Otitis media, antibiotics, and risk of autism spectrum disorder / Theresa WIMBERLEY in Autism Research, 11-10 (October 2018)  

Public ISBD [article]  inAutism Research > 11-10 (October 2018) . - p.1432-1440 Titre : Otitis media, antibiotics, and risk of autism spectrum disorder Type de document : texte imprimé Auteurs : Theresa WIMBERLEY, Auteur ; Esben AGERBO, Auteur ; Carsten B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; Henriette Thisted HORSDAL, Auteur ; Preben Bo MORTENSEN, Auteur ; Wesley K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; Robert H. YOLKEN, Auteur Article en page(s) : p.1432-1440 Langues : Anglais (eng) Mots-clés : antibiotics  autism spectrum disorder  epidemiology  otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Otitis media, antibiotics, and risk of autism spectrum disorder [texte imprimé] / Theresa WIMBERLEY, Auteur ; Esben AGERBO, Auteur ; Carsten B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; Henriette Thisted HORSDAL, Auteur ; Preben Bo MORTENSEN, Auteur ; Wesley K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; Robert H. YOLKEN, Auteur . - p.1432-1440. Langues : Anglais (eng) in Autism Research > 11-10 (October 2018) . - p.1432-1440 Mots-clés : antibiotics  autism spectrum disorder  epidemiology  otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Parental psychopathology before and after the child's diagnosis of a mental disorder: a population-based matched cohort study / Hannah CHATWIN in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.994-1004 Titre : Parental psychopathology before and after the child's diagnosis of a mental disorder: a population-based matched cohort study Type de document : texte imprimé Auteurs : Hannah CHATWIN, Auteur ; Katrine HOLDE, Auteur ; Theresa WIMBERLEY, Auteur ; Søren DALSGAARD, Auteur ; Liselotte PETERSEN, Auteur Article en page(s) : p.994-1004 Langues : Anglais (eng) Mots-clés : Childhood mental disorders  parental psychopathology Index. décimale : PER Périodiques Résumé : Background More research is needed to understand psychopathology among parents of children with mental disorders in the years before and after the child is diagnosed. Here, we estimated the risk of mental disorders and psychotropic medication use in parents of children with versus without mental disorders and the temporal associations between child and parental psychopathology. Methods We conducted a population-based matched cohort study using Danish register data. The study population included child?parent pairs of all children diagnosed with a mental disorder of interest (attention-deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, anxiety disorder, mood disorder, eating disorder, substance use disorder, and schizophrenia spectrum disorder) by 18 years of age during the period 1999 2014 and a matched reference population. Each child with a diagnosis was matched to 10 children of the same sex and birth year who had not been diagnosed with the mental disorder of interest. For all parents, we estimated the yearly incidence proportion of parental mental disorders and prescriptions for psychotropic medications 4 years before and after the child's diagnosis. Results We observed a substantially increased risk of mental disorders and psychotropic medication use among parents of children with a mental disorder, compared to the reference population. On average, parents of children with a diagnosis had twice the odds of mood disorders, anxiety disorders, and prescriptions for anti-depressants and anti-psychotics. The incidence of mood and anxiety disorders peaked in the 1 2 years before and after the child's diagnosis. The incidence of parental prescriptions for psychotropic medications (particularly anti-psychotics) peaked in the year the child was diagnosed and in the 3 years before the child's diagnosis for anti-depressants and sleep medications. Conclusions This study demonstrates clear temporal associations between child and parental psychopathology, with parental psychopathology peaking in the years immediately before and after the child's diagnosis. En ligne : https://doi.org/10.1111/jcpp.14113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562 [article] Parental psychopathology before and after the child's diagnosis of a mental disorder: a population-based matched cohort study [texte imprimé] / Hannah CHATWIN, Auteur ; Katrine HOLDE, Auteur ; Theresa WIMBERLEY, Auteur ; Søren DALSGAARD, Auteur ; Liselotte PETERSEN, Auteur . - p.994-1004. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.994-1004 Mots-clés : Childhood mental disorders  parental psychopathology Index. décimale : PER Périodiques Résumé : Background More research is needed to understand psychopathology among parents of children with mental disorders in the years before and after the child is diagnosed. Here, we estimated the risk of mental disorders and psychotropic medication use in parents of children with versus without mental disorders and the temporal associations between child and parental psychopathology. Methods We conducted a population-based matched cohort study using Danish register data. The study population included child?parent pairs of all children diagnosed with a mental disorder of interest (attention-deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, anxiety disorder, mood disorder, eating disorder, substance use disorder, and schizophrenia spectrum disorder) by 18 years of age during the period 1999 2014 and a matched reference population. Each child with a diagnosis was matched to 10 children of the same sex and birth year who had not been diagnosed with the mental disorder of interest. For all parents, we estimated the yearly incidence proportion of parental mental disorders and prescriptions for psychotropic medications 4 years before and after the child's diagnosis. Results We observed a substantially increased risk of mental disorders and psychotropic medication use among parents of children with a mental disorder, compared to the reference population. On average, parents of children with a diagnosis had twice the odds of mood disorders, anxiety disorders, and prescriptions for anti-depressants and anti-psychotics. The incidence of mood and anxiety disorders peaked in the 1 2 years before and after the child's diagnosis. The incidence of parental prescriptions for psychotropic medications (particularly anti-psychotics) peaked in the year the child was diagnosed and in the 3 years before the child's diagnosis for anti-depressants and sleep medications. Conclusions This study demonstrates clear temporal associations between child and parental psychopathology, with parental psychopathology peaking in the years immediately before and after the child's diagnosis. En ligne : https://doi.org/10.1111/jcpp.14113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562

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