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Auteur Elana SCHETTINI |
Documents disponibles écrits par cet auteur (1)
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Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study / Elana SCHETTINI in Development and Psychopathology, 33-5 (December 2021)
[article]
Titre : Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study Type de document : Texte imprimé et/ou numérique Auteurs : Elana SCHETTINI, Auteur ; Sylia WILSON, Auteur ; Theodore P. BEAUCHAINE, Auteur Article en page(s) : p.1620-1633 Langues : Anglais (eng) Mots-clés : amygdala anterior cingulate RDoC heterotypic comorbidity striatum Index. décimale : PER Périodiques Résumé : Despite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing–externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study (N = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex. En ligne : http://dx.doi.org/10.1017/S0954579421000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Development and Psychopathology > 33-5 (December 2021) . - p.1620-1633[article] Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study [Texte imprimé et/ou numérique] / Elana SCHETTINI, Auteur ; Sylia WILSON, Auteur ; Theodore P. BEAUCHAINE, Auteur . - p.1620-1633.
Langues : Anglais (eng)
in Development and Psychopathology > 33-5 (December 2021) . - p.1620-1633
Mots-clés : amygdala anterior cingulate RDoC heterotypic comorbidity striatum Index. décimale : PER Périodiques Résumé : Despite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing–externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study (N = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex. En ligne : http://dx.doi.org/10.1017/S0954579421000560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457