Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study / Daniel FATORI in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Titre : Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study Type de document : texte imprimé Auteurs : Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur Article en page(s) : p.2457-2467 Langues : Anglais (eng) Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study [texte imprimé] / Daniel FATORI, Auteur ; Elizabeth SHEPHARD, Auteur ; Danilo BENETTE, Auteur ; Nathalia Ferrazzo NASPOLINI, Auteur ; Grover Castro GUZMAN, Auteur ; Jaqueline Yu Ting WANG, Auteur ; Pedro TÓTOLO, Auteur ; Anthonieta Looman MAFRA, Auteur ; Caio ISAIAS, Auteur ; Davi Pereira DOS SANTOS, Auteur ; Fabiele Baldino RUSSO, Auteur ; Gerson KOBAYASHI, Auteur ; Adriana ARGEU, Auteur ; Monike TEIXEIRA, Auteur ; Ana Claudia MATTIELLO-SVERZUT, Auteur ; Maria Teresa Bechere FERNANDES, Auteur ; Danila Cristina PETIAN-ALONSO, Auteur ; Helena BRENTANI, Auteur ; Marilia SCLIAR, Auteur ; Paulo Alfonso SCHÃœROFF, Auteur ; Pedro ZUCCOLO, Auteur ; Rogério LERNER, Auteur ; Stephania GERALDINI, Auteur ; Veronica Luiza Vale EUCLYDES, Auteur ; Alicia MATIJASEVICH, Auteur ; Alline Cristina DE CAMPOS, Auteur ; André Carlos Ponce DE CARVALHO, Auteur ; André FUJITA, Auteur ; Carla R. TADDEI, Auteur ; Maria Rita PASSOS-BUENO, Auteur ; Patricia BELTRÃO-BRAGA, Auteur ; Guilherme Vanoni POLANCZYK, Auteur . - p.2457-2467. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2457-2467 Mots-clés : child development  cohort study  electroencephalography  genetics  gut microbiome Index. décimale : PER Périodiques Résumé : This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. En ligne : https://dx.doi.org/10.1017/S0954579425000069 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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