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Détail de l'auteur
Auteur James W. HOWELL |
Documents disponibles écrits par cet auteur (1)
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Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders / Detlef H. HECK in Autism - Open Access, 3-1 (March 2013)
[article]
Titre : Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Detlef H. HECK, Auteur ; James W. HOWELL, Auteur Année de publication : 2013 Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Schizophrenia Dopamine Index. décimale : PER Périodiques Résumé : This review reveals possible explanations for the link between cerebellar neuropathology and cognitive disorders,
with an emphasis on autism and schizophrenia. There is a growing body of evidence showing these two conditions
to be related. The loss of Purkinje cells, the principal neurons of the cerebellar cortex, is one of the most consistent
neuropathologies found in autistic brains. Cerebellar neurophathologies are a common finding in schizophrenia, as
well. The cerebellum has long been considered a pure motor structure, and it’s involvement in cognitive disorders
remained obscure. The cognitive deficits typically associated with autism and schizophrenia strongly implicate
prefrontal cerebral cortical pathology. We review recent findings, which provide new insights into suggest possible
neuronal mechanisms through which the cerebellum might interact with the prefrontal cortex during cognitive tasks.
In addition to exploring the link between autism and schizophrenia, we point out several opportunities for further
study, including the selective pruning of nerve cells and collaterals during development, communication systems
between the prefrontal cortex and the cerebellum, exploration of the genome, effects of autism and schizophrenia on
intelligence, and a focus on the epidemiology of autism.En ligne : http://dx.doi.org/10.4172/2165-7890.S4-001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Autism - Open Access > 3-1 (March 2013) . - 4 p.[article] Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Detlef H. HECK, Auteur ; James W. HOWELL, Auteur . - 2013 . - 4 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 4 p.
Mots-clés : Autism spectrum disorders Schizophrenia Dopamine Index. décimale : PER Périodiques Résumé : This review reveals possible explanations for the link between cerebellar neuropathology and cognitive disorders,
with an emphasis on autism and schizophrenia. There is a growing body of evidence showing these two conditions
to be related. The loss of Purkinje cells, the principal neurons of the cerebellar cortex, is one of the most consistent
neuropathologies found in autistic brains. Cerebellar neurophathologies are a common finding in schizophrenia, as
well. The cerebellum has long been considered a pure motor structure, and it’s involvement in cognitive disorders
remained obscure. The cognitive deficits typically associated with autism and schizophrenia strongly implicate
prefrontal cerebral cortical pathology. We review recent findings, which provide new insights into suggest possible
neuronal mechanisms through which the cerebellum might interact with the prefrontal cortex during cognitive tasks.
In addition to exploring the link between autism and schizophrenia, we point out several opportunities for further
study, including the selective pruning of nerve cells and collaterals during development, communication systems
between the prefrontal cortex and the cerebellum, exploration of the genome, effects of autism and schizophrenia on
intelligence, and a focus on the epidemiology of autism.En ligne : http://dx.doi.org/10.4172/2165-7890.S4-001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228