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Auteur Zachary J. WILLIAMS |
Documents disponibles écrits par cet auteur (14)
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Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two / Ekomobong E. Eyoh ; Michelle D. FAILLA ; Zachary J. WILLIAMS ; Kyle L. Schwartz ; Laurie E. CUTTING ; Bennett A. LANDMAN ; Carissa J. CASCIO in Journal of Autism and Developmental Disorders, 53-6 (June 2023)
[article]
Titre : Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Zachary J. WILLIAMS, Auteur ; Kyle L. Schwartz, Auteur ; Laurie E. CUTTING, Auteur ; Bennett A. LANDMAN, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.2540-2547 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool, the relative association of each condition in the autistic group was compared to the control group using logistic regressions across medical records. Generalized convulsive epilepsy, nystagmus, lack of normal physiological development, delayed milestones, and strabismus were more likely in those later diagnosed with ASD while perinatal jaundice was less likely to be associated. Lesser-known conditions, such as strabismus and nystagmus, may point to novel predictive co-occurring condition profiles which could improve screening practices for ASD. En ligne : https://doi.org/10.1007/s10803-021-05380-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506
in Journal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2540-2547[article] Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Ekomobong E. Eyoh, Auteur ; Michelle D. FAILLA, Auteur ; Zachary J. WILLIAMS, Auteur ; Kyle L. Schwartz, Auteur ; Laurie E. CUTTING, Auteur ; Bennett A. LANDMAN, Auteur ; Carissa J. CASCIO, Auteur . - p.2540-2547.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-6 (June 2023) . - p.2540-2547
Index. décimale : PER Périodiques Résumé : In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool, the relative association of each condition in the autistic group was compared to the control group using logistic regressions across medical records. Generalized convulsive epilepsy, nystagmus, lack of normal physiological development, delayed milestones, and strabismus were more likely in those later diagnosed with ASD while perinatal jaundice was less likely to be associated. Lesser-known conditions, such as strabismus and nystagmus, may point to novel predictive co-occurring condition profiles which could improve screening practices for ASD. En ligne : https://doi.org/10.1007/s10803-021-05380-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=506 Characterizing Interoceptive Differences in Autism: A Systematic Review and Meta-analysis of Case-control Studies / Zachary J. WILLIAMS in Journal of Autism and Developmental Disorders, 53-3 (March 2023)
[article]
Titre : Characterizing Interoceptive Differences in Autism: A Systematic Review and Meta-analysis of Case-control Studies Type de document : Texte imprimé et/ou numérique Auteurs : Zachary J. WILLIAMS, Auteur ; Evan SUZMAN, Auteur ; Samantha L. BORDMAN, Auteur ; Jennifer E. MARKFELD, Auteur ; Sophia M. KAISER, Auteur ; Kacie A. DUNHAM, Auteur ; Alisa R. ZOLTOWSKI, Auteur ; Michelle D. FAILLA, Auteur ; Carissa J. CASCIO, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : p.947-962 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Interoception, the body?s perception of its own internal states, is thought to be altered in autism, though results of empirical studies have been inconsistent. The current study systematically reviewed and meta-analyzed the extant literature comparing interoceptive outcomes between autistic (AUT) and neurotypical (NT) individuals, determining which domains of interoception demonstrate robust between-group differences. A three-level Bayesian meta-analysis compared heartbeat counting performance, heartbeat discrimination performance, heartbeat counting confidence ratings, and self-reported interoceptive attention between AUT and NT groups (15 studies; nAUT=467, nNT=478). Autistic participants showed significantly reduced heartbeat counting performance [g=? 0.333, CrI95% (? 0.535, ? 0.138)] and higher confidence in their heartbeat counting abilities [g=0.430, CrI95% (0.123, 0.750)], but groups were equivalent on other meta-analyzed outcomes. Implications for future interoception research in autism are discussed. En ligne : https://doi.org/10.1007/s10803-022-05656-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500
in Journal of Autism and Developmental Disorders > 53-3 (March 2023) . - p.947-962[article] Characterizing Interoceptive Differences in Autism: A Systematic Review and Meta-analysis of Case-control Studies [Texte imprimé et/ou numérique] / Zachary J. WILLIAMS, Auteur ; Evan SUZMAN, Auteur ; Samantha L. BORDMAN, Auteur ; Jennifer E. MARKFELD, Auteur ; Sophia M. KAISER, Auteur ; Kacie A. DUNHAM, Auteur ; Alisa R. ZOLTOWSKI, Auteur ; Michelle D. FAILLA, Auteur ; Carissa J. CASCIO, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - p.947-962.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-3 (March 2023) . - p.947-962
