A study on carbamazepine levels, including estimation of 10-11 epoxy-carbamazepine and levels in free plasma and saliva / P. I. TOMLIN in Developmental Medicine & Child Neurology, 28-6 (December 1986)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 28-6 (December 1986) . - p.713-718 Titre : A study on carbamazepine levels, including estimation of 10-11 epoxy-carbamazepine and levels in free plasma and saliva Type de document : Texte imprimé et/ou numérique Auteurs : P. I. TOMLIN, Auteur ; Ian MCKINLAY, Auteur ; I. SMITH, Auteur Année de publication : 1986 Article en page(s) : p.713-718 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Blood and saliva were collected from 48 children, aged three to 17 years, before a morning dose of carbamazepine and then at three, six and eight hours afterward. There was no significant difference in the ratio of 10-11 epoxy-carbamazepine to total carbamazepine for children on carbamazepine alone (0.18) and those on an additional anticonvulsant (0.19). 11 children were studied on their first day of therapy. Though four of them achieved levels of total carbamazepine which would have given a readily measurable 10-11 epoxide on the above ratio, 10 of the 11 consistently had levels less than 4 mumol/l. This may be of help in detecting non-compliance. For 16 children free carbamazepine also was estimated and there was an over-all correlation coefficient of 0.85 between saliva and free-drug levels. The proportion of free to total carbamazepine varied between 19 and 54 per cent. There was a significantly higher proportion of free drug at the pre-dose sampling time than at other times. Protein binding of carbamazepine therefore is very variable and saliva estimations can contribute usefully to the monitoring of drug levels. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620 [article] A study on carbamazepine levels, including estimation of 10-11 epoxy-carbamazepine and levels in free plasma and saliva [Texte imprimé et/ou numérique] / P. I. TOMLIN, Auteur ; Ian MCKINLAY, Auteur ; I. SMITH, Auteur . - 1986 . - p.713-718. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 28-6 (December 1986) . - p.713-718 Index. décimale : PER Périodiques Résumé : Blood and saliva were collected from 48 children, aged three to 17 years, before a morning dose of carbamazepine and then at three, six and eight hours afterward. There was no significant difference in the ratio of 10-11 epoxy-carbamazepine to total carbamazepine for children on carbamazepine alone (0.18) and those on an additional anticonvulsant (0.19). 11 children were studied on their first day of therapy. Though four of them achieved levels of total carbamazepine which would have given a readily measurable 10-11 epoxide on the above ratio, 10 of the 11 consistently had levels less than 4 mumol/l. This may be of help in detecting non-compliance. For 16 children free carbamazepine also was estimated and there was an over-all correlation coefficient of 0.85 between saliva and free-drug levels. The proportion of free to total carbamazepine varied between 19 and 54 per cent. There was a significantly higher proportion of free drug at the pre-dose sampling time than at other times. Protein binding of carbamazepine therefore is very variable and saliva estimations can contribute usefully to the monitoring of drug levels. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=620

The Performance of the First Year Inventory (FYI) Screening on a Sample of High-Risk 12-Month-Olds Diagnosed with Autism Spectrum Disorder (ASD) at 36 Months / H. Y. LEE in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4957-4973 Titre : The Performance of the First Year Inventory (FYI) Screening on a Sample of High-Risk 12-Month-Olds Diagnosed with Autism Spectrum Disorder (ASD) at 36 Months Type de document : Texte imprimé et/ou numérique Auteurs : H. Y. LEE, Auteur ; C. VIGEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; I. SMITH, Auteur ; Jessica BRIAN, Auteur ; Linda R. WATSON, Auteur ; Elizabeth R. CRAIS, Auteur ; Lauren M. TURNER-BROWN, Auteur ; J. S. REZNICK, Auteur ; Grace T. BARANEK, Auteur Article en page(s) : p.4957-4973 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  First Year Inventory  High-risk infants  Sensory reactivity and regulation  Social-communication Index. décimale : PER Périodiques Résumé : This study examined the performance of the First Year Inventory (FYI; version 2.0), a community-normed parent-reported screening instrument, in a high-risk (HR) sample of 12-month-olds with older siblings diagnosed with autism spectrum disorder (ASD). The FYI 2.0 was completed by parents of 86 HR infants and 35 low-risk control infants at age 12 months, followed by clinical diagnosis at 36 months. HR infants later diagnosed with ASD had significantly higher FYI 2.0 risk scores in both the social-communication and sensory-regulatory domains than typically developing infants. New FYI 2.0 cutoff scores for HR sample were explored by evaluating various cutoff options after considering tradeoffs between sensitivity and specificity and sample characteristics. En ligne : http://dx.doi.org/10.1007/s10803-019-04208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] The Performance of the First Year Inventory (FYI) Screening on a Sample of High-Risk 12-Month-Olds Diagnosed with Autism Spectrum Disorder (ASD) at 36 Months [Texte imprimé et/ou numérique] / H. Y. LEE, Auteur ; C. VIGEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; I. SMITH, Auteur ; Jessica BRIAN, Auteur ; Linda R. WATSON, Auteur ; Elizabeth R. CRAIS, Auteur ; Lauren M. TURNER-BROWN, Auteur ; J. S. REZNICK, Auteur ; Grace T. BARANEK, Auteur . - p.4957-4973. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4957-4973 Mots-clés : Autism spectrum disorder  First Year Inventory  High-risk infants  Sensory reactivity and regulation  Social-communication Index. décimale : PER Périodiques Résumé : This study examined the performance of the First Year Inventory (FYI; version 2.0), a community-normed parent-reported screening instrument, in a high-risk (HR) sample of 12-month-olds with older siblings diagnosed with autism spectrum disorder (ASD). The FYI 2.0 was completed by parents of 86 HR infants and 35 low-risk control infants at age 12 months, followed by clinical diagnosis at 36 months. HR infants later diagnosed with ASD had significantly higher FYI 2.0 risk scores in both the social-communication and sensory-regulatory domains than typically developing infants. New FYI 2.0 cutoff scores for HR sample were explored by evaluating various cutoff options after considering tradeoffs between sensitivity and specificity and sample characteristics. En ligne : http://dx.doi.org/10.1007/s10803-019-04208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

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