Fabio BERNARDONI, Auteur ; Inger HELLERHOFF, Auteur ; Arne DOOSE, Auteur ; Sophie PAULIGK, Auteur ; Henri LESCHZINSKI, Auteur ; Veit ROESSNER, Auteur ; Uta WOLFENSTELLER, Auteur ; Stefan EHRLICH, Auteur . - p.79-91. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.79-91 Mots-clés : Adolescence  neuroimaging  habitual behavior  avoidance  eating disorder Index. décimale : PER Périodiques Résumé : Background Anorexia nervosa (AN), often with an onset in adolescence, is a complex eating disorder characterized by distorted body image, fear of weight gain, and extreme food restriction, leading to severe underweight. Excessive goal pursuit and avoidance behaviors have been proposed as key factors in AN, which over time may become over-trained into habits. Methods This study investigated the behavioral and neural correlates of habit learning in AN with an experiment consisting of three consecutive phases: (1) training goal-directed behavior, (2) avoidance learning, and (3) a habit test. Forty-five acutely underweight adolescent female patients with AN and 45 age-matched healthy control participants underwent an fMRI scan. Results No behavioral group differences were evident either during learning of avoidance habits or when testing habit strength. Importantly, however, the AN group showed both generally superior task performance and increased involvement of the frontoparietal brain regions during habit learning. Conclusions Collectively, our findings provide novel evidence suggesting that excessive goal pursuit may predominate in young AN in an avoidance learning context. Future research should examine if this tendency develops into habit learning over time and investigate the speed and strength of avoidance habit formation in adults with a longer history of AN to further elucidate the intricate dynamic between goal-directed and habitual processes in the disorder. En ligne : https://doi.org/10.1111/jcpp.70019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577

Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment / Julius HENNIG ; Arne DOOSE ; Clara Marie BREIER ; Alexander SOUTSCHEK ; Nicole BEYER ; Stefan SCHWEINBERGER ; Inge KAMP-BECKER ; Luise POUSTKA ; Katja ALBERTOWSKI ; Veit ROESSNER ; Stefan EHRLICH in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.349-361 Titre : Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research Type de document : texte imprimé Auteurs : Julius HENNIG, Auteur ; Arne DOOSE, Auteur ; Clara Marie BREIER, Auteur ; Alexander SOUTSCHEK, Auteur ; Nicole BEYER, Auteur ; Stefan SCHWEINBERGER, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur ; Katja ALBERTOWSKI, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.349-361 Langues : Anglais (eng) Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n 29) to neurotypical controls (n 39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research [texte imprimé] / Julius HENNIG, Auteur ; Arne DOOSE, Auteur ; Clara Marie BREIER, Auteur ; Alexander SOUTSCHEK, Auteur ; Nicole BEYER, Auteur ; Stefan SCHWEINBERGER, Auteur ; Inge KAMP-BECKER, Auteur ; Luise POUSTKA, Auteur ; Katja ALBERTOWSKI, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur . - p.349-361. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.349-361 Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n 29) to neurotypical controls (n 39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks / Inger HELLERHOFF in Journal of Child Psychology and Psychiatry, 67-6 (June 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.907-918 Titre : Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks Type de document : texte imprimé Auteurs : Inger HELLERHOFF, Auteur ; Daniel GEISLER, Auteur ; Fabio BERNARDONI, Auteur ; Arne DOOSE, Auteur ; Friederike I. TAM, Auteur ; David M. POITZ, Auteur ; Nina CHOTJEWITZ, Auteur ; Veit ROESSNER, Auteur ; Katja AKGÃœN, Auteur ; Tjalf ZIEMSSEN, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.907-918 Langues : Anglais (eng) Mots-clés : Anorexia nervosa  neurofilament light  white matter volume  white matter connectivity  leptin Index. décimale : PER Périodiques Résumé : Background Anorexia nervosa (AN) is a severe eating disorder associated with drastic reductions in gray and white matter (WM) volume and structural connectivity alterations. However, the hypotheses regarding underlying mechanisms are inconclusive. The current study investigated the relationships of WM volume as well as WM network architecture with neurofilament light (NF-L), a marker of axonal damage. Methods Blood samples and magnetic resonance imaging scans from 77 predominantly adolescent female participants with acute AN were used. Associations of WM volume with NF-L were tested using linear models. The relationship between NF-L and alterations in brain networks was evaluated using network-based statistic (NBS) models, which predicted connectivity associated with NF-L levels. Additionally, associations with clinical variables and leptin were tested. To test the specificity of the results, control analyses were conducted on 77 female healthy participants (HC). Results We found negative associations between NF-L concentrations and WM volume. NBS analyses identified seven components, where fractional anisotropy was positively associated with NF-L. In some components, mean connectivity was negatively associated with leptin concentrations. Mediation analyses suggested that the negative correlation of leptin and NF-L might be partially mediated by changes in WM microstructure. These effects were not observed in HC. Conclusions The results suggest that WM volume reductions in acute AN might be related to axonal damage. The NBS results indicate, that the elevated fractional anisotropy previously found in AN might be related to damage processes leading to axonal swelling. All in all, the present study supports NF-L as a global blood marker for brain damage processes in acute AN. En ligne : https://doi.org/10.1111/jcpp.70083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks [texte imprimé] / Inger HELLERHOFF, Auteur ; Daniel GEISLER, Auteur ; Fabio BERNARDONI, Auteur ; Arne DOOSE, Auteur ; Friederike I. TAM, Auteur ; David M. POITZ, Auteur ; Nina CHOTJEWITZ, Auteur ; Veit ROESSNER, Auteur ; Katja AKGÃœN, Auteur ; Tjalf ZIEMSSEN, Auteur ; Stefan EHRLICH, Auteur . - p.907-918. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.907-918 Mots-clés : Anorexia nervosa  neurofilament light  white matter volume  white matter connectivity  leptin Index. décimale : PER Périodiques Résumé : Background Anorexia nervosa (AN) is a severe eating disorder associated with drastic reductions in gray and white matter (WM) volume and structural connectivity alterations. However, the hypotheses regarding underlying mechanisms are inconclusive. The current study investigated the relationships of WM volume as well as WM network architecture with neurofilament light (NF-L), a marker of axonal damage. Methods Blood samples and magnetic resonance imaging scans from 77 predominantly adolescent female participants with acute AN were used. Associations of WM volume with NF-L were tested using linear models. The relationship between NF-L and alterations in brain networks was evaluated using network-based statistic (NBS) models, which predicted connectivity associated with NF-L levels. Additionally, associations with clinical variables and leptin were tested. To test the specificity of the results, control analyses were conducted on 77 female healthy participants (HC). Results We found negative associations between NF-L concentrations and WM volume. NBS analyses identified seven components, where fractional anisotropy was positively associated with NF-L. In some components, mean connectivity was negatively associated with leptin concentrations. Mediation analyses suggested that the negative correlation of leptin and NF-L might be partially mediated by changes in WM microstructure. These effects were not observed in HC. Conclusions The results suggest that WM volume reductions in acute AN might be related to axonal damage. The NBS results indicate, that the elevated fractional anisotropy previously found in AN might be related to damage processes leading to axonal swelling. All in all, the present study supports NF-L as a global blood marker for brain damage processes in acute AN. En ligne : https://doi.org/10.1111/jcpp.70083 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

---

1 (1 - 3 / 3) Par page : 25 50 100 200