Index. décimale : PER Périodiques Résumé : Interoception, the body?s perception of its own internal states, is thought to be altered in autism, though results of empirical studies have been inconsistent. The current study systematically reviewed and meta-analyzed the extant literature comparing interoceptive outcomes between autistic (AUT) and neurotypical (NT) individuals, determining which domains of interoception demonstrate robust between-group differences. A three-level Bayesian meta-analysis compared heartbeat counting performance, heartbeat discrimination performance, heartbeat counting confidence ratings, and self-reported interoceptive attention between AUT and NT groups (15 studies; nAUT=467, nNT=478). Autistic participants showed significantly reduced heartbeat counting performance [g=? 0.333, CrI95% (? 0.535, ? 0.138)] and higher confidence in their heartbeat counting abilities [g=0.430, CrI95% (0.123, 0.750)], but groups were equivalent on other meta-analyzed outcomes. Implications for future interoception research in autism are discussed. En ligne : https://doi.org/10.1007/s10803-022-05656-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 Current and lifetime somatic symptom burden among transition-aged autistic young adults / Zachary J. WILLIAMS in Autism Research, 15-4 (April 2022)
[article]
Titre : Current and lifetime somatic symptom burden among transition-aged autistic young adults Type de document : Texte imprimé et/ou numérique Auteurs : Zachary J. WILLIAMS, Auteur ; Katherine O. GOTHAM, Auteur Article en page(s) : p.761-770 Langues : Anglais (eng) Mots-clés : Adolescent Adult Aged Anxiety/epidemiology Autism Spectrum Disorder/psychology Autistic Disorder/complications/epidemiology/psychology Female Humans Male Medically Unexplained Symptoms Quality of Life Young Adult autism bodily distress syndrome physical symptoms prevalence sex differences somatic symptoms somatization Index. décimale : PER Périodiques Résumé : Somatic symptoms are the most common cause of outpatient medical visits in the general population, yet their presence and severity in individuals on the autism spectrum has rarely been studied. We sought to assess the prevalence, impact, and clinical correlates of 14 commonly reported somatic symptoms in a sample of 290 transition-aged autistic young adults (mean [SD] age: 23.10 [2.38] years, range 18-26; 76.7% diagnosed with autism before age 18) recruited from the Simons Foundation SPARK participant pool. A modified version of the Patient Health Questionnaire-15 was used to assess somatic symptom prevalence/impact, along with measures of depression, anxiety, autistic traits, and quality of life. Somatic symptom burden was much higher in autistic young adults than previously reported in the general population. The most commonly reported current symptoms were fatigue (72.8%), sleep problems (69.0%), and menstrual problems (61.4% of females). Moderate or severe symptom levels were reported by 53.9% of females and 18.75% of males in our cohort, with the odds of females endorsing any given symptom being 2-4 times greater than males. Both individual symptoms and total symptom burden were related to higher levels of depression, anxiety, and autistic traits, along with lower quality of life. Despite little research on this topic previously, somatic symptoms are highly prevalent in autistic young adults, particularly women. Future research is needed to investigate links between somatic symptoms, medical and psychiatric morbidity, and health care utilization in the autistic population. LAY SUMMARY: Somatic symptoms (i.e., physical symptoms such as such as pain, weakness, stomachache, or shortness of breath) are highly prevalent in the general population and account for a large proportion of health care costs. However, few studies have investigated how often these symptoms are reported by autistic adults or their associations with other clinical and demographic variables. Based on self-report data from 290 young autistic adults, we found very high rates of bothersome somatic symptoms in this population, with females endorsing all symptoms at substantially higher rates than males. Somatic symptoms were also associated with worse mental health and quality of life, suggesting that they represent an overlooked contributor to poor health outcomes in the autistic adult population. En ligne : https://dx.doi.org/10.1002/aur.2671 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473
in Autism Research > 15-4 (April 2022) . - p.761-770[article] Current and lifetime somatic symptom burden among transition-aged autistic young adults [Texte imprimé et/ou numérique] / Zachary J. WILLIAMS, Auteur ; Katherine O. GOTHAM, Auteur . - p.761-770.
