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Détail de l'auteur
Auteur Teresa TAVASSOLI |
Documents disponibles écrits par cet auteur (27)
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Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children / Teresa TAVASSOLI in Molecular Autism, (July 2012)
[article]
Titre : Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children Type de document : Texte imprimé et/ou numérique Auteurs : Teresa TAVASSOLI, Auteur ; Bonnie AUYEUNG, Auteur ; Laura C. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur Année de publication : 2012 Article en page(s) : 12 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background
Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions. In mice, heterozygous Gabrb3 deletion is associated with increased tactile sensitivity. However, no study has examined if tactile sensitivity is associated with GABRB3 genetic variation in humans. To test this, we conducted two pilot genetic association studies in the general population, analysing two phenotypic measures of tactile sensitivity (a parent-report and a behavioural measure) for association with 43 SNPs in GABRB3. Findings Across both tactile sensitivity measures, three SNPs (rs11636966, rs8023959 and rs2162241) were nominally associated with both phenotypes, providing a measure of internal validation. Parent-report scores were nominally associated with six SNPs (P <0.05). Behaviourally measured tactile sensitivity was nominally associated with 10 SNPs (three after Bonferroni correction).
Conclusions
This is the first human study to show an association between GABRB3 variation and tactile sensitivity. This provides support for the evidence from animal models implicating the role of GABRB3 variation in the atypical sensory sensitivity in autism spectrum conditions. Future research is underway to directly test this association in cases of autism spectrum conditions.En ligne : http://dx.doi.org/10.1186/2040-2392-3-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178
in Molecular Autism > (July 2012) . - 12 p.[article] Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children [Texte imprimé et/ou numérique] / Teresa TAVASSOLI, Auteur ; Bonnie AUYEUNG, Auteur ; Laura C. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur . - 2012 . - 12 p.
Langues : Anglais (eng)
in Molecular Autism > (July 2012) . - 12 p.
Index. décimale : PER Périodiques Résumé : Background
Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions. In mice, heterozygous Gabrb3 deletion is associated with increased tactile sensitivity. However, no study has examined if tactile sensitivity is associated with GABRB3 genetic variation in humans. To test this, we conducted two pilot genetic association studies in the general population, analysing two phenotypic measures of tactile sensitivity (a parent-report and a behavioural measure) for association with 43 SNPs in GABRB3. Findings Across both tactile sensitivity measures, three SNPs (rs11636966, rs8023959 and rs2162241) were nominally associated with both phenotypes, providing a measure of internal validation. Parent-report scores were nominally associated with six SNPs (P <0.05). Behaviourally measured tactile sensitivity was nominally associated with 10 SNPs (three after Bonferroni correction).
Conclusions
This is the first human study to show an association between GABRB3 variation and tactile sensitivity. This provides support for the evidence from animal models implicating the role of GABRB3 variation in the atypical sensory sensitivity in autism spectrum conditions. Future research is underway to directly test this association in cases of autism spectrum conditions.En ligne : http://dx.doi.org/10.1186/2040-2392-3-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 A working taxonomy for describing the sensory differences of autism / Zachary J. WILLIAMS ; Ashley HARRIS ; Helen POWELL ; Roseann SCHAAF ; Teresa TAVASSOLI ; Nicolaas A. J. PUTS in Molecular Autism, 14 (2023)
[article]
Titre : A working taxonomy for describing the sensory differences of autism Type de document : Texte imprimé et/ou numérique Auteurs : Zachary J. WILLIAMS, Auteur ; Ashley HARRIS, Auteur ; Helen POWELL, Auteur ; Roseann SCHAAF, Auteur ; Teresa TAVASSOLI, Auteur ; Nicolaas A. J. PUTS, Auteur Article en page(s) : 15 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals on the autism spectrum have been long described to process sensory information differently than neurotypical individuals. While much effort has been leveraged towards characterizing and investigating the neurobiology underlying the sensory differences of autism, there has been a notable lack of consistency in the terms being used to describe the nature of those differences. MAIN BODY: We argue that inconsistent and interchangeable terminology-use when describing the sensory differences of autism has become problematic beyond mere pedantry and inconvenience. We begin by highlighting popular terms that are currently being used to describe the sensory differences of autism (e.g. "sensitivity", "reactivity" and "responsivity") and discuss why poor nomenclature may hamper efforts towards understanding the aetiology of sensory differences in autism. We then provide a solution to poor terminology-use by proposing a hierarchical taxonomy for describing and referring to various sensory features. CONCLUSION: Inconsistent terminology-use when describing the sensory features of autism has stifled discussion and scientific understanding of the sensory differences of autism. The hierarchical taxonomy proposed was developed to help resolve lack of clarity when discussing the sensory differences of autism and to place future research targets at appropriate levels of analysis. En ligne : http://dx.doi.org/10.1186/s13229-022-00534-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 15 p.[article] A working taxonomy for describing the sensory differences of autism [Texte imprimé et/ou numérique] / Zachary J. WILLIAMS, Auteur ; Ashley HARRIS, Auteur ; Helen POWELL, Auteur ; Roseann SCHAAF, Auteur ; Teresa TAVASSOLI, Auteur ; Nicolaas A. J. PUTS, Auteur . - 15 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 15 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals on the autism spectrum have been long described to process sensory information differently than neurotypical individuals. While much effort has been leveraged towards characterizing and investigating the neurobiology underlying the sensory differences of autism, there has been a notable lack of consistency in the terms being used to describe the nature of those differences. MAIN BODY: We argue that inconsistent and interchangeable terminology-use when describing the sensory differences of autism has become problematic beyond mere pedantry and inconvenience. We begin by highlighting popular terms that are currently being used to describe the sensory differences of autism (e.g. "sensitivity", "reactivity" and "responsivity") and discuss why poor nomenclature may hamper efforts towards understanding the aetiology of sensory differences in autism. We then provide a solution to poor terminology-use by proposing a hierarchical taxonomy for describing and referring to various sensory features. CONCLUSION: Inconsistent terminology-use when describing the sensory features of autism has stifled discussion and scientific understanding of the sensory differences of autism. The hierarchical taxonomy proposed was developed to help resolve lack of clarity when discussing the sensory differences of autism and to place future research targets at appropriate levels of analysis. En ligne : http://dx.doi.org/10.1186/s13229-022-00534-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513