Language and sociability: insights from Williams syndrome / I. FISHMAN in Journal of Neurodevelopmental Disorders, 3-3 (September 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.185-92 Titre : Language and sociability: insights from Williams syndrome Type de document : Texte imprimé et/ou numérique Auteurs : I. FISHMAN, Auteur ; A. YAM, Auteur ; Ursula BELLUGI, Auteur ; D. MILLS, Auteur Article en page(s) : p.185-92 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One of the most compelling features of Williams syndrome (WS) is the widely reported excessive sociability, accompanied by a relative proficiency in expressive language, which stands in stark contrast with significant intellectual and nonverbal impairments. It has been proposed that the unique language skills observed in WS are implicated in the strong drive to interact and communicate with others, which has been widely documented in WS. Nevertheless, this proposition has yet to be empirically examined. The present study aimed at investigating the relationship between a brain index of language processing and judgments of approachability of faces, as a proxy for sociability, in individuals with WS as contrasted to typical controls. Results revealed a significant and substantial association between the two in the WS, but not in the control group, supporting the hitherto untested notion that language use in WS might be uniquely related to their excessive social drive. En ligne : http://dx.doi.org/10.1007/s11689-011-9086-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Language and sociability: insights from Williams syndrome [Texte imprimé et/ou numérique] / I. FISHMAN, Auteur ; A. YAM, Auteur ; Ursula BELLUGI, Auteur ; D. MILLS, Auteur . - p.185-92. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.185-92 Index. décimale : PER Périodiques Résumé : One of the most compelling features of Williams syndrome (WS) is the widely reported excessive sociability, accompanied by a relative proficiency in expressive language, which stands in stark contrast with significant intellectual and nonverbal impairments. It has been proposed that the unique language skills observed in WS are implicated in the strong drive to interact and communicate with others, which has been widely documented in WS. Nevertheless, this proposition has yet to be empirically examined. The present study aimed at investigating the relationship between a brain index of language processing and judgments of approachability of faces, as a proxy for sociability, in individuals with WS as contrasted to typical controls. Results revealed a significant and substantial association between the two in the WS, but not in the control group, supporting the hitherto untested notion that language use in WS might be uniquely related to their excessive social drive. En ligne : http://dx.doi.org/10.1007/s11689-011-9086-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome / M. MIMURA in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98 Titre : A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : M. MIMURA, Auteur ; F. HOEFT, Auteur ; M. KATO, Auteur ; N. KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; D. MILLS, Auteur ; A. GALABURDA, Auteur ; J. R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; A. L. REISS, Auteur Article en page(s) : p.93-98 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome [Texte imprimé et/ou numérique] / M. MIMURA, Auteur ; F. HOEFT, Auteur ; M. KATO, Auteur ; N. KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; D. MILLS, Auteur ; A. GALABURDA, Auteur ; J. R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; A. L. REISS, Auteur . - p.93-98. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98 Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

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