Langues : Anglais (eng)
in Autism Research > 15-4 (April 2022) . - p.761-770
Mots-clés : Adolescent Adult Aged Anxiety/epidemiology Autism Spectrum Disorder/psychology Autistic Disorder/complications/epidemiology/psychology Female Humans Male Medically Unexplained Symptoms Quality of Life Young Adult autism bodily distress syndrome physical symptoms prevalence sex differences somatic symptoms somatization Index. décimale : PER Périodiques Résumé : Somatic symptoms are the most common cause of outpatient medical visits in the general population, yet their presence and severity in individuals on the autism spectrum has rarely been studied. We sought to assess the prevalence, impact, and clinical correlates of 14 commonly reported somatic symptoms in a sample of 290 transition-aged autistic young adults (mean [SD] age: 23.10 [2.38] years, range 18-26; 76.7% diagnosed with autism before age 18) recruited from the Simons Foundation SPARK participant pool. A modified version of the Patient Health Questionnaire-15 was used to assess somatic symptom prevalence/impact, along with measures of depression, anxiety, autistic traits, and quality of life. Somatic symptom burden was much higher in autistic young adults than previously reported in the general population. The most commonly reported current symptoms were fatigue (72.8%), sleep problems (69.0%), and menstrual problems (61.4% of females). Moderate or severe symptom levels were reported by 53.9% of females and 18.75% of males in our cohort, with the odds of females endorsing any given symptom being 2-4 times greater than males. Both individual symptoms and total symptom burden were related to higher levels of depression, anxiety, and autistic traits, along with lower quality of life. Despite little research on this topic previously, somatic symptoms are highly prevalent in autistic young adults, particularly women. Future research is needed to investigate links between somatic symptoms, medical and psychiatric morbidity, and health care utilization in the autistic population. LAY SUMMARY: Somatic symptoms (i.e., physical symptoms such as such as pain, weakness, stomachache, or shortness of breath) are highly prevalent in the general population and account for a large proportion of health care costs. However, few studies have investigated how often these symptoms are reported by autistic adults or their associations with other clinical and demographic variables. Based on self-report data from 290 young autistic adults, we found very high rates of bothersome somatic symptoms in this population, with females endorsing all symptoms at substantially higher rates than males. Somatic symptoms were also associated with worse mental health and quality of life, suggesting that they represent an overlooked contributor to poor health outcomes in the autistic adult population. En ligne : https://dx.doi.org/10.1002/aur.2671 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 Habituation of auditory responses in young autistic and neurotypical children / Patrick DWYER in Autism Research, 16-10 (October 2023)
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Titre : Habituation of auditory responses in young autistic and neurotypical children Type de document : Texte imprimé et/ou numérique Auteurs : Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.1903-1923 Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80?dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ?=?65.41, SD?=?20.54) and 79 typically developing (MDQ?=?106.02, SD?=?11.50) children between 2 and 5?years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80?dB sounds than softer sounds, whereas the N2 habituated less to soft 50?dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Autism Research > 16-10 (October 2023) . - p.1903-1923[article] Habituation of auditory responses in young autistic and neurotypical children [Texte imprimé et/ou numérique] / Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.1903-1923.
in Autism Research > 16-10 (October 2023) . - p.1903-1923
Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80?dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ?=?65.41, SD?=?20.54) and 79 typically developing (MDQ?=?106.02, SD?=?11.50) children between 2 and 5?years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80?dB sounds than softer sounds, whereas the N2 habituated less to soft 50?dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 Investigating the structure of trait rumination in autistic adults: A network analysis / Zachary J. WILLIAMS in Autism, 26-7 (October 2022)
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Titre : Investigating the structure of trait rumination in autistic adults: A network analysis Type de document : Texte imprimé et/ou numérique Auteurs : Zachary J. WILLIAMS, Auteur ; Erin E. MCKENNEY, Auteur ; Katherine O. GOTHAM, Auteur Article en page(s) : p.2048-2063 Langues : Anglais (eng) Mots-clés : Adult Anxiety Disorders Autism Spectrum Disorder Autistic Disorder Depression Humans Surveys and Questionnaires adults autism spectrum disorders brooding centrality network analysis psychiatric comorbidity reflection rumination stock/stock options in Axsome Therapeutics, Editas Medicine, CRISPR Therapeutics, and Fulgent Genetics. ZJW also serves on the family advisory committee of the Autism Speaks Autism Learning Health Network Vanderbilt site and the autistic researcher review board of the Autism Intervention Network for Physical Health (AIR-P). The other authors declare no competing interests. Index. décimale : PER Périodiques Résumé : Autistic adults are substantially more likely to develop depression than individuals in the general population, and recent research has indicated that certain differences in thinking styles associated with autism may play a role in this association. Rumination, the act of thinking about the same thing over and over without a functional outcome, is a significant risk factor for depression in both autistic and non-autistic adults. However, little is known about how different kinds of rumination relate to each other and to depressive symptoms in the autistic population specifically. To fill this gap in knowledge, we recruited a large online sample of autistic adults, who completed questionnaire measures of both the tendency to ruminate and symptoms of depression. By examining the interacting network of rumination and depression symptoms, this study was able to identify particular aspects of rumination-such as thinking repetitively about one's guilty feelings or criticizing oneself-that may be particularly important in maintaining these harmful thought patterns in autistic adults. Although further study is needed, it is possible that the symptoms identified as most "influential" in the network may be particularly good targets for future interventions for mood and anxiety disorders in the autistic population. En ligne : http://dx.doi.org/10.1177/13623613211012855 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Autism > 26-7 (October 2022) . - p.2048-2063[article] Investigating the structure of trait rumination in autistic adults: A network analysis [Texte imprimé et/ou numérique] / Zachary J. WILLIAMS, Auteur ; Erin E. MCKENNEY, Auteur ; Katherine O. GOTHAM, Auteur . - p.2048-2063.
