Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system / H. KUMAZAKI in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 6p. Titre : Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur Article en page(s) : 6p. Langues : Anglais (eng) Mots-clés : Adolescent  Aerosols  Autism Spectrum Disorder/physiopathology/psychology  Caproates  Case-Control Studies  Child  Diagnostic Equipment  Equipment Design  Female  Humans  Hypesthesia/etiology/physiopathology/psychology  Male  Odorants  Olfactory Perception/physiology  Pentanols  Pulsatile Flow  Sensory Thresholds/physiology  Autism spectrum disorder  Laboratory-based studies  Olfaction  Olfactory detection threshold  Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur . - 6p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 6p. Mots-clés : Adolescent  Aerosols  Autism Spectrum Disorder/physiopathology/psychology  Caproates  Case-Control Studies  Child  Diagnostic Equipment  Equipment Design  Female  Humans  Hypesthesia/etiology/physiopathology/psychology  Male  Odorants  Olfactory Perception/physiology  Pentanols  Pulsatile Flow  Sensory Thresholds/physiology  Autism spectrum disorder  Laboratory-based studies  Olfaction  Olfactory detection threshold  Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Brief Report: Evaluating the Utility of Varied Technological Agents to Elicit Social Attention from Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1700-1708 Titre : Brief Report: Evaluating the Utility of Varied Technological Agents to Elicit Social Attention from Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; Zachary WARREN, Auteur ; A. SWANSON, Auteur ; Y. YOSHIKAWA, Auteur ; Y. MATSUMOTO, Auteur ; Y. YOSHIMURA, Auteur ; J. SHIMAYA, Auteur ; H. ISHIGURO, Auteur ; N. SARKAR, Auteur ; J. WADE, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur ; M. KIKUCHI, Auteur Article en page(s) : p.1700-1708 Langues : Anglais (eng) Mots-clés : Android robot  Autism spectrum disorders  Digital avatar  Robot  Technological agents Index. décimale : PER Périodiques Résumé : Technological agents could be effective tools to be used in interventions for enhancing social orienting for some young children with ASD. We examined response to social bids in preschool children with ASD and typical development (TD) at a very early age (i.e., around 3 years) using social prompts presented by technological agents of various forms and human comparisons. Children with ASD demonstrated less response overall to social bids compared to TD controls, across agents or human. They responded more often to a simple humanoid robot and the simple avatar compared to the human. These results support the potential utilization of specific robotic and technological agents for harnessing and potentially increasing motivation to socially-relevant behaviors in some young children with ASD. En ligne : https://dx.doi.org/10.1007/s10803-018-3841-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Brief Report: Evaluating the Utility of Varied Technological Agents to Elicit Social Attention from Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; Zachary WARREN, Auteur ; A. SWANSON, Auteur ; Y. YOSHIKAWA, Auteur ; Y. MATSUMOTO, Auteur ; Y. YOSHIMURA, Auteur ; J. SHIMAYA, Auteur ; H. ISHIGURO, Auteur ; N. SARKAR, Auteur ; J. WADE, Auteur ; M. MIMURA, Auteur ; Y. MINABE, Auteur ; M. KIKUCHI, Auteur . - p.1700-1708. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1700-1708 Mots-clés : Android robot  Autism spectrum disorders  Digital avatar  Robot  Technological agents Index. décimale : PER Périodiques Résumé : Technological agents could be effective tools to be used in interventions for enhancing social orienting for some young children with ASD. We examined response to social bids in preschool children with ASD and typical development (TD) at a very early age (i.e., around 3 years) using social prompts presented by technological agents of various forms and human comparisons. Children with ASD demonstrated less response overall to social bids compared to TD controls, across agents or human. They responded more often to a simple humanoid robot and the simple avatar compared to the human. These results support the potential utilization of specific robotic and technological agents for harnessing and potentially increasing motivation to socially-relevant behaviors in some young children with ASD. En ligne : https://dx.doi.org/10.1007/s10803-018-3841-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1709-1716 Titre : Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; Y. YOSHIKAWA, Auteur ; Y. YOSHIMURA, Auteur ; T. IKEDA, Auteur ; C. HASEGAWA, Auteur ; Daisuke N. SAITO, Auteur ; J. SHIMAYA, Auteur ; H. ISHIGURO, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur Article en page(s) : p.1709-1716 Langues : Anglais (eng) Mots-clés : Ados  Autism spectrum disorders  Robot  Severity  Social communication  Typical development Index. décimale : PER Périodiques Résumé : We investigated the feasibility of our novel evaluation system for use with children with autism spectrum disorders (ASD). We prepared the experimental setting with two humanoid robots in reference to the birthday party scene in the Autism Diagnostic Observational Schedule (ADOS). We assessed the relationship between social communication ability measured in the ADOS condition (i.e., with a human clinician) and in a robotic condition for children with ASD. There were significant correlations between the social communication scores in the gold-standard ADOS condition and the robotic condition for children with ASD. The current work provides support for a unique application of a robotic system (i.e., two robot-mediated interaction) to evaluate the severity of autistic traits for children with ASD. En ligne : https://dx.doi.org/10.1007/s10803-018-3848-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; Y. YOSHIKAWA, Auteur ; Y. YOSHIMURA, Auteur ; T. IKEDA, Auteur ; C. HASEGAWA, Auteur ; Daisuke N. SAITO, Auteur ; J. SHIMAYA, Auteur ; H. ISHIGURO, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur . - p.1709-1716. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1709-1716 Mots-clés : Ados  Autism spectrum disorders  Robot  Severity  Social communication  Typical development Index. décimale : PER Périodiques Résumé : We investigated the feasibility of our novel evaluation system for use with children with autism spectrum disorders (ASD). We prepared the experimental setting with two humanoid robots in reference to the birthday party scene in the Autism Diagnostic Observational Schedule (ADOS). We assessed the relationship between social communication ability measured in the ADOS condition (i.e., with a human clinician) and in a robotic condition for children with ASD. There were significant correlations between the social communication scores in the gold-standard ADOS condition and the robotic condition for children with ASD. The current work provides support for a unique application of a robotic system (i.e., two robot-mediated interaction) to evaluate the severity of autistic traits for children with ASD. En ligne : https://dx.doi.org/10.1007/s10803-018-3848-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 49-8 (August 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3462-3469 Titre : Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur Article en page(s) : p.3462-3469 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Olfactory adaptation  Pulse ejection system  Social impairment  Typical development Index. décimale : PER Périodiques Résumé : Olfactory adaptation is an important process that allows the individual to adjust to changes in the environment. This process has been proposed to be aberrant in individuals with autism spectrum disorders (ASD). However, few studies have examined olfactory adaptation in children with ASD. We examined olfactory adaptation in children with ASD and typically developing (TD) children using a pulse ejection system, which resolved problems associated with previous laboratory-based olfactory psychophysical studies. Nine children with ASD and nine TD children participated in this study and all participants completed the entire experiment. Using this system, we found that the TD group showed greater adaptation than the ASD group. Our results provide a better understanding of olfactory adaptation in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04053-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Brief Report: Olfactory Adaptation in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; M. MIYAO, Auteur ; K. I. OKADA, Auteur ; M. MIMURA, Auteur ; M. KIKUCHI, Auteur . - p.3462-3469. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3462-3469 Mots-clés : Autism spectrum disorders  Olfactory adaptation  Pulse ejection system  Social impairment  Typical development Index. décimale : PER Périodiques Résumé : Olfactory adaptation is an important process that allows the individual to adjust to changes in the environment. This process has been proposed to be aberrant in individuals with autism spectrum disorders (ASD). However, few studies have examined olfactory adaptation in children with ASD. We examined olfactory adaptation in children with ASD and typically developing (TD) children using a pulse ejection system, which resolved problems associated with previous laboratory-based olfactory psychophysical studies. Nine children with ASD and nine TD children participated in this study and all participants completed the entire experiment. Using this system, we found that the TD group showed greater adaptation than the ASD group. Our results provide a better understanding of olfactory adaptation in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04053-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review / F. MASUDA in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1614-1629 Titre : Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : F. MASUDA, Auteur ; S. NAKAJIMA, Auteur ; T. MIYAZAKI, Auteur ; R. TARUMI, Auteur ; K. OGYU, Auteur ; M. WADA, Auteur ; S. TSUGAWA, Auteur ; P. E. CROARKIN, Auteur ; M. MIMURA, Auteur ; Y. NODA, Auteur Article en page(s) : p.1614-1629 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review [Texte imprimé et/ou numérique] / F. MASUDA, Auteur ; S. NAKAJIMA, Auteur ; T. MIYAZAKI, Auteur ; R. TARUMI, Auteur ; K. OGYU, Auteur ; M. WADA, Auteur ; S. TSUGAWA, Auteur ; P. E. CROARKIN, Auteur ; M. MIMURA, Auteur ; Y. NODA, Auteur . - p.1614-1629. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1614-1629 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders / S. KUROKAWA in Autism Research, 14-9 (September 2021)  

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Job interview training targeting nonverbal communication using an android robot for individuals with autism spectrum disorder / H. KUMAZAKI in Autism, 23-6 (August 2019)  

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A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome / M. MIMURA in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)  

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Relationship Between Odor Identification and Visual Distractors in Children with Autism Spectrum Disorders / H. KUMAZAKI in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

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