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Détail de l'auteur
Auteur K. R. LAURENS |
Documents disponibles écrits par cet auteur (2)
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Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness / M. J. GREEN in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)
[article]
Titre : Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness Type de document : Texte imprimé et/ou numérique Auteurs : M. J. GREEN, Auteur ; M. KARIUKI, Auteur ; K. DEAN, Auteur ; K. R. LAURENS, Auteur ; S. TZOUMAKIS, Auteur ; F. HARRIS, Auteur ; Vaughan J. CARR, Auteur Article en page(s) : p.801-810 Langues : Anglais (eng) Mots-clés : Cns Risk factors developmental epidemiology developmental psychopathology infection maternal factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness. Here, we investigated the effects of in utero exposure to maternal infection and noninfectious diseases during pregnancy on offspring developmental vulnerabilities at age 5 years, in the context of estimated effects for early childhood exposures to infectious and noninfectious diseases and maternal mental illness. METHODS: We used population data for 66,045 children from an intergenerational record linkage study (the New South Wales Child Development Study), for whom a cross-sectional assessment of five developmental competencies (physical, social, emotional, cognitive, and communication) was obtained at school entry, using the Australian Early Development Census (AEDC). Child and maternal exposures to infectious or noninfectious diseases were determined from the NSW Ministry of Health Admitted Patients Data Collection (APDC) and maternal mental illness exposure was derived from both APDC and Mental Health Ambulatory Data collections. Multinomial logistic regression analyses were used to examine unadjusted and adjusted associations between these physical and mental health exposures and child developmental vulnerabilities at age 5 years. RESULTS: Among the physical disease exposures, maternal infectious diseases during pregnancy and early childhood infection conferred the largest associations with developmental vulnerabilities at age 5 years; maternal noninfectious illness during pregnancy also retained small but significant associations with developmental vulnerabilities even when adjusted for other physical and mental illness exposures and covariates known to be associated with early childhood development (e.g., child's sex, socioeconomic disadvantage, young maternal age, prenatal smoking). Among all exposures examined, maternal mental illness first diagnosed prior to childbirth conferred the greatest odds of developmental vulnerability at age 5 years. CONCLUSIONS: Prenatal exposure to infectious or noninfectious diseases appear to influence early childhood physical, social, emotional and cognitive developmental vulnerabilities that may represent intermediate phenotypes for subsequent mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12856 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.801-810[article] Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness [Texte imprimé et/ou numérique] / M. J. GREEN, Auteur ; M. KARIUKI, Auteur ; K. DEAN, Auteur ; K. R. LAURENS, Auteur ; S. TZOUMAKIS, Auteur ; F. HARRIS, Auteur ; Vaughan J. CARR, Auteur . - p.801-810.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.801-810
Mots-clés : Cns Risk factors developmental epidemiology developmental psychopathology infection maternal factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness. Here, we investigated the effects of in utero exposure to maternal infection and noninfectious diseases during pregnancy on offspring developmental vulnerabilities at age 5 years, in the context of estimated effects for early childhood exposures to infectious and noninfectious diseases and maternal mental illness. METHODS: We used population data for 66,045 children from an intergenerational record linkage study (the New South Wales Child Development Study), for whom a cross-sectional assessment of five developmental competencies (physical, social, emotional, cognitive, and communication) was obtained at school entry, using the Australian Early Development Census (AEDC). Child and maternal exposures to infectious or noninfectious diseases were determined from the NSW Ministry of Health Admitted Patients Data Collection (APDC) and maternal mental illness exposure was derived from both APDC and Mental Health Ambulatory Data collections. Multinomial logistic regression analyses were used to examine unadjusted and adjusted associations between these physical and mental health exposures and child developmental vulnerabilities at age 5 years. RESULTS: Among the physical disease exposures, maternal infectious diseases during pregnancy and early childhood infection conferred the largest associations with developmental vulnerabilities at age 5 years; maternal noninfectious illness during pregnancy also retained small but significant associations with developmental vulnerabilities even when adjusted for other physical and mental illness exposures and covariates known to be associated with early childhood development (e.g., child's sex, socioeconomic disadvantage, young maternal age, prenatal smoking). Among all exposures examined, maternal mental illness first diagnosed prior to childbirth conferred the greatest odds of developmental vulnerability at age 5 years. CONCLUSIONS: Prenatal exposure to infectious or noninfectious diseases appear to influence early childhood physical, social, emotional and cognitive developmental vulnerabilities that may represent intermediate phenotypes for subsequent mental disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12856 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia / H. DICKSON in Journal of Child Psychology and Psychiatry, 59-11 (November 2018)
