Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China / Dizhou PANG in Autism Research, 19-6 (June 2026)  

Public ISBD [article]  inAutism Research > 19-6 (June 2026) . - p.e70253 Titre : Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China Type de document : texte imprimé Auteurs : Dizhou PANG, Auteur ; Guiqin DUAN, Auteur ; Qing SHANG, Auteur ; Huichun ZHANG, Auteur ; Binbin WANG, Auteur ; Huaili DING, Auteur ; Huihui KANG, Auteur ; Yue ZHAO, Auteur ; Yuxia LU, Auteur ; Gai TIAN, Auteur ; Li ZHANG, Auteur ; Wu JIANG, Auteur ; Ganyu WANG, Auteur ; Cailing LIANG, Auteur ; Lingling ZHANG, Auteur ; Bingbing LI, Auteur ; Zhenghua LI, Auteur ; Chunlan SONG, Auteur ; Yanyan YANG, Auteur ; Yazhe WANG, Auteur ; Kaichen YUE, Auteur ; Yongbin LANG, Auteur ; Jiatian LIU, Auteur ; Xiaoli ZHANG, Auteur ; Yiran XU, Auteur ; Changlian ZHU, Auteur Article en page(s) : p.e70253 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  childhood autism rating scale  comorbidities  disease severity  Gesell developmental schedule  intellectual developmental disorders  Wechsler intelligence scales Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently present with co-occurring conditions that can influence autism symptom severity and complicate clinical management. However, studies with clinician-confirmed diagnoses in non-Western populations remain limited. In this multicenter cross-sectional study, 1279 children aged 3?14?years with DSM-5-confirmed ASD were recruited from eight medical centers in China. Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS). Comorbidities were identified through clinical evaluation and specialized assessments, and developmental status was measured using the Gesell Developmental Schedule (GDS) and Wechsler Intelligence Scales. Associations with CARS scores were analyzed using generalized linear regression. Of participants, 96.6% had at least one comorbidity and 71.2% had multiple comorbidities. Common conditions were intellectual developmental disorders (IDD) (87.3%), food selectivity (45.3%), insomnia disorder (16.9%), developmental regression (15.6%), and behavioral problems (14.6%). Patterns differed by sex and age: gastrointestinal problem and sleep-related interventions were more common in girls, whereas food selectivity was more common in boys. Older children showed higher rates of tic disorders, asthma, epilepsy, and offensive language, although these findings should be interpreted cautiously because the subgroup aged ≥?6?years was small. In adjusted analyses, IDD, food selectivity, pica, insomnia disorder, and developmental regression were associated with higher CARS scores, whereas higher GDS and Wechsler scores were associated with lower CARS scores. In this Chinese cohort, comorbidities were prevalent and showed distinct sex- and age-related patterns. Several comorbidities were associated with greater autism symptom severity, underscoring the importance of comprehensive developmental and medical assessment in ASD care. En ligne : https://doi.org/10.1002/aur.70253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross-Sectional Study in China [texte imprimé] / Dizhou PANG, Auteur ; Guiqin DUAN, Auteur ; Qing SHANG, Auteur ; Huichun ZHANG, Auteur ; Binbin WANG, Auteur ; Huaili DING, Auteur ; Huihui KANG, Auteur ; Yue ZHAO, Auteur ; Yuxia LU, Auteur ; Gai TIAN, Auteur ; Li ZHANG, Auteur ; Wu JIANG, Auteur ; Ganyu WANG, Auteur ; Cailing LIANG, Auteur ; Lingling ZHANG, Auteur ; Bingbing LI, Auteur ; Zhenghua LI, Auteur ; Chunlan SONG, Auteur ; Yanyan YANG, Auteur ; Yazhe WANG, Auteur ; Kaichen YUE, Auteur ; Yongbin LANG, Auteur ; Jiatian LIU, Auteur ; Xiaoli ZHANG, Auteur ; Yiran XU, Auteur ; Changlian ZHU, Auteur . - p.e70253. Langues : Anglais (eng) in Autism Research > 19-6 (June 2026) . - p.e70253 Mots-clés : autism spectrum disorder  childhood autism rating scale  comorbidities  disease severity  Gesell developmental schedule  intellectual developmental disorders  Wechsler intelligence scales Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently present with co-occurring conditions that can influence autism symptom severity and complicate clinical management. However, studies with clinician-confirmed diagnoses in non-Western populations remain limited. In this multicenter cross-sectional study, 1279 children aged 3?14?years with DSM-5-confirmed ASD were recruited from eight medical centers in China. Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS). Comorbidities were identified through clinical evaluation and specialized assessments, and developmental status was measured using the Gesell Developmental Schedule (GDS) and Wechsler Intelligence Scales. Associations with CARS scores were analyzed using generalized linear regression. Of participants, 96.6% had at least one comorbidity and 71.2% had multiple comorbidities. Common conditions were intellectual developmental disorders (IDD) (87.3%), food selectivity (45.3%), insomnia disorder (16.9%), developmental regression (15.6%), and behavioral problems (14.6%). Patterns differed by sex and age: gastrointestinal problem and sleep-related interventions were more common in girls, whereas food selectivity was more common in boys. Older children showed higher rates of tic disorders, asthma, epilepsy, and offensive language, although these findings should be interpreted cautiously because the subgroup aged ≥?6?years was small. In adjusted analyses, IDD, food selectivity, pica, insomnia disorder, and developmental regression were associated with higher CARS scores, whereas higher GDS and Wechsler scores were associated with lower CARS scores. In this Chinese cohort, comorbidities were prevalent and showed distinct sex- and age-related patterns. Several comorbidities were associated with greater autism symptom severity, underscoring the importance of comprehensive developmental and medical assessment in ASD care. En ligne : https://doi.org/10.1002/aur.70253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Clinical characteristics and long-term neurodevelopmental outcomes of leukomalacia in preterm infants and term infants: a cohort study / Juan SONG in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Clinical characteristics and long-term neurodevelopmental outcomes of leukomalacia in preterm infants and term infants: a cohort study Type de document : texte imprimé Auteurs : Juan SONG, Auteur ; Yuyang YUE, Auteur ; Huiqing SUN, Auteur ; Ping CHENG, Auteur ; Falin XU, Auteur ; Bingbing LI, Auteur ; Kenan LI, Auteur ; Changlian ZHU, Auteur Langues : Anglais (eng) Mots-clés : Infant, Newborn  Infant  Humans  Child, Preschool  Child  Infant, Premature  Cohort Studies  Leukomalacia, Periventricular/complications/epidemiology/diagnosis  Cerebral Palsy/diagnosis/pathology  Epilepsy  Cerebral palsy  Head MRI  Leukomalacia  Neurodevelopmental outcomes  Newborn Index. décimale : PER Périodiques Résumé : BACKGROUND: Leukomalacia is a serious form of neonatal brain injury that often leads to neurodevelopmental impairment, and studies on neonatal leukomalacia and its long-term outcomes are lacking. The aim of this study was to analyze the clinical manifestations, imaging features, and long-term neurodevelopmental outcomes in preterm infants and term infants with leukomalacia. METHODS: Newborns diagnosed with leukomalacia by head magnetic resonance imaging (MRI) and who were admitted to intensive care units from January 2015 to June 2020 were enrolled. All infants were followed up to June 2022 (2-7 years old), and their neurodevelopmental outcomes were evaluated. The clinical data and long- term outcomes of preterm infants and term infants was analyzed by Chi-square tests. RESULTS: A total of 218 surviving infants with leukomalacia including 114 preterm infants and 104 term infants completed the follow-up. The major typesof leukomalacia on MRI were periventricular leukomalacia in the preterm group and subcortical cystic leukomalacia in the term group, respectively (χ(2) = 55.166; p < 0.001). When followed up to 2-7 years old, the incidence of neurodevelopmental impairment in the preterm group and term group was not significantly different (χ(2) = 0.917; p = 0.338). However, the incidence of cerebral palsy (CP) in the preterm group was significantly higher (χ(2) = 4.896; p = 0.027), while the incidence of intellectual disability (ID) (χ(2) = 9.445; p = 0.002), epilepsy (EP) (χ(2) = 23.049; p < 0.001), and CP combined with ID andEP (χ(2) = 4.122; p = 0.042) was significantly lower than that in the term group. CONCLUSIONS: Periventricular leukomalacia mainly occurred in preterm infants while subcortical cystic leukomalacia was commonly seen in term infants. Although the long-term neurodevelopmental outcomes of leukomalacia were both poor, preterm infants were more prone to CP, while term infants were more prone to ID, EP, and the combination of CP with ID and EP. En ligne : https://dx.doi.org/10.1186/s11689-023-09489-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Clinical characteristics and long-term neurodevelopmental outcomes of leukomalacia in preterm infants and term infants: a cohort study [texte imprimé] / Juan SONG, Auteur ; Yuyang YUE, Auteur ; Huiqing SUN, Auteur ; Ping CHENG, Auteur ; Falin XU, Auteur ; Bingbing LI, Auteur ; Kenan LI, Auteur ; Changlian ZHU, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Infant, Newborn  Infant  Humans  Child, Preschool  Child  Infant, Premature  Cohort Studies  Leukomalacia, Periventricular/complications/epidemiology/diagnosis  Cerebral Palsy/diagnosis/pathology  Epilepsy  Cerebral palsy  Head MRI  Leukomalacia  Neurodevelopmental outcomes  Newborn Index. décimale : PER Périodiques Résumé : BACKGROUND: Leukomalacia is a serious form of neonatal brain injury that often leads to neurodevelopmental impairment, and studies on neonatal leukomalacia and its long-term outcomes are lacking. The aim of this study was to analyze the clinical manifestations, imaging features, and long-term neurodevelopmental outcomes in preterm infants and term infants with leukomalacia. METHODS: Newborns diagnosed with leukomalacia by head magnetic resonance imaging (MRI) and who were admitted to intensive care units from January 2015 to June 2020 were enrolled. All infants were followed up to June 2022 (2-7 years old), and their neurodevelopmental outcomes were evaluated. The clinical data and long- term outcomes of preterm infants and term infants was analyzed by Chi-square tests. RESULTS: A total of 218 surviving infants with leukomalacia including 114 preterm infants and 104 term infants completed the follow-up. The major typesof leukomalacia on MRI were periventricular leukomalacia in the preterm group and subcortical cystic leukomalacia in the term group, respectively (χ(2) = 55.166; p < 0.001). When followed up to 2-7 years old, the incidence of neurodevelopmental impairment in the preterm group and term group was not significantly different (χ(2) = 0.917; p = 0.338). However, the incidence of cerebral palsy (CP) in the preterm group was significantly higher (χ(2) = 4.896; p = 0.027), while the incidence of intellectual disability (ID) (χ(2) = 9.445; p = 0.002), epilepsy (EP) (χ(2) = 23.049; p < 0.001), and CP combined with ID andEP (χ(2) = 4.122; p = 0.042) was significantly lower than that in the term group. CONCLUSIONS: Periventricular leukomalacia mainly occurred in preterm infants while subcortical cystic leukomalacia was commonly seen in term infants. Although the long-term neurodevelopmental outcomes of leukomalacia were both poor, preterm infants were more prone to CP, while term infants were more prone to ID, EP, and the combination of CP with ID and EP. En ligne : https://dx.doi.org/10.1186/s11689-023-09489-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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