Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder / Kenneth D. GADOW in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1331-1338 Titre : Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur Année de publication : 2008 Article en page(s) : p.1331-1338 Langues : Anglais (eng) Mots-clés : Autism Asperger's-syndrome PDD-NOS autism-spectrum-disorder attention-deficit/hyperactivity-disorder impulsivity social-anxiety dopamine dopamine-transporter-gene genetics Tourette-syndrome Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the 3'-untranslated region of the dopamine transporter gene (DAT1) and the severity of these symptoms as well as the association between the DAT1 DdeI polymorphism and severity of tics. Methods: Parents (n = 62) and teachers (n = 57) completed a DSM-IV-referenced rating scale for 67 children with ASD. Results: According to parent ratings, children with the 10-10 repeat allele (versus a combined group of all other genotypes) exhibited less severe symptoms of hyperactivity and impulsivity as well as less severe language deficits. Teacher ratings indicated that social anxiety and tic symptoms were more severe for children with the 10-10 genotype versus all others. Exploratory analyses provided preliminary support for the notion that heterozygosity (9–10 repeat genotype) may be a risk/protective factor. There were no associations of tic severity with the DAT1 DdeI polymorphism. Conclusion: Collectively, these results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations. Nevertheless, replication with independent samples is necessary to confirm this preliminary finding. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01952.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645 [article] Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur . - 2008 . - p.1331-1338. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1331-1338 Mots-clés : Autism Asperger's-syndrome PDD-NOS autism-spectrum-disorder attention-deficit/hyperactivity-disorder impulsivity social-anxiety dopamine dopamine-transporter-gene genetics Tourette-syndrome Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is associated with high rates of psychiatric disturbance to include attention-deficit/hyperactivity disorder (ADHD), tic disorder, and anxiety disorders. The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism located in the 3'-untranslated region of the dopamine transporter gene (DAT1) and the severity of these symptoms as well as the association between the DAT1 DdeI polymorphism and severity of tics. Methods: Parents (n = 62) and teachers (n = 57) completed a DSM-IV-referenced rating scale for 67 children with ASD. Results: According to parent ratings, children with the 10-10 repeat allele (versus a combined group of all other genotypes) exhibited less severe symptoms of hyperactivity and impulsivity as well as less severe language deficits. Teacher ratings indicated that social anxiety and tic symptoms were more severe for children with the 10-10 genotype versus all others. Exploratory analyses provided preliminary support for the notion that heterozygosity (9–10 repeat genotype) may be a risk/protective factor. There were no associations of tic severity with the DAT1 DdeI polymorphism. Conclusion: Collectively, these results suggest that the extraordinary variability in ASD clinical phenotypes may be explained in part by the same genes that are implicated in a host of other psychiatric disorders in non-ASD populations. Nevertheless, replication with independent samples is necessary to confirm this preliminary finding. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01952.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645

Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder / Kenneth D. GADOW in Journal of Autism and Developmental Disorders, 39-11 (November 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551 Titre : Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur Année de publication : 2009 Article en page(s) : p.1542-1551 Langues : Anglais (eng) Mots-clés : Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1 Index. décimale : PER Périodiques Résumé : The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. En ligne : http://dx.doi.org/10.1007/s10803-009-0794-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849 [article] Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur . - 2009 . - p.1542-1551. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-11 (November 2009) . - p.1542-1551 Mots-clés : Autism Autism-spectrum-disorder Anxiety Attention-deficit-hyperactivity-disorder Tourette-syndrome BDNF COMT DAT1 Index. décimale : PER Périodiques Résumé : The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp 2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. En ligne : http://dx.doi.org/10.1007/s10803-009-0794-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=849

Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder / Jasmin ROOHI in Journal of Autism and Developmental Disorders, 39-1 (January 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.67-74 Titre : Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jasmin ROOHI, Auteur ; Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Eli HATCHWELL, Auteur Année de publication : 2009 Article en page(s) : p.67-74 Langues : Anglais (eng) Mots-clés : Autism Asperger’s-syndrome PDD-NOS Autism-spectrum-disorder Attention-deficit/hyperactivity-disorder Generalized-anxiety-disorder Monoamine-oxidase MAO-A Genetics Index. décimale : PER Périodiques Résumé : The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding. En ligne : http://dx.doi.org/10.1007/s10803-008-0600-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 [article] Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jasmin ROOHI, Auteur ; Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Eli HATCHWELL, Auteur . - 2009 . - p.67-74. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.67-74 Mots-clés : Autism Asperger’s-syndrome PDD-NOS Autism-spectrum-disorder Attention-deficit/hyperactivity-disorder Generalized-anxiety-disorder Monoamine-oxidase MAO-A Genetics Index. décimale : PER Périodiques Résumé : The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding. En ligne : http://dx.doi.org/10.1007/s10803-008-0600-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660

Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder / Kenneth D. GADOW in Journal of Autism and Developmental Disorders, 40-9 (September 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1139-1145 Titre : Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur Année de publication : 2010 Article en page(s) : p.1139-1145 Langues : Anglais (eng) Mots-clés : Autism Autism-spectrum-disorder SLC1A1 Obsessive–compulsive-behaviors Separation-anxiety Generalized-anxiety Index. décimale : PER Périodiques Résumé : Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples. En ligne : http://dx.doi.org/10.1007/s10803-010-0961-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Carla DEVINCENT, Auteur ; Jasmin ROOHI, Auteur ; Eli HATCHWELL, Auteur ; Sarah KIRSCH, Auteur . - 2010 . - p.1139-1145. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1139-1145 Mots-clés : Autism Autism-spectrum-disorder SLC1A1 Obsessive–compulsive-behaviors Separation-anxiety Generalized-anxiety Index. décimale : PER Périodiques Résumé : Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples. En ligne : http://dx.doi.org/10.1007/s10803-010-0961-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

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