Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives / Shubham DWIVEDI in Research in Autism, 133 (May 2026)  

Public ISBD [article]  inResearch in Autism > 133 (May 2026) . - p.202900 Titre : Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives Type de document : texte imprimé Auteurs : Shubham DWIVEDI, Auteur ; Monica TSCHANG, Auteur ; Amirthavarshini SUBBURAMAN, Auteur ; Sara VARGHESE, Auteur ; Swathi V. REDDY, Auteur ; Shalini SHUKLA, Auteur ; Shikha PANDEY, Auteur ; Priya GUPTA, Auteur ; Priyanka SHARMA, Auteur ; Dharmendra Prasad KEWAT, Auteur ; Deepak KUMAR, Auteur ; Dhruv PATEL, Auteur ; Reshu AGRAWAL, Auteur ; Ramu SINGH, Auteur ; Anglina KISKU, Auteur ; Sri Harshini GOLI, Auteur ; Kunjbihari SULAKHIYA, Auteur ; Suneel KUMAR, Auteur Article en page(s) : p.202900 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Vasopressin  Glutamate  GABA  Brain-derived neurotrophic factor  Genetics  Environmental factors Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by differences in social interaction, communication, and behavior. The etiology of ASD is multifaceted, with genetic, environmental, and epigenetic variables playing important roles. This complex interplay of factors has driven extensive research into the underlying molecular and neurological processes of ASD. As a result of these investigations, researchers have developed a more comprehensive understanding of the disorder’s underlying mechanisms, which has led to the identification of new therapeutic targets. This review discusses new targets, including synaptic plasticity regulators and immune system modulators. Despite significant advancements, several obstacles remain in ASD research, including variability in symptomatology, biomarker unavailability, and the need for individualized therapeutic strategies. The search for effective treatments is further complicated by the lack of robust clinical trials and ethical issues surrounding interventions. Here we discuss challenges in ASD management and propose innovative approaches to overcome them in future ASD research. Applying advanced technology and interdisciplinary expertise to the understanding of the interplay of biological and environmental factors that contribute to ASD will aid in the development of personalized therapies and overall improvement in the quality of life for individuals with ASD. En ligne : https://doi.org/10.1016/j.reia.2026.202900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives [texte imprimé] / Shubham DWIVEDI, Auteur ; Monica TSCHANG, Auteur ; Amirthavarshini SUBBURAMAN, Auteur ; Sara VARGHESE, Auteur ; Swathi V. REDDY, Auteur ; Shalini SHUKLA, Auteur ; Shikha PANDEY, Auteur ; Priya GUPTA, Auteur ; Priyanka SHARMA, Auteur ; Dharmendra Prasad KEWAT, Auteur ; Deepak KUMAR, Auteur ; Dhruv PATEL, Auteur ; Reshu AGRAWAL, Auteur ; Ramu SINGH, Auteur ; Anglina KISKU, Auteur ; Sri Harshini GOLI, Auteur ; Kunjbihari SULAKHIYA, Auteur ; Suneel KUMAR, Auteur . - p.202900. Langues : Anglais (eng) in Research in Autism > 133 (May 2026) . - p.202900 Mots-clés : Autism spectrum disorder  Vasopressin  Glutamate  GABA  Brain-derived neurotrophic factor  Genetics  Environmental factors Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by differences in social interaction, communication, and behavior. The etiology of ASD is multifaceted, with genetic, environmental, and epigenetic variables playing important roles. This complex interplay of factors has driven extensive research into the underlying molecular and neurological processes of ASD. As a result of these investigations, researchers have developed a more comprehensive understanding of the disorder’s underlying mechanisms, which has led to the identification of new therapeutic targets. This review discusses new targets, including synaptic plasticity regulators and immune system modulators. Despite significant advancements, several obstacles remain in ASD research, including variability in symptomatology, biomarker unavailability, and the need for individualized therapeutic strategies. The search for effective treatments is further complicated by the lack of robust clinical trials and ethical issues surrounding interventions. Here we discuss challenges in ASD management and propose innovative approaches to overcome them in future ASD research. Applying advanced technology and interdisciplinary expertise to the understanding of the interplay of biological and environmental factors that contribute to ASD will aid in the development of personalized therapies and overall improvement in the quality of life for individuals with ASD. En ligne : https://doi.org/10.1016/j.reia.2026.202900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

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