Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder / Gail A. ALVARES in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.25-41 Titre : Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gail A. ALVARES, Auteur ; Daniel S. QUINTANA, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.25-41 Langues : Anglais (eng) Mots-clés : oxytocin  neuropeptide  hormones  nasal spray Index. décimale : PER Périodiques Résumé : Extensive research efforts in the last decade have been expended into understanding whether intranasal oxytocin may be an effective therapeutic in treating social communication impairments in individuals with autism spectrum disorder (ASD). After much hyped early findings, subsequent clinical trials of longer-term administration have yielded more conservative and mixed evidence. However, it is still unclear at this stage whether these more disappointing findings reflect a true null effect or are mitigated by methodological differences masking true effects. In this review, we comprehensively evaluate the rationale for oxytocin as a therapeutic, evaluating evidence from randomized controlled trials, case reports, and open-label studies of oxytocin administration in individuals with ASD. The evidence to date, including reviews of preregistered trials, suggests a number of critical considerations for the design and interpretation of research in this area. These include considering the choice of ASD outcome measures, dosing and nasal spray device issues, and participant selection. Despite these limitations in the field to date, there remains significant potential for oxytocin to ameliorate aspects of the persistent and debilitating social impairments in individuals with ASD. Given the considerable media hype around new treatments for ASD, as well as the needs of eager families, there is an urgent need for researchers to prioritise considering such factors when conducting well-designed and controlled studies to further advance this field. En ligne : http://dx.doi.org/10.1002/aur.1692 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=302 [article] Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; Daniel S. QUINTANA, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.25-41. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.25-41 Mots-clés : oxytocin  neuropeptide  hormones  nasal spray Index. décimale : PER Périodiques Résumé : Extensive research efforts in the last decade have been expended into understanding whether intranasal oxytocin may be an effective therapeutic in treating social communication impairments in individuals with autism spectrum disorder (ASD). After much hyped early findings, subsequent clinical trials of longer-term administration have yielded more conservative and mixed evidence. However, it is still unclear at this stage whether these more disappointing findings reflect a true null effect or are mitigated by methodological differences masking true effects. In this review, we comprehensively evaluate the rationale for oxytocin as a therapeutic, evaluating evidence from randomized controlled trials, case reports, and open-label studies of oxytocin administration in individuals with ASD. The evidence to date, including reviews of preregistered trials, suggests a number of critical considerations for the design and interpretation of research in this area. These include considering the choice of ASD outcome measures, dosing and nasal spray device issues, and participant selection. Despite these limitations in the field to date, there remains significant potential for oxytocin to ameliorate aspects of the persistent and debilitating social impairments in individuals with ASD. Given the considerable media hype around new treatments for ASD, as well as the needs of eager families, there is an urgent need for researchers to prioritise considering such factors when conducting well-designed and controlled studies to further advance this field. En ligne : http://dx.doi.org/10.1002/aur.1692 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=302

Heart rate variability during social interactions in children with and without psychopathology: a meta-analysis / Sara SHAHRESTANI in Journal of Child Psychology and Psychiatry, 55-9 (September 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.981-989 Titre : Heart rate variability during social interactions in children with and without psychopathology: a meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Sara SHAHRESTANI, Auteur ; Elizabeth M. STEWART, Auteur ; Daniel S. QUINTANA, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.981-989 Langues : Anglais (eng) Mots-clés : Social behaviour  psychopathology  psychophysiology  Meta-analysis Index. décimale : PER Périodiques Résumé : Background The inability to regulate autonomic activity during social interactions is believed to contribute to social and emotional dysregulation in children. Research has employed heart rate variability (HRV) during both socially engaging and socially disengaging dyadic tasks between children and adults to assess this. Methods We conducted a meta-analysis including evidence from 18 studies comprising 1,544 children who were categorized as either healthy or at risk/diagnosed with psychopathology. Within these groups, we assessed the impact of social engagement and disengagement tasks on HRV. Results Results showed that social engagement tasks left HRV unaltered to a baseline. Social disengagement, however, was associated with decreases in HRV. In a task that included disengagement and then engagement, HRV was reduced during disengagement but was then restored during the reunion phase (engagement). Children at risk or with a diagnosis for psychopathology, however, failed to show any change in HRV during dyadic social interaction tasks. This was despite a social stressor, the Trier Social Stress Test, causing significantly reduced HRV in both groups. Conclusions This meta-analysis provides support to suggest HRV may provide a worthwhile context specific marker for the effective regulation of dyadic social interactions in children. En ligne : http://dx.doi.org/10.1111/jcpp.12226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Heart rate variability during social interactions in children with and without psychopathology: a meta-analysis [Texte imprimé et/ou numérique] / Sara SHAHRESTANI, Auteur ; Elizabeth M. STEWART, Auteur ; Daniel S. QUINTANA, Auteur ; Ian B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur . - p.981-989. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.981-989 Mots-clés : Social behaviour  psychopathology  psychophysiology  Meta-analysis Index. décimale : PER Périodiques Résumé : Background The inability to regulate autonomic activity during social interactions is believed to contribute to social and emotional dysregulation in children. Research has employed heart rate variability (HRV) during both socially engaging and socially disengaging dyadic tasks between children and adults to assess this. Methods We conducted a meta-analysis including evidence from 18 studies comprising 1,544 children who were categorized as either healthy or at risk/diagnosed with psychopathology. Within these groups, we assessed the impact of social engagement and disengagement tasks on HRV. Results Results showed that social engagement tasks left HRV unaltered to a baseline. Social disengagement, however, was associated with decreases in HRV. In a task that included disengagement and then engagement, HRV was reduced during disengagement but was then restored during the reunion phase (engagement). Children at risk or with a diagnosis for psychopathology, however, failed to show any change in HRV during dyadic social interaction tasks. This was despite a social stressor, the Trier Social Stress Test, causing significantly reduced HRV in both groups. Conclusions This meta-analysis provides support to suggest HRV may provide a worthwhile context specific marker for the effective regulation of dyadic social interactions in children. En ligne : http://dx.doi.org/10.1111/jcpp.12226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder / Tonje TORSKE in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Titre : Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete G. ØIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.3847-3859 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tonje TORSKE, Auteur ; Terje NÆRLAND, Auteur ; Daniel S. QUINTANA, Auteur ; Ruth Elizabeth HYPHER, Auteur ; Anett KAALE, Auteur ; Anne Lise HØYLAND, Auteur ; Sigrun HOPE, Auteur ; Jarle JOHANNESSEN, Auteur ; Merete G. ØIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.3847-3859. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3847-3859 Index. décimale : PER Périodiques Résumé : Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p<0.001) and communication (p=0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. En ligne : https://doi.org/10.1007/s10803-022-05629-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

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