Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda / Rebecca GRZADZINSKI in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda Type de document : texte imprimé Auteurs : Rebecca GRZADZINSKI, Auteur ; Dima AMSO, Auteur ; Rebecca LANDA, Auteur ; Linda WATSON, Auteur ; Michael GURALNICK, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Gedeon DEÁK, Auteur ; Annette ESTES, Auteur ; Jessica BRIAN, Auteur ; Kevin BATH, Auteur ; Jed ELISON, Auteur ; Leonard ABBEDUTO, Auteur ; Jason WOLFF, Auteur ; Joseph PIVEN, Auteur Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/therapy  Behavior Therapy  Humans  Infant  Social Behavior Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) impacts an individual's ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD). En ligne : https://dx.doi.org/10.1186/s11689-021-09393-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda [texte imprimé] / Rebecca GRZADZINSKI, Auteur ; Dima AMSO, Auteur ; Rebecca LANDA, Auteur ; Linda WATSON, Auteur ; Michael GURALNICK, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Gedeon DEÁK, Auteur ; Annette ESTES, Auteur ; Jessica BRIAN, Auteur ; Kevin BATH, Auteur ; Jed ELISON, Auteur ; Leonard ABBEDUTO, Auteur ; Jason WOLFF, Auteur ; Joseph PIVEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Autism Spectrum Disorder/diagnosis/therapy  Behavior Therapy  Humans  Infant  Social Behavior Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) impacts an individual's ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD). En ligne : https://dx.doi.org/10.1186/s11689-021-09393-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life / Emma R. COCO in Journal of Autism and Developmental Disorders, 55-12 (December 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4439-4449 Titre : Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life Type de document : texte imprimé Auteurs : Emma R. COCO, Auteur ; Jeffrey MUNSON, Auteur ; Tanya ST JOHN, Auteur ; Stephen R. DAGER, Auteur ; Kelly BOTTERON, Auteur ; Jed ELISON, Auteur ; Dea GARIC, Auteur ; Heather HAZLETT, Auteur ; Chimei LEE, Auteur ; Natasha MARRUS, Auteur ; John R. PRUETT, Auteur ; Robert SCHULTZ, Auteur ; Mark SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Annette ESTES, Auteur Article en page(s) : p.4439-4449 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sleep problems have been associated with atypical development, but there is limited understanding of when sleep problems arise and how they differ across clinical populations. We aimed to evaluate sleep characteristics of infants with Down syndrome (DS), higher familial likelihood of autism (HL) and lower familial likelihood of autism (LL) at 6 and 12 months of age. Participants were from two longitudinal, multi-site, studies. Sleep was estimated by parent report on the Brief Infant Sleep Questionnaire at 6 months (59 DS, 173 HL, 54 LL); 12 months (58 DS, 129 HL, 30 LL); and in a longitudinal subset at both 6 and 12 months (100 HL; 23 LL; 33 DS). At 6-months, DS parents reported less concern about infant sleep and less night wakefulness than LL parents; HL parents reported longer sleep onset latency (SOL). At 12 months DS parents reported less night sleep and more night wakefulness; HL parents reported less night sleep, more night wakefulness and longer SOL compared to LL. Night wakefulness increased significantly in the DS and HL groups from 6 to 12 months of age. A higher proportion of DS and HL infants decreased Night Sleep and increased Night Wakefulness compared with the LL group. A higher proportion of DS infants increased SOL compared with the LL group. Sleep alterations are present in the first year of life and may differ in DS and HL infants. The mechanisms behind these sleep alterations may be an important early intervention target. En ligne : https://doi.org/10.1007/s10803-025-06927-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life [texte imprimé] / Emma R. COCO, Auteur ; Jeffrey MUNSON, Auteur ; Tanya ST JOHN, Auteur ; Stephen R. DAGER, Auteur ; Kelly BOTTERON, Auteur ; Jed ELISON, Auteur ; Dea GARIC, Auteur ; Heather HAZLETT, Auteur ; Chimei LEE, Auteur ; Natasha MARRUS, Auteur ; John R. PRUETT, Auteur ; Robert SCHULTZ, Auteur ; Mark SHEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Joseph PIVEN, Auteur ; Annette ESTES, Auteur . - p.4439-4449. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-12 (December 2025) . - p.4439-4449 Index. décimale : PER Périodiques Résumé : Sleep problems have been associated with atypical development, but there is limited understanding of when sleep problems arise and how they differ across clinical populations. We aimed to evaluate sleep characteristics of infants with Down syndrome (DS), higher familial likelihood of autism (HL) and lower familial likelihood of autism (LL) at 6 and 12 months of age. Participants were from two longitudinal, multi-site, studies. Sleep was estimated by parent report on the Brief Infant Sleep Questionnaire at 6 months (59 DS, 173 HL, 54 LL); 12 months (58 DS, 129 HL, 30 LL); and in a longitudinal subset at both 6 and 12 months (100 HL; 23 LL; 33 DS). At 6-months, DS parents reported less concern about infant sleep and less night wakefulness than LL parents; HL parents reported longer sleep onset latency (SOL). At 12 months DS parents reported less night sleep and more night wakefulness; HL parents reported less night sleep, more night wakefulness and longer SOL compared to LL. Night wakefulness increased significantly in the DS and HL groups from 6 to 12 months of age. A higher proportion of DS and HL infants decreased Night Sleep and increased Night Wakefulness compared with the LL group. A higher proportion of DS infants increased SOL compared with the LL group. Sleep alterations are present in the first year of life and may differ in DS and HL infants. The mechanisms behind these sleep alterations may be an important early intervention target. En ligne : https://doi.org/10.1007/s10803-025-06927-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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