Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses / Sara CACCIATO-SALCEDO in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70275 Titre : Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses Type de document : texte imprimé Auteurs : Sara CACCIATO-SALCEDO, Auteur ; Shreya JAOKAR, Auteur ; Neil J. INGHAM, Auteur ; Manuel S. MALMIERCA, Auteur ; Marija M. PETRINOVIC, Auteur Article en page(s) : p.e70275 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  electroencephalography (EEG)  magnetoencephalography (MEG)  mismatch fields (MMF)  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory mismatch responses?mismatch negativity (MMN) and mismatch fields (MMF)?are well established electrophysiological markers of automatic auditory discrimination supported by short-term sensory memory. These responses, typically elicited using passive oddball paradigms, are increasingly used to investigate sensory and language processing in autism. This systematic review synthesizes findings from 55 studies comparing MMN and MMF responses in autistic and typically developing (TD) individuals across childhood, adolescence, and adulthood. Using the Synthesis Without Meta-analysis (SWiM) framework, we identified consistent evidence for smaller MMN amplitudes and reduced MMF power in autistic children and adolescents relative to TD peers, particularly in response to frequency, duration, and speech-based deviants. Studies also frequently reported longer mismatch latencies in autistic participants and associated these delays with language difficulties and heightened auditory sensitivity. Although some studies reported age-related convergence in MMN and MMF measures between autistic and TD groups in later childhood or adolescence, greater right-hemisphere lateralization in autistic individuals emerged as a consistent finding across both speech and non-speech paradigms, suggesting differences in hemispheric weighting for auditory processing of linguistic and non-linguistic cues. To explain interindividual and developmental variability in mismatch responses, we propose a precision-weighted predictive coding account, in which divergent assignment of confidence to sensory prediction errors may contribute to autism-related differences. While study quality was generally fair, methodological heterogeneity, underrepresentation of females, and limited cross-cultural sampling constrain generalizability. Future research should prioritize longitudinal, sex-stratified, and culturally diverse designs, using standardized protocols and collaborative data practices. MMN and MMF responses hold promise as non-invasive translational biomarkers of early-stage sensory prediction and neurodevelopmental variation in autism. En ligne : https://doi.org/10.1002/aur.70275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses [texte imprimé] / Sara CACCIATO-SALCEDO, Auteur ; Shreya JAOKAR, Auteur ; Neil J. INGHAM, Auteur ; Manuel S. MALMIERCA, Auteur ; Marija M. PETRINOVIC, Auteur . - p.e70275. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70275 Mots-clés : autism spectrum disorder (ASD)  electroencephalography (EEG)  magnetoencephalography (MEG)  mismatch fields (MMF)  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory mismatch responses?mismatch negativity (MMN) and mismatch fields (MMF)?are well established electrophysiological markers of automatic auditory discrimination supported by short-term sensory memory. These responses, typically elicited using passive oddball paradigms, are increasingly used to investigate sensory and language processing in autism. This systematic review synthesizes findings from 55 studies comparing MMN and MMF responses in autistic and typically developing (TD) individuals across childhood, adolescence, and adulthood. Using the Synthesis Without Meta-analysis (SWiM) framework, we identified consistent evidence for smaller MMN amplitudes and reduced MMF power in autistic children and adolescents relative to TD peers, particularly in response to frequency, duration, and speech-based deviants. Studies also frequently reported longer mismatch latencies in autistic participants and associated these delays with language difficulties and heightened auditory sensitivity. Although some studies reported age-related convergence in MMN and MMF measures between autistic and TD groups in later childhood or adolescence, greater right-hemisphere lateralization in autistic individuals emerged as a consistent finding across both speech and non-speech paradigms, suggesting differences in hemispheric weighting for auditory processing of linguistic and non-linguistic cues. To explain interindividual and developmental variability in mismatch responses, we propose a precision-weighted predictive coding account, in which divergent assignment of confidence to sensory prediction errors may contribute to autism-related differences. While study quality was generally fair, methodological heterogeneity, underrepresentation of females, and limited cross-cultural sampling constrain generalizability. Future research should prioritize longitudinal, sex-stratified, and culturally diverse