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Auteur Wen-Che TSAI |
Documents disponibles écrits par cet auteur (14)



Changes in clinical presentation of children with autistic disorder, at an autism clinic in Taiwan from 1987 to 1995 / Wen-Che TSAI in Research in Autism Spectrum Disorders, 7-12 (December 2013)
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Titre : Changes in clinical presentation of children with autistic disorder, at an autism clinic in Taiwan from 1987 to 1995 Type de document : Texte imprimé et/ou numérique Auteurs : Wen-Che TSAI, Auteur ; Wei-Tsuen SOONG, Auteur ; Wei-Chu CHIE, Auteur Article en page(s) : p.1501-1508 Langues : Anglais (eng) Mots-clés : Autistic disorder Child mental health Taiwan Index. décimale : PER Périodiques Résumé : Abstract Autistic disorder was originally viewed as a distinct, rare, and severe childhood mental disorder that caused life-long disability. However, since the late 1990s autistic disorder was found to have a high prevalence rate and to affect children on a spectrum from mild to severe dysfunction. The purpose of this retrospective, descriptive study was to examine changes in the characteristics of patients with autistic disorder in Taiwan from 1987 to 1995. To that end, we examined the characteristics, age at diagnosis, symptoms, and developmental condition of affected children and the educational background of their parents who visited an autism clinic at the children's mental health center of a medical center in Taipei. This clinic was the first, largest, and for many years the only autistic disorder clinic in Taiwan. Across the 9-year study period, we observed trends in decreasing age at first visit, increasing age at assessment, rising maternal educational level, lessening autistic disorder symptomatology, and increasing developmental quotients. These changes may have been due to improved diagnostic criteria, government policy, and healthcare professionals’ and parents’ increased awareness of autistic disorder. Clinical implications and related policy making toward these changes are proposed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Research in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1501-1508[article] Changes in clinical presentation of children with autistic disorder, at an autism clinic in Taiwan from 1987 to 1995 [Texte imprimé et/ou numérique] / Wen-Che TSAI, Auteur ; Wei-Tsuen SOONG, Auteur ; Wei-Chu CHIE, Auteur . - p.1501-1508.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1501-1508
Mots-clés : Autistic disorder Child mental health Taiwan Index. décimale : PER Périodiques Résumé : Abstract Autistic disorder was originally viewed as a distinct, rare, and severe childhood mental disorder that caused life-long disability. However, since the late 1990s autistic disorder was found to have a high prevalence rate and to affect children on a spectrum from mild to severe dysfunction. The purpose of this retrospective, descriptive study was to examine changes in the characteristics of patients with autistic disorder in Taiwan from 1987 to 1995. To that end, we examined the characteristics, age at diagnosis, symptoms, and developmental condition of affected children and the educational background of their parents who visited an autism clinic at the children's mental health center of a medical center in Taipei. This clinic was the first, largest, and for many years the only autistic disorder clinic in Taiwan. Across the 9-year study period, we observed trends in decreasing age at first visit, increasing age at assessment, rising maternal educational level, lessening autistic disorder symptomatology, and increasing developmental quotients. These changes may have been due to improved diagnostic criteria, government policy, and healthcare professionals’ and parents’ increased awareness of autistic disorder. Clinical implications and related policy making toward these changes are proposed. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders / Wei-Hsien CHIEN in Molecular Autism, (August 2013)
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Titre : Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Wei-Hsien CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiao-Mei LIAO, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Yu-Shu HUANG, Auteur ; Wen-Che TSAI, Auteur ; Ho-Min TSAI, Auteur ; Chia-Hsiang CHEN, Auteur Année de publication : 2013 Article en page(s) : 23 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background
We recently reported a terminal deletion of approximately 2.4 Mb at chromosome 8p23.2-pter in a boy with autism. The deleted region contained the DLGAP2 gene that encodes the neuronal post-synaptic density protein, discs, large (Drosophila) homolog-associated protein 2. The study aimed to investigate whether DLGAP2 is genetically associated with autism spectrum disorders (ASD) in general.