[article]
Titre : Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : H. DICKSON, Auteur ; A. E. CULLEN, Auteur ; R. JONES, Auteur ; A. REICHENBERG, Auteur ; R. E. ROBERTS, Auteur ; S. HODGINS, Auteur ; R. G. MORRIS, Auteur ; K. R. LAURENS, Auteur Article en page(s) : p.1215-1224 Langues : Anglais (eng) Mots-clés : Psychosis academic performance executive function intelligence memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Among adults with schizophrenia, evidence suggests that premorbid deficits in different cognitive domains follow distinct developmental courses during childhood and adolescence. The aim of this study was to delineate trajectories of adolescent cognitive functions prospectively among different groups of youth at-risk for schizophrenia, relative to their typically developing (TD) peers. METHOD: Using linear mixed models adjusted for sex, ethnicity, parental occupation and practice effects, cognitive development between ages 9 and 16 years was compared for youth characterised by a triad of well-replicated developmental antecedents of schizophrenia (ASz; N = 32) and youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 29), relative to TD youth (N = 45). Participants completed measures of IQ, scholastic achievement, memory and executive function at three time-points, separated by approximately 24-month intervals. RESULTS: Compared to TD youth, both ASz and FHx youth displayed stable developmental deficits in verbal working memory and inhibition/switching executive functions. ASz youth additionally presented with stable deficits in measures of vocabulary (IQ), word reading, numerical operations, and category fluency executive function, and a slower rate of growth (developmental lag) on spelling from 9 to 16 years than TD peers. Conversely, faster rates of growth relative to TD peers (developmental delay) were observed on visual and verbal memory, and on category fluency executive function (ASz youth only) and on matrix reasoning (IQ) and word reading (FHx youth only). CONCLUSIONS: These differential patterns of deviation from normative adolescent cognitive development among at-risk youth imply potential for cognitive rehabilitation targeting of specific cognitive deficits at different developmental phases. En ligne : http://dx.doi.org/10.1111/jcpp.12912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370
in Journal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1215-1224[article] Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia [Texte imprimé et/ou numérique] / H. DICKSON, Auteur ; A. E. CULLEN, Auteur ; R. JONES, Auteur ; A. REICHENBERG, Auteur ; R. E. ROBERTS, Auteur ; S. HODGINS, Auteur ; R. G. MORRIS, Auteur ; K. R. LAURENS, Auteur . - p.1215-1224.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1215-1224
Mots-clés : Psychosis academic performance executive function intelligence memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Among adults with schizophrenia, evidence suggests that premorbid deficits in different cognitive domains follow distinct developmental courses during childhood and adolescence. The aim of this study was to delineate trajectories of adolescent cognitive functions prospectively among different groups of youth at-risk for schizophrenia, relative to their typically developing (TD) peers. METHOD: Using linear mixed models adjusted for sex, ethnicity, parental occupation and practice effects, cognitive development between ages 9 and 16 years was compared for youth characterised by a triad of well-replicated developmental antecedents of schizophrenia (ASz; N = 32) and youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 29), relative to TD youth (N = 45). Participants completed measures of IQ, scholastic achievement, memory and executive function at three time-points, separated by approximately 24-month intervals. RESULTS: Compared to TD youth, both ASz and FHx youth displayed stable developmental deficits in verbal working memory and inhibition/switching executive functions. ASz youth additionally presented with stable deficits in measures of vocabulary (IQ), word reading, numerical operations, and category fluency executive function, and a slower rate of growth (developmental lag) on spelling from 9 to 16 years than TD peers. Conversely, faster rates of growth relative to TD peers (developmental delay) were observed on visual and verbal memory, and on category fluency executive function (ASz youth only) and on matrix reasoning (IQ) and word reading (FHx youth only). CONCLUSIONS: These differential patterns of deviation from normative adolescent cognitive development among at-risk youth imply potential for cognitive rehabilitation targeting of specific cognitive deficits at different developmental phases. En ligne : http://dx.doi.org/10.1111/jcpp.12912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370