Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention / H. Harrington CLEVELAND in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.297-313 Titre : Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention Type de document : Texte imprimé et/ou numérique Auteurs : H. Harrington CLEVELAND, Auteur ; Gabriel L. SCHLOMER, Auteur ; David J. VANDENBERGH, Auteur ; Pedro S. A. WOLF, Auteur ; Mark E. FEINBERG, Auteur ; Mark T. GREENBERG, Auteur ; Richard L. SPOTH, Auteur ; Cleve REDMOND, Auteur Article en page(s) : p.297-313 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions. En ligne : https://doi.org/10.1017/S0954579417000633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention [Texte imprimé et/ou numérique] / H. Harrington CLEVELAND, Auteur ; Gabriel L. SCHLOMER, Auteur ; David J. VANDENBERGH, Auteur ; Pedro S. A. WOLF, Auteur ; Mark E. FEINBERG, Auteur ; Mark T. GREENBERG, Auteur ; Richard L. SPOTH, Auteur ; Cleve REDMOND, Auteur . - p.297-313. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.297-313 Index. décimale : PER Périodiques Résumé : Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions. En ligne : https://doi.org/10.1017/S0954579417000633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants / H. Harrington CLEVELAND in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.51-67 Titre : The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants Type de document : Texte imprimé et/ou numérique Auteurs : H. Harrington CLEVELAND, Auteur ; Gabriel L. SCHLOMER, Auteur ; David J. VANDENBERGH, Auteur ; Mark FEINBERG, Auteur ; Mark GREENBERG, Auteur ; Richard SPOTH, Auteur ; Cleve REDMOND, Auteur ; Mark D. SHRIVER, Auteur ; Arslan A. ZAIDI, Auteur ; Kerry L. HAIR, Auteur Article en page(s) : p.51-67 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4). Variation in this gene and maternal involvement were hypothesized to moderate the influence of intervention status on alcohol use. The PROSPER data used were drawn from 28 communities randomly assigned to intervention or comparison conditions. Participating youth were assessed in five in-home interviews from sixth to ninth grades. A main effect of sixth-grade pretest maternal involvement on ninth-grade alcohol use was found. Neither intervention status nor DRD4 variation was unconditionally linked to ninth-grade drinking. However, moderation analyses revealed a significant three-way interaction among DRD4 status, maternal involvement, and intervention condition. Follow-up analyses revealed that prevention reduced drinking risk, but only for youth with at least one DRD4 seven-repeat allele who reported average or greater pretest levels of maternal involvement. To determine if this conditional pattern was limited to the DRD4 gene, we repeated analyses using the serotonin transporter linked polymorphic region site near the serotonin transporter gene. The results for this supplemental analysis revealed a significant three-way interaction similar but not identical to that found for DRD4. En ligne : http://dx.doi.org/10.1017/S0954579414001291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants [Texte imprimé et/ou numérique] / H. Harrington CLEVELAND, Auteur ; Gabriel L. SCHLOMER, Auteur ; David J. VANDENBERGH, Auteur ; Mark FEINBERG, Auteur ; Mark GREENBERG, Auteur ; Richard SPOTH, Auteur ; Cleve REDMOND, Auteur ; Mark D. SHRIVER, Auteur ; Arslan A. ZAIDI, Auteur ; Kerry L. HAIR, Auteur . - p.51-67. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.51-67 Index. décimale : PER Périodiques Résumé : Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4). Variation in this gene and maternal involvement were hypothesized to moderate the influence of intervention status on alcohol use. The PROSPER data used were drawn from 28 communities randomly assigned to intervention or comparison conditions. Participating youth were assessed in five in-home interviews from sixth to ninth grades. A main effect of sixth-grade pretest maternal involvement on ninth-grade alcohol use was found. Neither intervention status nor DRD4 variation was unconditionally linked to ninth-grade drinking. However, moderation analyses revealed a significant three-way interaction among DRD4 status, maternal involvement, and intervention condition. Follow-up analyses revealed that prevention reduced drinking risk, but only for youth with at least one DRD4 seven-repeat allele who reported average or greater pretest levels of maternal involvement. To determine if this conditional pattern was limited to the DRD4 gene, we repeated analyses using the serotonin transporter linked polymorphic region site near the serotonin transporter gene. The results for this supplemental analysis revealed a significant three-way interaction similar but not identical to that found for DRD4. En ligne : http://dx.doi.org/10.1017/S0954579414001291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

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