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Détail de l'auteur
Auteur F. HOEFT |
Documents disponibles écrits par cet auteur (2)



A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome / M. MIMURA in Journal of Neurodevelopmental Disorders, 2-2 (June 2010)
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Titre : A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : M. MIMURA, Auteur ; F. HOEFT, Auteur ; M. KATO, Auteur ; N. KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; D. MILLS, Auteur ; A. GALABURDA, Auteur ; J. R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; A. L. REISS, Auteur Article en page(s) : p.93-98 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342
in Journal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98[article] A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome [Texte imprimé et/ou numérique] / M. MIMURA, Auteur ; F. HOEFT, Auteur ; M. KATO, Auteur ; N. KOBAYASHI, Auteur ; K. SHEAU, Auteur ; J. PIGGOT, Auteur ; D. MILLS, Auteur ; A. GALABURDA, Auteur ; J. R. KORENBERG, Auteur ; Ursula BELLUGI, Auteur ; A. L. REISS, Auteur . - p.93-98.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 2-2 (June 2010) . - p.93-98
Index. décimale : PER Périodiques Résumé : Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. METHODS: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS. En ligne : http://dx.doi.org/10.1007/s11689-009-9041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 The neural basis of auditory temporal discrimination in girls with fragile X syndrome / S. S. HALL in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)
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Titre : The neural basis of auditory temporal discrimination in girls with fragile X syndrome Type de document : Texte imprimé et/ou numérique Auteurs : S. S. HALL, Auteur ; E. WALTER, Auteur ; E. SHERMAN, Auteur ; F. HOEFT, Auteur ; A. L. REISS, Auteur Article en page(s) : p.91-9 Langues : Anglais (eng) Mots-clés : Discrimination Fragile X syndrome Temporal processing fMRI Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a common genetic disorder in which temporal processing may be impaired. To our knowledge however, no studies have examined the neural basis of temporal discrimination in individuals with FXS using functional magnetic resonance imaging (fMRI). Ten girls with fragile X syndrome and ten developmental age-matched typically developing controls performed an auditory temporal discrimination task in a 3T scanner. Girls with FXS showed significantly greater brain activation in a left-lateralized network, comprising left medial frontal gyrus, left superior and middle temporal gyrus, left cerebellum, and left brainstem (pons), when compared to a developmental age-matched typically developing group of subjects who had similar in-scanner task performance. There were no regions that showed significantly greater brain activation in the control group compared to individuals with FXS. These data indicate that networks of brain regions involved in auditory temporal processing may be dysfunctional in FXS. In particular, it is possible that girls with FXS employ left hemispheric resources to overcompensate for relative right hemispheric dysfunction. En ligne : http://dx.doi.org/10.1007/s11689-009-9007-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341
in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.91-9[article] The neural basis of auditory temporal discrimination in girls with fragile X syndrome [Texte imprimé et/ou numérique] / S. S. HALL, Auteur ; E. WALTER, Auteur ; E. SHERMAN, Auteur ; F. HOEFT, Auteur ; A. L. REISS, Auteur . - p.91-9.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.91-9
Mots-clés : Discrimination Fragile X syndrome Temporal processing fMRI Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a common genetic disorder in which temporal processing may be impaired. To our knowledge however, no studies have examined the neural basis of temporal discrimination in individuals with FXS using functional magnetic resonance imaging (fMRI). Ten girls with fragile X syndrome and ten developmental age-matched typically developing controls performed an auditory temporal discrimination task in a 3T scanner. Girls with FXS showed significantly greater brain activation in a left-lateralized network, comprising left medial frontal gyrus, left superior and middle temporal gyrus, left cerebellum, and left brainstem (pons), when compared to a developmental age-matched typically developing group of subjects who had similar in-scanner task performance. There were no regions that showed significantly greater brain activation in the control group compared to individuals with FXS. These data indicate that networks of brain regions involved in auditory temporal processing may be dysfunctional in FXS. In particular, it is possible that girls with FXS employ left hemispheric resources to overcompensate for relative right hemispheric dysfunction. En ligne : http://dx.doi.org/10.1007/s11689-009-9007-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341