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Détail de l'auteur
Auteur Ajay S. PILLAI |
Documents disponibles écrits par cet auteur (2)
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Altered task?related modulation of long?range connectivity in children with autism / Ajay S. PILLAI in Autism Research, 11-2 (February 2018)
[article]
Titre : Altered task?related modulation of long?range connectivity in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur Année de publication : 2018 Article en page(s) : p.245-257 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-2 (February 2018) . - p.245-257[article] Altered task?related modulation of long?range connectivity in children with autism [Texte imprimé et/ou numérique] / Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur . - 2018 . - p.245-257.
Langues : Anglais (eng)
in Autism Research > 11-2 (February 2018) . - p.245-257
Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 Dyspraxia in ASD: Impaired coordination of movement elements / Danielle MCAULIFFE in Autism Research, 10-4 (April 2017)
[article]
Titre : Dyspraxia in ASD: Impaired coordination of movement elements Type de document : Texte imprimé et/ou numérique Auteurs : Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.648-652 Langues : Anglais (eng) Mots-clés : dyspraxia autism motor planning divided attention multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P?0.001). Whereas both groups had greater difficulty performing simultaneous than serial gestures, children with ASD had a 2.6-times greater performance decrement with simultaneous (vs. serial) gestures than controls. These results point to a potential deficit in the simultaneous processing of multiple inputs and outputs in ASD. Such deficits could relate to models of social interaction that highlight the parallel-processing nature of social communication. En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-4 (April 2017) . - p.648-652[article] Dyspraxia in ASD: Impaired coordination of movement elements [Texte imprimé et/ou numérique] / Danielle MCAULIFFE, Auteur ; Ajay S. PILLAI, Auteur ; Alyssa TIEDEMANN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Joshua B. EWEN, Auteur . - p.648-652.
Langues : Anglais (eng)
in Autism Research > 10-4 (April 2017) . - p.648-652
Mots-clés : dyspraxia autism motor planning divided attention multiple task interference Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) have long been known to have deficits in the performance of praxis gestures; these motor deficits also correlate with social and communicative deficits. To date, the precise nature of the errors involved in praxis has not been clearly mapped out. Based on observations of individuals with ASD performing gestures, we hypothesized that the simultaneous execution of multiple movement elements is especially impaired in affected children. We examined 25 school-aged participants with ASD and 25 age-matched controls performing seven simultaneous gestures that required the concurrent performance of movement elements and nine serial gestures, in which all elements were performed serially. There was indeed a group × gesture-type interaction (P?0.001). Whereas both groups had greater difficulty performing simultaneous than serial gestures, children with ASD had a 2.6-times greater performance decrement with simultaneous (vs. serial) gestures than controls. These results point to a potential deficit in the simultaneous processing of multiple inputs and outputs in ASD. Such deficits could relate to models of social interaction that highlight the parallel-processing nature of social communication. En ligne : http://dx.doi.org/10.1002/aur.1693 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307