Methods
We re-sequenced all the exons of DLGPA2 in 515 patients with ASD and 596 control subjects from Taiwan. We also conducted bioinformatic analysis and family study of variants identified in this study.
Results
We detected nine common single nucleotide polymorphisms (SNPs) and sixteen novel missense rare variants in this sample. We found that AA homozygotes of rs2906569 (minor allele G, alternate allele A) at intron 1 (P = 0.003) and CC homozygotes of rs2301963 (minor allele A, alternate allele C) at exon 3 (P = 0.0003) were significantly over-represented in the patient group compared to the controls. We also found no differences in the combined frequency of rare missense variants between the two groups. Some of these rare variants were predicted to have an impact on the function of DLGAP2 using informatics analysis, and the family study revealed most of the rare missense mutations in patients were inherited from their unaffected parents.
Conclusions
We detected some common and rare genetic variants of DLGAP2 that might have implication in the pathogenesis of ASD, but they alone may not be sufficient to lead to clinical phenotypes. We suggest that further genetic or environmental factors in affected patients may be present and determine the clinical manifestations. Trial registration ClinicalTrial.gov, NCT00494754En ligne : http://dx.doi.org/10.1186/2040-2392-4-26 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Molecular Autism > (August 2013) . - 23 p.[article] Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders [Texte imprimé et/ou numérique] / Wei-Hsien CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Hsiao-Mei LIAO, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Yu-Shu HUANG, Auteur ; Wen-Che TSAI, Auteur ; Ho-Min TSAI, Auteur ; Chia-Hsiang CHEN, Auteur . - 2013 . - 23 p.
Langues : Anglais (eng)
in Molecular Autism > (August 2013) . - 23 p.
Index. décimale : PER Périodiques Résumé : Background
We recently reported a terminal deletion of approximately 2.4 Mb at chromosome 8p23.2-pter in a boy with autism. The deleted region contained the DLGAP2 gene that encodes the neuronal post-synaptic density protein, discs, large (Drosophila) homolog-associated protein 2. The study aimed to investigate whether DLGAP2 is genetically associated with autism spectrum disorders (ASD) in general.
Methods
We re-sequenced all the exons of DLGPA2 in 515 patients with ASD and 596 control subjects from Taiwan. We also conducted bioinformatic analysis and family study of variants identified in this study.
Results
We detected nine common single nucleotide polymorphisms (SNPs) and sixteen novel missense rare variants in this sample. We found that AA homozygotes of rs2906569 (minor allele G, alternate allele A) at intron 1 (P = 0.003) and CC homozygotes of rs2301963 (minor allele A, alternate allele C) at exon 3 (P = 0.0003) were significantly over-represented in the patient group compared to the controls. We also found no differences in the combined frequency of rare missense variants between the two groups. Some of these rare variants were predicted to have an impact on the function of DLGAP2 using informatics analysis, and the family study revealed most of the rare missense mutations in patients were inherited from their unaffected parents.
