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Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review / J. LUKASIK in Journal of Autism and Developmental Disorders, 49-9 (September 2019)
[article]
Titre : Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review Type de document : Texte imprimé et/ou numérique Auteurs : J. LUKASIK, Auteur ; B. PATRO-GOLAB, Auteur ; A. HORVATH, Auteur ; R. BARON, Auteur ; H. SZAJEWSKA, Auteur Article en page(s) : p.3866-3876 Langues : Anglais (eng) Mots-clés : Antibiotics Autism Early life Risk factors Index. décimale : PER Périodiques Résumé : We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case-control study; in three other case-control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case-control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development. En ligne : http://dx.doi.org/10.1007/s10803-019-04093-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3866-3876[article] Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review [Texte imprimé et/ou numérique] / J. LUKASIK, Auteur ; B. PATRO-GOLAB, Auteur ; A. HORVATH, Auteur ; R. BARON, Auteur ; H. SZAJEWSKA, Auteur . - p.3866-3876.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3866-3876
Mots-clés : Antibiotics Autism Early life Risk factors Index. décimale : PER Périodiques Résumé : We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case-control study; in three other case-control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case-control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development. En ligne : http://dx.doi.org/10.1007/s10803-019-04093-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Otitis media, antibiotics, and risk of autism spectrum disorder / T. WIMBERLEY in Autism Research, 11-10 (October 2018)
[article]
Titre : Otitis media, antibiotics, and risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur Article en page(s) : p.1432-1440 Langues : Anglais (eng) Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-10 (October 2018) . - p.1432-1440[article] Otitis media, antibiotics, and risk of autism spectrum disorder [Texte imprimé et/ou numérique] / T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur . - p.1432-1440.
Langues : Anglais (eng)
in Autism Research > 11-10 (October 2018) . - p.1432-1440
Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Investigating the effects of cesarean delivery and antibiotic use in early childhood on risk of later attention deficit hyperactivity disorder / P. B. AXELSSON in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)
[article]
Titre : Investigating the effects of cesarean delivery and antibiotic use in early childhood on risk of later attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : P. B. AXELSSON, Auteur ; T. D. CLAUSEN, Auteur ; A. H. PETERSEN, Auteur ; I. HAGEMAN, Auteur ; A. PINBORG, Auteur ; L. V. KESSING, Auteur ; T. BERGHOLT, Auteur ; S. C. RASMUSSEN, Auteur ; N. KEIDING, Auteur ; E. C. L. LOKKEGAARD, Auteur Article en page(s) : p.151-159 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder antibiotics cesarean section microbiota sibling relations Index. décimale : PER Périodiques Résumé : BACKGROUND: Increasing attention deficit hyperactivity disorder (ADHD) incidence has been proposed to be caused by factors influencing microbiota in early life. We investigated the potential causality between ADHD and two surrogate markers for changes in children's microbiota: birth delivery mode and early childhood antibiotic use. METHOD: This population-based, prospective cohort study linked nationwide registers of data for native Danish singleton live births in Denmark from 1997 to 2010. Exposure variables were delivery mode and antibiotic use during the first 2 years of life. The main outcome measure was ADHD diagnosis or redeemed ADHD medication prescriptions. For statistical analysis, we used both advanced sibling models and a more traditional approach. RESULTS: We included 671,592 children, followed from their second birthday in the period 1999-2014 for 7,300,522 person-years. ADHD was diagnosed in 17,971. In total, 17.5% were born by cesarean delivery, and 72% received antibiotic treatment within their first 2 years of life. In the adjusted between-within sibling survival model, mode of delivery or antibiotics had no effect on ADHD when compared with vaginal delivery or no antibiotic treatment as hazard ratios were 1.09 (95% confidence interval 0.97-1.24) for intrapartum cesarean, 1.03 (0.91-1.16) for prelabor cesarean, 0.98 (0.90-1.07) for penicillin, and 0.99 (0.92-1.06) for broader spectrum antibiotics. In a sibling-stratified Cox regression, intrapartum cesarean was associated with increased ADHD risk, but other exposures were not. In a descriptive, nonstratified Cox model, we found increased risk for ADHD for all exposures. CONCLUSIONS: Detailed family confounder control using the superior between-within model indicates that cesarean delivery or use of antibiotics during the first 2 years of life does not increase ADHD risk. Therefore, our study suggests that changes in children's microbiota related to cesarean delivery or antibiotic use, do not cause ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.151-159[article] Investigating the effects of cesarean delivery and antibiotic use in early childhood on risk of later attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / P. B. AXELSSON, Auteur ; T. D. CLAUSEN, Auteur ; A. H. PETERSEN, Auteur ; I. HAGEMAN, Auteur ; A. PINBORG, Auteur ; L. V. KESSING, Auteur ; T. BERGHOLT, Auteur ; S. C. RASMUSSEN, Auteur ; N. KEIDING, Auteur ; E. C. L. LOKKEGAARD, Auteur . - p.151-159.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.151-159
Mots-clés : Attention deficit hyperactivity disorder antibiotics cesarean section microbiota sibling relations Index. décimale : PER Périodiques Résumé : BACKGROUND: Increasing attention deficit hyperactivity disorder (ADHD) incidence has been proposed to be caused by factors influencing microbiota in early life. We investigated the potential causality between ADHD and two surrogate markers for changes in children's microbiota: birth delivery mode and early childhood antibiotic use. METHOD: This population-based, prospective cohort study linked nationwide registers of data for native Danish singleton live births in Denmark from 1997 to 2010. Exposure variables were delivery mode and antibiotic use during the first 2 years of life. The main outcome measure was ADHD diagnosis or redeemed ADHD medication prescriptions. For statistical analysis, we used both advanced sibling models and a more traditional approach. RESULTS: We included 671,592 children, followed from their second birthday in the period 1999-2014 for 7,300,522 person-years. ADHD was diagnosed in 17,971. In total, 17.5% were born by cesarean delivery, and 72% received antibiotic treatment within their first 2 years of life. In the adjusted between-within sibling survival model, mode of delivery or antibiotics had no effect on ADHD when compared with vaginal delivery or no antibiotic treatment as hazard ratios were 1.09 (95% confidence interval 0.97-1.24) for intrapartum cesarean, 1.03 (0.91-1.16) for prelabor cesarean, 0.98 (0.90-1.07) for penicillin, and 0.99 (0.92-1.06) for broader spectrum antibiotics. In a sibling-stratified Cox regression, intrapartum cesarean was associated with increased ADHD risk, but other exposures were not. In a descriptive, nonstratified Cox model, we found increased risk for ADHD for all exposures. CONCLUSIONS: Detailed family confounder control using the superior between-within model indicates that cesarean delivery or use of antibiotics during the first 2 years of life does not increase ADHD risk. Therefore, our study suggests that changes in children's microbiota related to cesarean delivery or antibiotic use, do not cause ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381