designs, using standardized protocols and collaborative data practices. MMN and MMF responses hold promise as non-invasive translational biomarkers of early-stage sensory prediction and neurodevelopmental variation in autism. En ligne : https://doi.org/10.1002/aur.70275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function / Sara CACCIATO-SALCEDO in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2382-2408 Titre : Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function Type de document : texte imprimé Auteurs : Sara CACCIATO-SALCEDO, Auteur ; Ana B. LAO-RODRÍGUEZ, Auteur ; Manuel S. MALMIERCA, Auteur Article en page(s) : p.2382-2408 Langues : Anglais (eng) Mots-clés : ABR  auditory  auditory phenotypes  autism  Grin2b gene  sex  valproic acid Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is an early-onset neurodevelopmental disorder characterized by restricted, repetitive behaviors and atypical patterns of social communication and interaction. A considerable proportion of autistic individuals experience divergent auditory perception, which can interfere with their ability to navigate everyday sound environments. Auditory brainstem responses are electrophysiological potentials elicited by auditory stimuli that evaluate neural activity along the auditory nerve and brainstem. Importantly, the auditory brainstem response varies by sex, with females typically showing higher amplitudes and shorter latencies than males. This sex-specific neurophysiological profile is especially relevant in autism research, where the male-to-female diagnosis ratio is approximately 3:1. Thus, exploring the neurobiological mechanisms underlying sex-specific variations in autistic traits is essential. Furthermore, autism sensory profiles may vary based on the independent and mutual effects of environmental and genetic factors. To deepen this understanding, we examined auditory brainstem responses in two rat models of autism: the GRIN2B rare mutation model and the prenatal valproic acid induction model, alongside control animals. We assessed peak amplitudes and latencies (Waves I through V), inter-peak intervals (I?III, I?V, and III?V), and amplitude ratios (III:I, V:I, and V:III). Female rats generally exhibited greater amplitudes and longer latencies across waveforms. Regarding rat models, control animals consistently showed larger amplitudes and shorter latencies compared to autism-like models. Exploratory analyses further suggested pairwise interactions between sex and rat model, indicating modulation of auditory phenotypes linked to autism. Thus, our findings reveal key insights into the effects of sex and rat model, as well as their interactions. En ligne : https://doi.org/10.1002/aur.70125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function [texte imprimé] / Sara CACCIATO-SALCEDO, Auteur ; Ana B. LAO-RODRÍGUEZ, Auteur ; Manuel S. MALMIERCA, Auteur . - p.2382-2408. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2382-2408 Mots-clés : ABR  auditory  auditory phenotypes  autism  Grin2b gene  sex  valproic acid Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is an early-onset neurodevelopmental disorder characterized by restricted, repetitive behaviors and atypical patterns of social communication and interaction. A considerable proportion of autistic individuals experience divergent auditory perception, which can interfere with their ability to navigate everyday sound environments. Auditory brainstem responses are electrophysiological potentials elicited by auditory stimuli that evaluate neural activity along the auditory nerve and brainstem. Importantly, the auditory brainstem response varies by sex, with females typically showing higher amplitudes and shorter latencies than males. This sex-specific neurophysiological profile is especially relevant in autism research, where the male-to-female diagnosis ratio is approximately 3:1. Thus, exploring the neurobiological mechanisms underlying sex-specific variations in autistic traits is essential. Furthermore, autism sensory profiles may vary based on the independent and mutual effects of environmental and genetic factors. To deepen this understanding, we examined auditory brainstem responses in two rat models of autism: the GRIN2B rare mutation model and the prenatal valproic acid induction model, alongside control animals. We assessed peak amplitudes and latencies (Waves I through V), inter-peak intervals (I?III, I?V, and III?V), and amplitude ratios (III:I, V:I, and V:III). Female rats generally exhibited greater amplitudes and longer latencies across waveforms. Regarding rat models, control animals consistently showed larger amplitudes and shorter latencies compared to autism-like models. Exploratory analyses further suggested pairwise interactions between sex and rat model, indicating modulation of auditory phenotypes linked to autism. Thus, our findings reveal key insights into the effects of sex and rat model, as well as their interactions. En ligne : https://doi.org/10.1002/aur.70125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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