ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD / Jeffery N. EPSTEIN in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.899–913 Titre : ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Jeffery N. EPSTEIN, Auteur ; Lisa A. KOTLER, Auteur ; Alan VITOLO, Auteur ; Keith M. SHAFRITZ, Auteur ; Gary GLOVER, Auteur ; Amy GARRETT, Auteur ; Julie A. SPICER, Auteur ; Matthew C. DAVIDSON, Auteur ; B.J. CASEY, Auteur ; Allan L. REISS, Auteur ; Stephen P. HINSHAW, Auteur ; Laurence L. GREENHILL, Auteur ; Simon T. TONEV, Auteur ; Matthew A. JARRETT, Auteur Année de publication : 2007 Article en page(s) : p.899–913 Langues : Anglais (eng) Mots-clés : ADHD adolescence adulthood brain-imaging development fMRI methylphenidate neuropsychology children parents Index. décimale : PER Périodiques Résumé : Background: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. Method: A group of concordantly diagnosed ADHD parent–child dyads was compared to a matched sample of normal parent–child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. Results: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. Conclusions: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01761.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=163 [article] ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD [Texte imprimé et/ou numérique] / Jeffery N. EPSTEIN, Auteur ; Lisa A. KOTLER, Auteur ; Alan VITOLO, Auteur ; Keith M. SHAFRITZ, Auteur ; Gary GLOVER, Auteur ; Amy GARRETT, Auteur ; Julie A. SPICER, Auteur ; Matthew C. DAVIDSON, Auteur ; B.J. CASEY, Auteur ; Allan L. REISS, Auteur ; Stephen P. HINSHAW, Auteur ; Laurence L. GREENHILL, Auteur ; Simon T. TONEV, Auteur ; Matthew A. JARRETT, Auteur . - 2007 . - p.899–913. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.899–913 Mots-clés : ADHD adolescence adulthood brain-imaging development fMRI methylphenidate neuropsychology children parents Index. décimale : PER Périodiques Résumé : Background: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. Method: A group of concordantly diagnosed ADHD parent–child dyads was compared to a matched sample of normal parent–child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. Results: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. Conclusions: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01761.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=163

The role of the amygdala in bipolar disorder development / Amy GARRETT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1285-1296 Titre : The role of the amygdala in bipolar disorder development Type de document : Texte imprimé et/ou numérique Auteurs : Amy GARRETT, Auteur ; Kiki D. CHANG, Auteur Année de publication : 2008 Article en page(s) : p.1285-1296 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development. En ligne : http://dx.doi.org/10.1017/s0954579408000618 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603 [article] The role of the amygdala in bipolar disorder development [Texte imprimé et/ou numérique] / Amy GARRETT, Auteur ; Kiki D. CHANG, Auteur . - 2008 . - p.1285-1296. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1285-1296 Index. décimale : PER Périodiques Résumé : The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development. En ligne : http://dx.doi.org/10.1017/s0954579408000618 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603

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