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Auteur Nadia COSCINI |
Documents disponibles écrits par cet auteur (1)
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Association between early androgens and autistic traits: A systematic review and meta-analysis / Nadia COSCINI in Research in Autism Spectrum Disorders, 85 (July 2021)
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Titre : Association between early androgens and autistic traits: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Nadia COSCINI, Auteur ; Katrina WILLIAMS, Auteur ; Denise CHEW, Auteur ; Kenneth C. PANG, Auteur ; Michele A. O’CONNELL, Auteur ; Tamara MAY, Auteur Article en page(s) : 101789 Langues : Anglais (eng) Mots-clés : Autism Androgen Testosterone Extreme male brain Systematic review Index. décimale : PER Périodiques Résumé : Background We systematically reviewed evidence for the androgen theory which proposes exposure to elevated levels of androgens in early development predisposes to autistic behaviour. Method MEDLINE, EMBASE and Pubmed were searched for studies measuring androgens in mother or child during pregnancy or the first year of life and examined autistic behaviours (including social ability and repetitive behaviour) and language measured up to age 24 years. Results Twenty-five of 3,041 publications met inclusion criteria, exploring 11 unique cohorts. Overall quality of evidence was very low as studies were non-experimental and most had high risk of bias. Only one research group found significant associations between autistic behaviour and androgens in amniotic fluid. There were mixed findings across the studies reviewed. Meta-analysis indicated a small significant pooled association between autistic behaviour and androgens in amniotic fluid (males and females combined; 3 studies), 0.28 [95 % CI 0.14, 0.41], also significant in males and females separately. Conclusions Despite interest in this topic, of studies exploring direct measures of early androgens and later autistic traits, there is only a small amount of low-quality evidence from independent cohorts. The androgen theory of autism is neither confirmed nor refuted by the existing association studies included in this review. En ligne : https://doi.org/10.1016/j.rasd.2021.101789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101789[article] Association between early androgens and autistic traits: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Nadia COSCINI, Auteur ; Katrina WILLIAMS, Auteur ; Denise CHEW, Auteur ; Kenneth C. PANG, Auteur ; Michele A. O’CONNELL, Auteur ; Tamara MAY, Auteur . - 101789.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101789
Mots-clés : Autism Androgen Testosterone Extreme male brain Systematic review Index. décimale : PER Périodiques Résumé : Background We systematically reviewed evidence for the androgen theory which proposes exposure to elevated levels of androgens in early development predisposes to autistic behaviour. Method MEDLINE, EMBASE and Pubmed were searched for studies measuring androgens in mother or child during pregnancy or the first year of life and examined autistic behaviours (including social ability and repetitive behaviour) and language measured up to age 24 years. Results Twenty-five of 3,041 publications met inclusion criteria, exploring 11 unique cohorts. Overall quality of evidence was very low as studies were non-experimental and most had high risk of bias. Only one research group found significant associations between autistic behaviour and androgens in amniotic fluid. There were mixed findings across the studies reviewed. Meta-analysis indicated a small significant pooled association between autistic behaviour and androgens in amniotic fluid (males and females combined; 3 studies), 0.28 [95 % CI 0.14, 0.41], also significant in males and females separately. Conclusions Despite interest in this topic, of studies exploring direct measures of early androgens and later autistic traits, there is only a small amount of low-quality evidence from independent cohorts. The androgen theory of autism is neither confirmed nor refuted by the existing association studies included in this review. En ligne : https://doi.org/10.1016/j.rasd.2021.101789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458