Langues : Anglais (eng)
in Autism > 26-7 (October 2022) . - p.2048-2063
Mots-clés : Adult Anxiety Disorders Autism Spectrum Disorder Autistic Disorder Depression Humans Surveys and Questionnaires adults autism spectrum disorders brooding centrality network analysis psychiatric comorbidity reflection rumination stock/stock options in Axsome Therapeutics, Editas Medicine, CRISPR Therapeutics, and Fulgent Genetics. ZJW also serves on the family advisory committee of the Autism Speaks Autism Learning Health Network Vanderbilt site and the autistic researcher review board of the Autism Intervention Network for Physical Health (AIR-P). The other authors declare no competing interests. Index. décimale : PER Périodiques Résumé : Autistic adults are substantially more likely to develop depression than individuals in the general population, and recent research has indicated that certain differences in thinking styles associated with autism may play a role in this association. Rumination, the act of thinking about the same thing over and over without a functional outcome, is a significant risk factor for depression in both autistic and non-autistic adults. However, little is known about how different kinds of rumination relate to each other and to depressive symptoms in the autistic population specifically. To fill this gap in knowledge, we recruited a large online sample of autistic adults, who completed questionnaire measures of both the tendency to ruminate and symptoms of depression. By examining the interacting network of rumination and depression symptoms, this study was able to identify particular aspects of rumination-such as thinking repetitively about one's guilty feelings or criticizing oneself-that may be particularly important in maintaining these harmful thought patterns in autistic adults. Although further study is needed, it is possible that the symptoms identified as most "influential" in the network may be particularly good targets for future interventions for mood and anxiety disorders in the autistic population. En ligne : http://dx.doi.org/10.1177/13623613211012855 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 Learning from the experts: Evaluating a participatory autism and universal design training for university educators / TC WAISMAN in Autism, 27-2 (February 2023)
PermalinkMeasurement matters: A commentary on the state of the science on patient reported outcome measures (PROMs) in autism research / Hillary K. SCHILTZ in Autism Research, 17-4 (April 2024)
PermalinkMeasuring subjective quality of life in autistic adults with the PROMIS global-10: Psychometric study and development of an autism-specific scoring method / Zachary J. WILLIAMS in Autism, 27-1 (January 2023)
Permalink?Neural Noise? in Auditory Responses in Young Autistic and Neurotypical Children / Svjetlana VUKUSIC ; Zachary J. WILLIAMS ; Clifford D. SARON ; Susan M. RIVERA in Journal of Autism and Developmental Disorders, 54-2 (February 2024)
PermalinkNeurodiversity and Autism Intervention: Reconciling Perspectives Through a Naturalistic Developmental Behavioral Intervention Framework / Rachel K. SCHUCK in Journal of Autism and Developmental Disorders, 52-10 (October 2022)
PermalinkA Randomized Controlled Trial for Audiovisual Multisensory Perception in Autistic Youth / Jacob I. FELDMAN in Journal of Autism and Developmental Disorders, 53-11 (November 2023)
PermalinkSocial Validity of Pivotal Response Treatment for Young Autistic Children: Perspectives of Autistic Adults / Patrick DWYER ; Kaitlynn M. P. BAIDEN ; Zachary J. WILLIAMS ; Mian WANG in Journal of Autism and Developmental Disorders, 54-2 (February 2024)
PermalinkThe INSAR Community Collaborator Request: Using community-academic partnerships to enhance outcomes of participatory autism research / Patrick DWYER ; Dena GASSNER ; Melanie HEYWORTH ; Zachary J. WILLIAMS in Autism Research, 16-11 (November 2023)
PermalinkA working taxonomy for describing the sensory differences of autism / Zachary J. WILLIAMS ; Ashley HARRIS ; Helen POWELL ; Roseann SCHAAF ; Teresa TAVASSOLI ; Nicolaas A. J. PUTS in Molecular Autism, 14 (2023)
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