Consanguinity as a Risk Factor for Autism / Mohammad ALDOSARI ; Iman GHAZAL ; Hawraa AL-SHAMMARI ; Saba ELHAG ; I. Richard THOMPSON ; Jennifer BRUDER ; Hibah SHAATH ; Fatema AL-FARAJ ; Mohamed TOLEFAT ; Assal NASIR ; Eric FOMBONNE in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1945-1952 Titre : Consanguinity as a Risk Factor for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad ALDOSARI, Auteur ; Iman GHAZAL, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba ELHAG, Auteur ; I. Richard THOMPSON, Auteur ; Jennifer BRUDER, Auteur ; Hibah SHAATH, Auteur ; Fatema AL-FARAJ, Auteur ; Mohamed TOLEFAT, Auteur ; Assal NASIR, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : p.1945-1952 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = .836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: .751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. En ligne : https://doi.org/10.1007/s10803-023-06137-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Consanguinity as a Risk Factor for Autism [Texte imprimé et/ou numérique] / Mohammad ALDOSARI, Auteur ; Iman GHAZAL, Auteur ; Hawraa AL-SHAMMARI, Auteur ; Saba ELHAG, Auteur ; I. Richard THOMPSON, Auteur ; Jennifer BRUDER, Auteur ; Hibah SHAATH, Auteur ; Fatema AL-FARAJ, Auteur ; Mohamed TOLEFAT, Auteur ; Assal NASIR, Auteur ; Eric FOMBONNE, Auteur . - p.1945-1952. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1945-1952 Index. décimale : PER Périodiques Résumé : Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = .836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: .751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. En ligne : https://doi.org/10.1007/s10803-023-06137-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

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