[article]
| Titre : |
A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems |
| Type de document : |
texte imprimé |
| Auteurs : |
Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Emotional regulation Functional MRI connectivity Multimodal neuroimaging Neurodevelopment Resilience Sensory over-responsivity Sensory processing disorder involving behavioral and neuroimaging data collection of human participants between ages 8–12 years old was approved by the UCSF institutional review board. Written informed consent from the parent or caregiver and assent from the participant were collected. Consent for publication: All authors have provided approval of the manuscript. This work was made publicly available as a preprint uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1 prior to publishing. It has not been published elsewhere. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09656-y |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
in Journal of Neurodevelopmental Disorders > 17 (2025)
[article] A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems [texte imprimé] / Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 17 (2025)
| Mots-clés : |
Emotional regulation Functional MRI connectivity Multimodal neuroimaging Neurodevelopment Resilience Sensory over-responsivity Sensory processing disorder involving behavioral and neuroimaging data collection of human participants between ages 8–12 years old was approved by the UCSF institutional review board. Written informed consent from the parent or caregiver and assent from the participant were collected. Consent for publication: All authors have provided approval of the manuscript. This work was made publicly available as a preprint uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1 prior to publishing. It has not been published elsewhere. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09656-y |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
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