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3-1 - March 2013 [Texte imprimé et/ou numérique] . - 2013. Langues : Anglais (eng)
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Dépouillements


Self-Determination Instructional Delivery, Value and Knowledge of General and Special Education Teachers and Across Grade Levels / Francine BAFFA in Autism - Open Access, 3-1 (March 2013)
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Titre : Self-Determination Instructional Delivery, Value and Knowledge of General and Special Education Teachers and Across Grade Levels Type de document : Texte imprimé et/ou numérique Auteurs : Francine BAFFA, Auteur Année de publication : 2013 Article en page(s) : 1 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Autism - Open Access > 3-1 (March 2013) . - 1 p.[article] Self-Determination Instructional Delivery, Value and Knowledge of General and Special Education Teachers and Across Grade Levels [Texte imprimé et/ou numérique] / Francine BAFFA, Auteur . - 2013 . - 1 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 1 p.
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised / Ulrika ROINE in Autism - Open Access, 3-1 (March 2013)
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Titre : Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis.
Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study.
Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too.
Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders.En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Autism - Open Access > 3-1 (March 2013) . - 9 p.[article] Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur . - 2013 . - 9 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 9 p.
Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis.
Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study.
Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too.
Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders.En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Teacher Implementation of Joint Attention Intervention in Preschool Classrooms: Fidelity and Context / Kathy LAWTON in Autism - Open Access, 3-1 (March 2013)
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Titre : Teacher Implementation of Joint Attention Intervention in Preschool Classrooms: Fidelity and Context Type de document : Texte imprimé et/ou numérique Auteurs : Kathy LAWTON, Auteur ; Connie KASARI, Auteur Année de publication : 2013 Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent studies suggest that preschool teachers can improve core autism deficits. Implementation fidelity,
however, has not been a focus. This study examined the ability of sixteen preschool teachers to implement strategies of a manualized communication intervention targeting the core deficit of joint attention. Before treatment, teachers in both groups used few strategies, but they demonstrated more intervention strategies during individual child and teacher play interactions than in their classrooms. After treatment, teachers in the immediate treatment group used significantly more strategies than the control group with notable differences in their use of strategies in their classrooms. Results also suggest that some strategies may be easier than others for teachers to adopt.En ligne : http://dx.doi.org/10.4172/2165-7890.1000108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Autism - Open Access > 3-1 (March 2013) . - 6 p.[article] Teacher Implementation of Joint Attention Intervention in Preschool Classrooms: Fidelity and Context [Texte imprimé et/ou numérique] / Kathy LAWTON, Auteur ; Connie KASARI, Auteur . - 2013 . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 6 p.
Index. décimale : PER Périodiques Résumé : Recent studies suggest that preschool teachers can improve core autism deficits. Implementation fidelity,
however, has not been a focus. This study examined the ability of sixteen preschool teachers to implement strategies of a manualized communication intervention targeting the core deficit of joint attention. Before treatment, teachers in both groups used few strategies, but they demonstrated more intervention strategies during individual child and teacher play interactions than in their classrooms. After treatment, teachers in the immediate treatment group used significantly more strategies than the control group with notable differences in their use of strategies in their classrooms. Results also suggest that some strategies may be easier than others for teachers to adopt.En ligne : http://dx.doi.org/10.4172/2165-7890.1000108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Early Intervention Issues in Autism Spectrum Disorders / Linda COPELAND in Autism - Open Access, 3-1 (March 2013)
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Titre : Early Intervention Issues in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Linda COPELAND, Auteur ; Greg BUCH, Auteur Année de publication : 2013 Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Autism - Open Access > 3-1 (March 2013) . - 7 p.[article] Early Intervention Issues in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Linda COPELAND, Auteur ; Greg BUCH, Auteur . - 2013 . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 7 p.
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Treatment of the Child with Autism-Newest Medical Trends / Dario SINISCALCO in Autism - Open Access, 3-1 (March 2013)
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[article]
Titre : Treatment of the Child with Autism-Newest Medical Trends Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Magdalena CUBALA-KUCHARSKA, Auteur Année de publication : 2013 Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Autism - Open Access > 3-1 (March 2013) . - 2 p.[article] Treatment of the Child with Autism-Newest Medical Trends [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Magdalena CUBALA-KUCHARSKA, Auteur . - 2013 . - 2 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 2 p.
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders / Detlef H. HECK in Autism - Open Access, 3-1 (March 2013)
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Titre : Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Detlef H. HECK, Auteur ; James W. HOWELL, Auteur Année de publication : 2013 Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Schizophrenia Dopamine Index. décimale : PER Périodiques Résumé : This review reveals possible explanations for the link between cerebellar neuropathology and cognitive disorders,
with an emphasis on autism and schizophrenia. There is a growing body of evidence showing these two conditions
to be related. The loss of Purkinje cells, the principal neurons of the cerebellar cortex, is one of the most consistent
neuropathologies found in autistic brains. Cerebellar neurophathologies are a common finding in schizophrenia, as
well. The cerebellum has long been considered a pure motor structure, and it’s involvement in cognitive disorders
remained obscure. The cognitive deficits typically associated with autism and schizophrenia strongly implicate
prefrontal cerebral cortical pathology. We review recent findings, which provide new insights into suggest possible
neuronal mechanisms through which the cerebellum might interact with the prefrontal cortex during cognitive tasks.
In addition to exploring the link between autism and schizophrenia, we point out several opportunities for further
study, including the selective pruning of nerve cells and collaterals during development, communication systems
between the prefrontal cortex and the cerebellum, exploration of the genome, effects of autism and schizophrenia on
intelligence, and a focus on the epidemiology of autism.En ligne : http://dx.doi.org/10.4172/2165-7890.S4-001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Autism - Open Access > 3-1 (March 2013) . - 4 p.[article] Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Detlef H. HECK, Auteur ; James W. HOWELL, Auteur . - 2013 . - 4 p.
Langues : Anglais (eng)
in Autism - Open Access > 3-1 (March 2013) . - 4 p.
Mots-clés : Autism spectrum disorders Schizophrenia Dopamine Index. décimale : PER Périodiques Résumé : This review reveals possible explanations for the link between cerebellar neuropathology and cognitive disorders,
with an emphasis on autism and schizophrenia. There is a growing body of evidence showing these two conditions
to be related. The loss of Purkinje cells, the principal neurons of the cerebellar cortex, is one of the most consistent
neuropathologies found in autistic brains. Cerebellar neurophathologies are a common finding in schizophrenia, as
well. The cerebellum has long been considered a pure motor structure, and it’s involvement in cognitive disorders
remained obscure. The cognitive deficits typically associated with autism and schizophrenia strongly implicate
prefrontal cerebral cortical pathology. We review recent findings, which provide new insights into suggest possible
neuronal mechanisms through which the cerebellum might interact with the prefrontal cortex during cognitive tasks.
In addition to exploring the link between autism and schizophrenia, we point out several opportunities for further
study, including the selective pruning of nerve cells and collaterals during development, communication systems
between the prefrontal cortex and the cerebellum, exploration of the genome, effects of autism and schizophrenia on
intelligence, and a focus on the epidemiology of autism.En ligne : http://dx.doi.org/10.4172/2165-7890.S4-001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228