Conclusions
We detected some common and rare genetic variants of DLGAP2 that might have implication in the pathogenesis of ASD, but they alone may not be sufficient to lead to clinical phenotypes. We suggest that further genetic or environmental factors in affected patients may be present and determine the clinical manifestations. Trial registration ClinicalTrial.gov, NCT00494754En ligne : http://dx.doi.org/10.1186/2040-2392-4-26 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder / Yu-Ju LIN in Journal of Autism and Developmental Disorders, 53-7 (July 2023)
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Titre : Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yu-Ju LIN, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Wen-Che TSAI, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.2555-2569 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study followed up ADHD/autistic symptoms and attentional performance in children/adolescents with ASD and typically developing ones (TD) over 5-7 years. The participants were stratified by age at baseline into child (12 years) and adolescent (12-19 years) groups. ADHD symptoms, especially hyperactivity, and attentional functions significantly improved during follow-up, more in children than in adolescents, in both ASD and TD. Significantly more omission errors and perseverations were noted in ASD than TD through the follow-up. Children with ASD had more improvement in reaction time while adolescents with ASD had less improvement in commission errors and detectability than TD. No correlation of attentional functions and ADHD symptoms in ASD implied different neural mechanisms of ADHD symptoms between ASD and ADHD. En ligne : https://doi.org/10.1007/s10803-022-05445-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507
in Journal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2555-2569[article] Developmental Changes of Autistic Symptoms, ADHD Symptoms, and Attentional Performance in Children and Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yu-Ju LIN, Auteur ; Yen-Nan CHIU, Auteur ; Yu-Yu WU, Auteur ; Wen-Che TSAI, Auteur ; Susan Shur-Fen GAU, Auteur . - p.2555-2569.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-7 (July 2023) . - p.2555-2569
Index. décimale : PER Périodiques Résumé : This study followed up ADHD/autistic symptoms and attentional performance in children/adolescents with ASD and typically developing ones (TD) over 5-7 years. The participants were stratified by age at baseline into child (12 years) and adolescent (12-19 years) groups. ADHD symptoms, especially hyperactivity, and attentional functions significantly improved during follow-up, more in children than in adolescents, in both ASD and TD. Significantly more omission errors and perseverations were noted in ASD than TD through the follow-up. Children with ASD had more improvement in reaction time while adolescents with ASD had less improvement in commission errors and detectability than TD. No correlation of attentional functions and ADHD symptoms in ASD implied different neural mechanisms of ADHD symptoms between ASD and ADHD. En ligne : https://doi.org/10.1007/s10803-022-05445-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 Explaining and Selecting Treatments for Autism: Parental Explanatory Models in Taiwan / Yea-Ing Lotus SHYU in Journal of Autism and Developmental Disorders, 40-11 (November 2010)
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Titre : Explaining and Selecting Treatments for Autism: Parental Explanatory Models in Taiwan Type de document : Texte imprimé et/ou numérique Auteurs : Yea-Ing Lotus SHYU, Auteur ; Jia-Ling TSAI, Auteur ; Wen-Che TSAI, Auteur Année de publication : 2010 Article en page(s) : p.1323-1331 Langues : Anglais (eng) Mots-clés : Taiwan Autism Parental explanatory model Treatment selection Etiology Help seeking Index. décimale : PER Périodiques Résumé : Parental explanatory models about autism influence the type of therapy a child receives, the child’s well-being, and the parents’ own psychological adaptation. This qualitative study explored explanatory models used by parents of children with autism. In-depth interviews were conducted with 13 parents of children with autism from a medical center in Taiwan. Despite high educational background, most of these parents attributed their child’s autism to both biomedical and supernatural etiologies without apparent conflicts. These parents chose a wide variety of treatment strategies, including biomedical and alternative treatments, which often created time/energy pressures and financial burden, and were influenced by parents’ cause attribution. Parents’ illness explanations influence their treatment selections and need to be understood and accepted by health care providers. En ligne : http://dx.doi.org/10.1007/s10803-010-0991-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1323-1331[article] Explaining and Selecting Treatments for Autism: Parental Explanatory Models in Taiwan [Texte imprimé et/ou numérique] / Yea-Ing Lotus SHYU, Auteur ; Jia-Ling TSAI, Auteur ; Wen-Che TSAI, Auteur . - 2010 . - p.1323-1331.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-11 (November 2010) . - p.1323-1331
