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Détail de l'auteur
Auteur Bradley S. PETERSON |
Documents disponibles écrits par cet auteur (18)
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The neural bases of obsessive–compulsive disorder in children and adults / Tiago V. MAIA in Development and Psychopathology, 20-4 (Fall 2008)
[article]
Titre : The neural bases of obsessive–compulsive disorder in children and adults Type de document : Texte imprimé et/ou numérique Auteurs : Tiago V. MAIA, Auteur ; Bradley S. PETERSON, Auteur ; Rebecca E. COONEY, Auteur Année de publication : 2008 Article en page(s) : p.1251-1283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Functional imaging studies have reported with remarkable consistency hyperactivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and caudate nucleus of patients with obsessive–compulsive disorder (OCD). These findings have often been interpreted as evidence that abnormalities in cortico–basal ganglia–thalamo–cortical loops involving the OFC and ACC are causally related to OCD. This interpretation remains controversial, however, because such hyperactivity may represent either a cause or a consequence of the symptoms. This article analyzes the evidence for a causal role of these loops in producing OCD in children and adults. The article first reviews the strong evidence for anatomical abnormalities in these loops in patients with OCD. These findings are not sufficient to establish causality, however, because anatomical alterations may themselves be a consequence rather than a cause of the symptoms. The article then reviews three lines of evidence that, despite their own limitations, permit stronger causal inferences: the development of OCD following brain injury, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, and neurosurgical lesions that attenuate OCD. Converging evidence from these various lines of research supports a causal role for the cortico–basal ganglia–thalamo–cortical loops that involve the OFC and ACC in the pathogenesis of OCD in children and adults. En ligne : http://dx.doi.org/10.1017/s0954579408000606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602
in Development and Psychopathology > 20-4 (Fall 2008) . - p.1251-1283[article] The neural bases of obsessive–compulsive disorder in children and adults [Texte imprimé et/ou numérique] / Tiago V. MAIA, Auteur ; Bradley S. PETERSON, Auteur ; Rebecca E. COONEY, Auteur . - 2008 . - p.1251-1283.
Langues : Anglais (eng)
in Development and Psychopathology > 20-4 (Fall 2008) . - p.1251-1283
Index. décimale : PER Périodiques Résumé : Functional imaging studies have reported with remarkable consistency hyperactivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and caudate nucleus of patients with obsessive–compulsive disorder (OCD). These findings have often been interpreted as evidence that abnormalities in cortico–basal ganglia–thalamo–cortical loops involving the OFC and ACC are causally related to OCD. This interpretation remains controversial, however, because such hyperactivity may represent either a cause or a consequence of the symptoms. This article analyzes the evidence for a causal role of these loops in producing OCD in children and adults. The article first reviews the strong evidence for anatomical abnormalities in these loops in patients with OCD. These findings are not sufficient to establish causality, however, because anatomical alterations may themselves be a consequence rather than a cause of the symptoms. The article then reviews three lines of evidence that, despite their own limitations, permit stronger causal inferences: the development of OCD following brain injury, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, and neurosurgical lesions that attenuate OCD. Converging evidence from these various lines of research supports a causal role for the cortico–basal ganglia–thalamo–cortical loops that involve the OFC and ACC in the pathogenesis of OCD in children and adults. En ligne : http://dx.doi.org/10.1017/s0954579408000606 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602 Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders / Angela TSENG in Journal of Autism and Developmental Disorders, 44-6 (June 2014)
[article]
Titre : Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur Article en page(s) : p.1332-1346 Langues : Anglais (eng) Mots-clés : Circumplex model of affect Valence Arousal Autism spectrum disorders Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346[article] Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur . - p.1332-1346.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346
Mots-clés : Circumplex model of affect Valence Arousal Autism spectrum disorders Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)
[article]
Titre : Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur ; Jiaqi LIU, Auteur ; Louis DANTEC, Auteur ; Courtney NEWMAN, Auteur ; Siddhant SAWARDEKAR, Auteur ; Suzanne GOH, Auteur ; Ravi BANSAL, Auteur Article en page(s) : p.855-870 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/metabolism Brain/metabolism Diffusion Tensor Imaging Humans Magnetic Resonance Imaging White Matter/diagnostic imaging/pathology Autism white matter interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Identifying the brain bases for phenotypic heterogeneity in Autism Spectrum Disorder (ASD) will advance understanding of its pathogenesis and improve its clinical management. METHODS: We compared Diffusion Tensor Imaging (DTI) indices and connectome measures between 77 ASD and 88 Typically Developing (TD) control participants. We also assessed voxel-wise associations of DTI indices with measures of regional cerebral blood flow (rCBF) and N-acetylaspartate (NAA) to understand how tissue microstructure associates with cellular metabolism and neuronal density, respectively. RESULTS: Autism Spectrum Disorder participants had significantly lower fractional anisotropy (FA) and higher diffusivity values in deep white matter tracts, likely representing ether reduced myelination by oligodendrocytes or a reduced density of myelinated axons. Greater abnormalities in these measures and regions were associated with higher ASD symptom scores. Participant age, sex and IQ significantly moderated these group differences. Path analyses showed that reduced NAA levels accounted significantly for higher diffusivity and higher rCBF values in ASD compared with TD participants. CONCLUSIONS: Reduced neuronal density (reduced NAA) likely underlies abnormalities in DTI indices of white matter microstructure in ASD, which in turn are major determinants of elevated blood flow. Together, these findings suggest the presence of reduced axonal density and axonal pathology in ASD white matter. Greater pathology in turn accounts for more severe symptoms, lower intellectual ability, and reduced global efficiency for measures of white matter connectivity in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.855-870[article] Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur ; Jiaqi LIU, Auteur ; Louis DANTEC, Auteur ; Courtney NEWMAN, Auteur ; Siddhant SAWARDEKAR, Auteur ; Suzanne GOH, Auteur ; Ravi BANSAL, Auteur . - p.855-870.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-8 (August 2022) . - p.855-870
Mots-clés : Autism Spectrum Disorder/metabolism Brain/metabolism Diffusion Tensor Imaging Humans Magnetic Resonance Imaging White Matter/diagnostic imaging/pathology Autism white matter interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Identifying the brain bases for phenotypic heterogeneity in Autism Spectrum Disorder (ASD) will advance understanding of its pathogenesis and improve its clinical management. METHODS: We compared Diffusion Tensor Imaging (DTI) indices and connectome measures between 77 ASD and 88 Typically Developing (TD) control participants. We also assessed voxel-wise associations of DTI indices with measures of regional cerebral blood flow (rCBF) and N-acetylaspartate (NAA) to understand how tissue microstructure associates with cellular metabolism and neuronal density, respectively. RESULTS: Autism Spectrum Disorder participants had significantly lower fractional anisotropy (FA) and higher diffusivity values in deep white matter tracts, likely representing ether reduced myelination by oligodendrocytes or a reduced density of myelinated axons. Greater abnormalities in these measures and regions were associated with higher ASD symptom scores. Participant age, sex and IQ significantly moderated these group differences. Path analyses showed that reduced NAA levels accounted significantly for higher diffusivity and higher rCBF values in ASD compared with TD participants. CONCLUSIONS: Reduced neuronal density (reduced NAA) likely underlies abnormalities in DTI indices of white matter microstructure in ASD, which in turn are major determinants of elevated blood flow. Together, these findings suggest the presence of reduced axonal density and axonal pathology in ASD white matter. Greater pathology in turn accounts for more severe symptoms, lower intellectual ability, and reduced global efficiency for measures of white matter connectivity in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486