Mots-clés : Taiwan Autism Parental explanatory model Treatment selection Etiology Help seeking Index. décimale : PER Périodiques Résumé : Parental explanatory models about autism influence the type of therapy a child receives, the child’s well-being, and the parents’ own psychological adaptation. This qualitative study explored explanatory models used by parents of children with autism. In-depth interviews were conducted with 13 parents of children with autism from a medical center in Taiwan. Despite high educational background, most of these parents attributed their child’s autism to both biomedical and supernatural etiologies without apparent conflicts. These parents chose a wide variety of treatment strategies, including biomedical and alternative treatments, which often created time/energy pressures and financial burden, and were influenced by parents’ cause attribution. Parents’ illness explanations influence their treatment selections and need to be understood and accepted by health care providers. En ligne : http://dx.doi.org/10.1007/s10803-010-0991-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=113 Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders / Chia-Hsiang CHEN in Molecular Autism, (June 2014)
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Titre : Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Chia-Hsiang CHEN, Auteur ; Chia-Chun HUANG, Auteur ; Min-Chih CHENG, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Che TSAI, Auteur ; Yu-Yu WU, Auteur ; Shih-Kai LIU, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : GABRB3 is a position candidate gene at chromosome 15q12 that has been implicated in the neurobiology of autism spectrum disorders (ASD). The aim of this study was to examine the genetic association of GABRB3 with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-36 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276
in Molecular Autism > (June 2014) . - p.1-13[article] Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders [Texte imprimé et/ou numérique] / Chia-Hsiang CHEN, Auteur ; Chia-Chun HUANG, Auteur ; Min-Chih CHENG, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Che TSAI, Auteur ; Yu-Yu WU, Auteur ; Shih-Kai LIU, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1-13.
Langues : Anglais (eng)
in Molecular Autism > (June 2014) . - p.1-13
Index. décimale : PER Périodiques Résumé : GABRB3 is a position candidate gene at chromosome 15q12 that has been implicated in the neurobiology of autism spectrum disorders (ASD). The aim of this study was to examine the genetic association of GABRB3 with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-36 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 Impaired sustained attention, focused attention, and vigilance in youths with autistic disorder and Asperger's disorder / Yi-Ling CHIEN in Research in Autism Spectrum Disorders, 8-7 (July 2014)
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PermalinkIncreased gene expression of FOXP1 in patients with autism spectrum disorders / Wei-Hsien CHIEN in Molecular Autism, (July 2013)
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PermalinkInvestigating the impact of probiotic on neurological outcomes in Rett syndrome: A randomized, double-blind, and placebo-controlled pilot study / Chia-Jui HSU ; Yen-Tzu WU ; Hsu-Feng CHU ; Jui-Hsiang LIN ; Hsin-Pei WANG ; Su-Ching HU ; Ying-Chieh TSAI ; Wen-Che TSAI ; Wang-Tso LEE in Autism, 28-9 (September 2024)
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PermalinkA preliminary randomized controlled study of the PEERS® program for Taiwanese autistic adolescents: The effectiveness on reducing school bullying and enhancing social function / Yi-Ling CHIEN ; Yueh-Ming TAI ; Heng-Man CHEN ; Hsien-Hsueh SHIH ; Li-Wei CHEN ; Yu-Ying CHEN ; Wei-Tsuen SOONG ; Yen-Nan CHIU ; Wen-Che TSAI ; Elizabeth LAUGESON ; Mei-Hui TSENG ; Susan Shur-Fen GAU in Autism Research, 17-8 (August 2024)
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PermalinkPsychometric properties of the Chinese version of the Social Responsiveness Scale / Susan Shur-Fen GAU in Research in Autism Spectrum Disorders, 7-2 (February 2013)
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PermalinkThe clinical and sleep manifestations in children with FOXG1 syndrome / Lee-Chin WONG in Autism Research, 16-5 (May 2023)
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PermalinkThe mediators for the link between autism and real-world executive functions in adolescence and young adulthood / Yi-Ling CHIEN in Autism, 28-4 (April 2024)
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PermalinkThe sleep problems in individuals with Rett syndrome and their caregivers / Lee-Chin WONG ; Yen-Ju CHU ; Chia-Jui HSU ; Hsin-Pei WANG ; Wen-Che TSAI ; Wang-Tso LEE in Autism, 28-12 (December 2024)
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PermalinkToddler autism screening questionnaire: Development and potential clinical validity / Wen-Che TSAI in Autism, 16-4 (July 2012)
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